Statistical Methods For Identifying Structural Variation In Tumour Genomes Using Next Generation Sequencing
Funder
National Health and Medical Research Council
Funding Amount
$243,458.00
Summary
New DNA sequencing technology can sequence a tumour genome affordably in 2 weeks. This re-sequencing data can be used to find small mutations and large-scale chromosomal rearrangements that together are the drivers of cancer. These may one day be used to guide cancer therapy. This project will develop new algorithms for finding mutations and apply these to discover the genetic basis of drug resistance in a model lymphoma system.
Stress-induced Genomic Instability As A Driver Of Adaptive Responses In Human Cancer Cells
Funder
National Health and Medical Research Council
Funding Amount
$690,426.00
Summary
Growing experimental evidence suggests human cancer cells use evolutionary conserved programs to regulate their mutation rates in response to pharmacological agents, accelerating adaptation and the emergence of resistance. The purpose of our study is to identify the common molecular pathways and genetic mechanisms driving the regulation of mutation rates. Targeting of these pathways using a new generation of “anti-evolution” drugs is an attractive possibility for novel therapeutic approaches.
Cerebral Palsy (CP) is a devastating, common developmental brain disorder once assumed to be due to lack of oxygen at birth. Using our unique Biobank with DNA and clinical data from families with a CP child, we are examining the genetic origins of CP and how genes and risk factors in pregnancy contribute. We will use computer modelling and testing in animals and brain cells, to understand causes of CP and devise predictive, preventative and therapeutic strategies.
How Do Cross-reactive Memory B Cells Affect Influenza Vaccine Titers?
Funder
National Health and Medical Research Council
Funding Amount
$798,049.00
Summary
Influenza vaccines are updated frequently to protect against the highly variable influenza virus. Despite careful selection of vaccine viruses, most influenza vaccines provide only modest protection and protection is poor some years. In turn, the response to vaccination varies between individuals. This probably reflects complex and variable histories of influenza infection and vaccination. The project investigates how past influenza exposure influences vaccine responses and effectiveness.
Assessing Infrastructure And Contextual Factors In Relation To Cardiometabolic Outcomes In Remote Indigenous Communities: Evidence For Policy Change
Funder
National Health and Medical Research Council
Funding Amount
$1,113,005.00
Summary
Cardiometabolic diseases account for the major burden of morbidity and mortality for Indigenous populations. This study with 75 remote Indigenous communities will be the first to evaluate features of their social, built and physical environments in relation to cardiometabolic risks and diseases. Policy-relevant results will identify features of environments to be targeted to reduce chronic diseases for Indigenous peoples in remote communities.
Design of Welded Steel Tubular Connections. Steel tubes are widely used in building, road transportation, defence, recreation, and agriculture industries. The proposed program will develop static design procedures for welded tubular connections to ensure safe and economic structures. The program will also investigate the behaviour of a popular tubular connection utilizing very high strength steel tubes to extend the existing design scope and enhance the utilization of Australian produced innovat ....Design of Welded Steel Tubular Connections. Steel tubes are widely used in building, road transportation, defence, recreation, and agriculture industries. The proposed program will develop static design procedures for welded tubular connections to ensure safe and economic structures. The program will also investigate the behaviour of a popular tubular connection utilizing very high strength steel tubes to extend the existing design scope and enhance the utilization of Australian produced innovative tubular sections. The notch toughness of steel tubes will also be investigated to avoid fracture failure of welded connections under dynamic loading. The program will build strong ongoing collaboration between University of Toronto and Monash University.Read moreRead less
Interaction of Local and Distortional Buckling in Thin-Walled High Strength Steel Sections. Recent research at the University of Sydney has shown that the local and distortional buckling modes in thin-walled high strength steel sections may have adverse interaction. Cold-Formed steel sections of this type are used in residential construction, ceiling systems, partitioning systems in offices and other light gauge applications. The project will develop mathematical models of the interaction beha ....Interaction of Local and Distortional Buckling in Thin-Walled High Strength Steel Sections. Recent research at the University of Sydney has shown that the local and distortional buckling modes in thin-walled high strength steel sections may have adverse interaction. Cold-Formed steel sections of this type are used in residential construction, ceiling systems, partitioning systems in offices and other light gauge applications. The project will develop mathematical models of the interaction behaviour of sections of this type for a wide range of section geometries. A major outcome will be design methods which accurately quantify the interaction behaviour based on the models. Testing will be undertaken to support the theoretical developments and to calibrate the design models.Read moreRead less
Defining Genetic And Epigenetic Variation During Early Development
Funder
National Health and Medical Research Council
Funding Amount
$996,075.00
Summary
We all began life with a set of genes inherited from our parents. However, it's now known that from the time we were in the womb onwards that genes can be turned off and on by the environment or even completely lost or gained. Even what your mother ate or how she behaved while she was pregnant could have influenced your future health. Because people are so different, we are studying the subtle differences between twins to tease out the factors that may influence our genes and our health.
Structural behaviour of innovative hollow flange steel members subject to local and lateral distortional buckling effects. This project will investigate the local and lateral distortional buckling behaviour of a new generation of innovative and cost-effective thin and high strength steel hollow flange sections (HFS) being developed using a unique dual weld and roll-forming technology. It will use experiments and advanced numerical modelling to develop fundamental behavioural and design data for ....Structural behaviour of innovative hollow flange steel members subject to local and lateral distortional buckling effects. This project will investigate the local and lateral distortional buckling behaviour of a new generation of innovative and cost-effective thin and high strength steel hollow flange sections (HFS) being developed using a unique dual weld and roll-forming technology. It will use experiments and advanced numerical modelling to develop fundamental behavioural and design data for HFS flexural members. Effects of web corrugations and punched holes will also be investigated. The research will enable innovative applications using HFS in the building industry in Australia and overseas. It will bring significant economic benefits to the industry partner, steel building industry, and Australia.Read moreRead less
Structural Behaviour of Innovative LiteSteel Beams, their Design Improvements and Applications. This project will develop a significant knowledge base, accurate design models and innovative application methods for the new LSB, which will be fully used by the collaborating partner in marketing them in Australia and overseas. Both construction and manufacturing industry sectors will benefit through the increased use of the innovative and lightweight hollow flange sections. Using the new sections a ....Structural Behaviour of Innovative LiteSteel Beams, their Design Improvements and Applications. This project will develop a significant knowledge base, accurate design models and innovative application methods for the new LSB, which will be fully used by the collaborating partner in marketing them in Australia and overseas. Both construction and manufacturing industry sectors will benefit through the increased use of the innovative and lightweight hollow flange sections. Using the new sections and the wealth of design information from this research, Australian engineers can develop cost-effective and safer building systems. Community at large, in particular rural and regional communities will gain through cheaper building systems, additional employment in LSB manufacturing and design, and opportunities locally and overseas.Read moreRead less