Approaching anion solvation from the bottom up: infrared studies of negatively charged complexes and clusters. We will employ novel spectroscopic strategies to probe the structures of mass-selected anion complexes and clusters in the gas-phase with the purpose of exploring non-covalent forces responsible for anion solvation. The work is motivated by a recognition that anions serve as key participants in a host of natural and industrial chemical processes, and that their physical and chemical pro ....Approaching anion solvation from the bottom up: infrared studies of negatively charged complexes and clusters. We will employ novel spectroscopic strategies to probe the structures of mass-selected anion complexes and clusters in the gas-phase with the purpose of exploring non-covalent forces responsible for anion solvation. The work is motivated by a recognition that anions serve as key participants in a host of natural and industrial chemical processes, and that their physical and chemical properties depend critically upon interactions with solvent molecules. The experimental results should serve as a critical test for computational approaches to describing anion-neutral interactions, and provide new insights into the behaviour of electrolytes, acid-base chemistry, and fundamental bimolecular reactions.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775481
Funder
Australian Research Council
Funding Amount
$304,000.00
Summary
X-ray Molecular Structure Elucidation Facility (MSEF). X-ray diffraction plays a key role in identification and molecular characterization. X-ray techniques are the single most widely used analytical resource in structure determination and provide invaluable information for scientists working in the fields of synthesis, nanotechnology, polymer chemistry, and protein chemistry amongst many others. The facility brings together a multidisciplinary team of scientists and provides state-of-the-art re ....X-ray Molecular Structure Elucidation Facility (MSEF). X-ray diffraction plays a key role in identification and molecular characterization. X-ray techniques are the single most widely used analytical resource in structure determination and provide invaluable information for scientists working in the fields of synthesis, nanotechnology, polymer chemistry, and protein chemistry amongst many others. The facility brings together a multidisciplinary team of scientists and provides state-of-the-art research and training facilities.Read moreRead less
Polyaniline Nanofibre Systems. Advanced materials such as the conducting polymer and applications of these materials at the nanoscale and up is clearly a cutting edge area of international interest. Development of readily processable nano systems has been a challenge with a clear scientific and commercial benefit. This proposal will bring linkages to Australia with the world leader in the field, Professor Kaner -UCLA, on the synthesis of polyaniline nanofibres and associated photowelding process ....Polyaniline Nanofibre Systems. Advanced materials such as the conducting polymer and applications of these materials at the nanoscale and up is clearly a cutting edge area of international interest. Development of readily processable nano systems has been a challenge with a clear scientific and commercial benefit. This proposal will bring linkages to Australia with the world leader in the field, Professor Kaner -UCLA, on the synthesis of polyaniline nanofibres and associated photowelding processes. The opportunities to Australia and the USA will be to expand the potential utility of such systems, which without such interactions would permit others to take a stake hold in this emergent and potentially lucrative technology.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0237664
Funder
Australian Research Council
Funding Amount
$900,000.00
Summary
High Resolution Mass Spectrometer for (MS)n Chemical Characterisation. A Fourier transform ion cyclotron resonance ("FT-ICR") mass spectrometer equipped with electrospray ionisation (ESI) plus a "benchtop" matrix assisted laser desorption ionisation time of flight (MALDI-TOF) mass spectrometer are required to support the research of ca 28 research groups, including 44 postdoctoral fellows, and 138 honours and postgraduate students. By means of its high resolution and (MS)n capabilities, the FT- ....High Resolution Mass Spectrometer for (MS)n Chemical Characterisation. A Fourier transform ion cyclotron resonance ("FT-ICR") mass spectrometer equipped with electrospray ionisation (ESI) plus a "benchtop" matrix assisted laser desorption ionisation time of flight (MALDI-TOF) mass spectrometer are required to support the research of ca 28 research groups, including 44 postdoctoral fellows, and 138 honours and postgraduate students. By means of its high resolution and (MS)n capabilities, the FT-ICR-MS will provide key structural information on a wide range of synthetic and natural chemical substances, including sequence (e.g. peptides) and fragmentation patterns, while the MALDI-TOF instrument will be used primarily for high through-put proteomic analyses.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989336
Funder
Australian Research Council
Funding Amount
$560,000.00
Summary
The South Australian Facility for Small and Large Molecule X-Ray Diffraction Structure Determination. The precise three dimensional arrangement of atoms within molecular and macromolecular structures defines their function. Thus, the discovery, development and application of biological compounds, catalysts, nanodevices and pharmaceuticals require X-ray diffraction structure determination. These endeavours underpin the conversion of academic research into real benefits for the community and are ....The South Australian Facility for Small and Large Molecule X-Ray Diffraction Structure Determination. The precise three dimensional arrangement of atoms within molecular and macromolecular structures defines their function. Thus, the discovery, development and application of biological compounds, catalysts, nanodevices and pharmaceuticals require X-ray diffraction structure determination. These endeavours underpin the conversion of academic research into real benefits for the community and are critical for the competitiveness of Australian industry, national productivity and economic growth. This application seeks to provide a facility for multidisciplinary scientific development that will enhance academic-industrial collaboration. This will position SA research community for scientific breakthroughs that benefit the Australian community.Read moreRead less
Reactivity and Spectroscopy of Gas Phase Metal Oxide Cluster Ions: Structure-Reactivity Correlations and Fundamental Insights into Heterogeneous Catalysis. This project will make use of world class ARC funded instrumentation to carry out breakthrough science. The research will contribute fundamental insights into chemical bond activation relevant to industrial catalytic processes important to national manufacturing industries. These insights will improve the efficiency and selectivity of catal ....Reactivity and Spectroscopy of Gas Phase Metal Oxide Cluster Ions: Structure-Reactivity Correlations and Fundamental Insights into Heterogeneous Catalysis. This project will make use of world class ARC funded instrumentation to carry out breakthrough science. The research will contribute fundamental insights into chemical bond activation relevant to industrial catalytic processes important to national manufacturing industries. These insights will improve the efficiency and selectivity of catalytic processes and lead to increased profitability and/or a reduction in unwanted side products and pollution. The project will train young scientists in important experimental and theoretical chemical techniques, and will enhance and contribute to Australia's international research profile.Read moreRead less
Structural determination of respiratory membrane protein complexes by X-ray crystallography. Membrane proteins form only 0.3% of the available protein structures in the protein data bank (PDB), yet 30% of the proteins in the human genome and 50% of human drug targets are membrane proteins. We have managed to increase the success rate through rational screening and development of new crystallization screens, with downstream implications for basic and medical research. Results from this proposal w ....Structural determination of respiratory membrane protein complexes by X-ray crystallography. Membrane proteins form only 0.3% of the available protein structures in the protein data bank (PDB), yet 30% of the proteins in the human genome and 50% of human drug targets are membrane proteins. We have managed to increase the success rate through rational screening and development of new crystallization screens, with downstream implications for basic and medical research. Results from this proposal will receive international recognition and will encourage more research in this field, attracting international funding, and create new research opportunities. Read moreRead less
Structures and Properties of beta-R3M (M = Si, Ge, Sn)- and beta-Chalcogenyl-substituted Carbenium Ions. The benefits of this work are many-fold. The scientific knowledge gained will be invaluable to all scientists working in organic chemistry; mechanistic chemists who will learn from the science, and synthetic organic chemists who can utilise the results when planning strategies for the synthesis of complex drugs. Another major benefit of this research is in the training of young scientists. Th ....Structures and Properties of beta-R3M (M = Si, Ge, Sn)- and beta-Chalcogenyl-substituted Carbenium Ions. The benefits of this work are many-fold. The scientific knowledge gained will be invaluable to all scientists working in organic chemistry; mechanistic chemists who will learn from the science, and synthetic organic chemists who can utilise the results when planning strategies for the synthesis of complex drugs. Another major benefit of this research is in the training of young scientists. The students who work on this proposal gain invaluable experience in many areas of chemistry, ranging from synthetic chemistry to structural chemistry and theoretical chemistry. They will also gain experience in important physical techniques from NMR spectroscopy to X-ray crystallography.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100131
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
Laser facility for ultra-sensitive molecular characterisation. Lasers are indispensable tools for the characterization and photochemical modification of molecular systems. Powerful lasers produce intense bursts of light across the electromagnetic spectrum, from the infrared to the ultraviolet. This versatility allows chemists to observe the dynamical behaviour of single molecules on ultra-fast timescales, to probe the shape of molecules relevant to the action of therapeutic drugs, to explore the ....Laser facility for ultra-sensitive molecular characterisation. Lasers are indispensable tools for the characterization and photochemical modification of molecular systems. Powerful lasers produce intense bursts of light across the electromagnetic spectrum, from the infrared to the ultraviolet. This versatility allows chemists to observe the dynamical behaviour of single molecules on ultra-fast timescales, to probe the shape of molecules relevant to the action of therapeutic drugs, to explore the characteristics of molecules found in space, and to initiate laser-activated chemical processes in microscopic dimensions to modify sensor surfaces. The proposed laser facility will enable progress in these areas and will help maintain Australia's research edge in nanotechnology and biotechnology.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453771
Funder
Australian Research Council
Funding Amount
$148,246.00
Summary
Electrochemical Electron Spin Resonance Spectrometer. Electron Spin Resonance Spectroscopy (ESR), is a technique used to determine the presence of free unpaired electrons in a sample. Detection and life time studies of radical species is critical to understanding the mechanisms involved in chemical reaction, sample degradation, performance upon exposure to light and oxidation or reduction processes. Combining ESR with an electrochemical interface permits in-situ studies on how electrons are inje ....Electrochemical Electron Spin Resonance Spectrometer. Electron Spin Resonance Spectroscopy (ESR), is a technique used to determine the presence of free unpaired electrons in a sample. Detection and life time studies of radical species is critical to understanding the mechanisms involved in chemical reaction, sample degradation, performance upon exposure to light and oxidation or reduction processes. Combining ESR with an electrochemical interface permits in-situ studies on how electrons are injected or removed from a sample, providing fundamental information on the processes occurring within the sample. Applications will be in the area of electrofunctional materials, complex biomolecular reactions, organic photovoltaics and new materials for nerve cell regeneration.Read moreRead less