Role Of IGF Binding Protein-3 (IGFBP-3) And IGFBP-5 As Modulators Of Nuclear Hormone Signalling
Funder
National Health and Medical Research Council
Funding Amount
$465,750.00
Summary
The insulin-like growth factors are small proteins involved in the growth of most tissues. Their actions are regulated by binding to larger proteins (known as IGFBPs) in the bloodstream and outside the cell. However, some IGFBPs are also found inside cells, where they seem to carry out other functions. We believe that two of these binding proteins, IGFBP-3 and IGFBP-5, change the way cells respond to vitamin A and vitamin D. These two vitamins are important in cell growth and in the way certain ....The insulin-like growth factors are small proteins involved in the growth of most tissues. Their actions are regulated by binding to larger proteins (known as IGFBPs) in the bloodstream and outside the cell. However, some IGFBPs are also found inside cells, where they seem to carry out other functions. We believe that two of these binding proteins, IGFBP-3 and IGFBP-5, change the way cells respond to vitamin A and vitamin D. These two vitamins are important in cell growth and in the way certain cells perform specialised functions. In test-tube experiments, IGFBP-3 and IGFBP-5 interact directly with the receptors that regulate the effects of these hormones. If the same thing happens inside the cell, IGFBP-3 and IGFBP-5 could change the way these receptors respond to signals from outside the cell. We will investigate what effect these IGFBPs have in living cells and in whole animals and how this may relate to human disease. If we are able to understand how IGFBP-3 and IGFBP-5 affect the way cells respond to vitamin A and D, then we may be able to develop new ways to treat certain human diseases.Read moreRead less
Multi-Group Stochastic Modelling of Population Balance for Gas-Liquid Flows. Multiphase flow systems are encountered in many process industries such as chemical, petroleum, mining, nuclear, energy, food and pharmaceutical, which are fundamental to the Australian economy. Commercially available computer codes for simulating such systems are currently widely used in many Australian industrial sectors. This research project will address the prevalent deficiency in many of these computer codes and ....Multi-Group Stochastic Modelling of Population Balance for Gas-Liquid Flows. Multiphase flow systems are encountered in many process industries such as chemical, petroleum, mining, nuclear, energy, food and pharmaceutical, which are fundamental to the Australian economy. Commercially available computer codes for simulating such systems are currently widely used in many Australian industrial sectors. This research project will address the prevalent deficiency in many of these computer codes and develop new models capable of predicting a wide range of industrial bubbly flow problems. The resultant improved computer codes will provide industries with significant benefits and, in particular, reduce times and costs in their design and production. Read moreRead less
Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
Increasing innovation and flexibility in social service delivery. This project will use a comparative methodology to investigate how contracted social services require careful regulation to ensure service effectiveness and improved organisational capacity. The outcome will include a practice model for understanding the relationship between regulation, contract structure and forms of service delivery innovation.
Discovery Early Career Researcher Award - Grant ID: DE140100390
Funder
Australian Research Council
Funding Amount
$392,371.00
Summary
Urban inequality: The initiation and preservation of spatial privilege in Australia's elite suburbs. Increased spatial inequality in Australian cities since the 1970s has seen rising wealth in the wealthiest suburbs and increased poverty in the poorest. Investigating the drivers of such polarisation, this project will innovate by focusing on the wealthiest suburbs of Sydney and Melbourne. It will measure inequalities in access to services and investigate how affluent communities mobilise their f ....Urban inequality: The initiation and preservation of spatial privilege in Australia's elite suburbs. Increased spatial inequality in Australian cities since the 1970s has seen rising wealth in the wealthiest suburbs and increased poverty in the poorest. Investigating the drivers of such polarisation, this project will innovate by focusing on the wealthiest suburbs of Sydney and Melbourne. It will measure inequalities in access to services and investigate how affluent communities mobilise their financial means, family and social networks and negotiation skills to draw in investment in infrastructure and services. This project’s results will advance international analytical knowledge of urban dynamics and will inform planning and policy strategies to achieve more equitable distribution of services and infrastructure in metropolitan areas.Read moreRead less
Stewarding thin markets: improving public sector market effectiveness. This project aims to develop methodologies to identify thin markets in the public service sector. Thin markets, where there are a low number of buyers or low number of sellers, are a major risk for governments utilising a personalised approach to service delivery. This project will develop new methodologies for identifying thin markets and determine ways emerging markets can be stewarded to better achieve their aims.
Bushfires, social connectedness and mental health. The 2009 Victorian bushfires caused much loss of life, property destruction, and community disturbance. It is important for Promoting Better Health and Strengthening the Social and Economic Fabric that an accurate understanding is achieved of the factors that contribute to optimal recovery from natural disasters. This project will survey people affected by the fires over 5 years to both profile adaptation after the fires and to identify the i ....Bushfires, social connectedness and mental health. The 2009 Victorian bushfires caused much loss of life, property destruction, and community disturbance. It is important for Promoting Better Health and Strengthening the Social and Economic Fabric that an accurate understanding is achieved of the factors that contribute to optimal recovery from natural disasters. This project will survey people affected by the fires over 5 years to both profile adaptation after the fires and to identify the individual and community processes that influence outcome. This project being undertaken in partnership by academic, disaster management, health and community organisations will provide crucial information for shaping policy for disaster management in the years ahead.Read moreRead less
High Precision Silicon Pixel Detectors for High Energy Physics , Synchrotron and Medical Imaging Applications. Australia participates actively in the frontier field of high-energy particle physics to understand the fundamental building blocks of matter, their origins and interactions. This field excites the best minds in the scientific world and provides excellent training. To maintain our position in this field we must continue the development of the powerful instrumentation required for high- ....High Precision Silicon Pixel Detectors for High Energy Physics , Synchrotron and Medical Imaging Applications. Australia participates actively in the frontier field of high-energy particle physics to understand the fundamental building blocks of matter, their origins and interactions. This field excites the best minds in the scientific world and provides excellent training. To maintain our position in this field we must continue the development of the powerful instrumentation required for high-energy experiments. This project will satisfy that role. The application of particle detector expertise to state-of-the-art X-ray imaging detectors for the Australian Synchrotron and medical imaging is a perfect example of fundamental science tools applied to other fields. Australian Synchrotron experiments stand to gain much.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453432
Funder
Australian Research Council
Funding Amount
$257,250.00
Summary
Support for the Australian Experimental High Energy Physics Program. High energy particle physics studies the most fundamental constituents of matter. This microscopic frontier requires the highest energy and highest intensity particle accelerators. Through the Big Bang Model, high energy physics also sheds light on the development of the very early Universe. It is thus crucial for the understanding of nature at the very largest of scales as well as the very smallest.The ATLAS and Belle experime ....Support for the Australian Experimental High Energy Physics Program. High energy particle physics studies the most fundamental constituents of matter. This microscopic frontier requires the highest energy and highest intensity particle accelerators. Through the Big Bang Model, high energy physics also sheds light on the development of the very early Universe. It is thus crucial for the understanding of nature at the very largest of scales as well as the very smallest.The ATLAS and Belle experiments probe two of the most significant questions in fundamental physics: what is the origin of mass, and why do we live in a universe composed of matter rather than antimatter? This proposal seeks support to maintain access to the international high energy physics program in Europe and Japan.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0230224
Funder
Australian Research Council
Funding Amount
$220,255.00
Summary
Support for the Australian Experimental High Energy Physics Program. High energy particle physics studies the most fundamental constituents of matter. This microscopic frontier requires the highest energy and highest intensity particle accelerators. Through the Big Bang Model, high energy physics also sheds light on the development of the very early Universe. It is thus crucial for the understanding of nature at the very largest of scales as well as the very smallest. The ATLAS and Belle experim ....Support for the Australian Experimental High Energy Physics Program. High energy particle physics studies the most fundamental constituents of matter. This microscopic frontier requires the highest energy and highest intensity particle accelerators. Through the Big Bang Model, high energy physics also sheds light on the development of the very early Universe. It is thus crucial for the understanding of nature at the very largest of scales as well as the very smallest. The ATLAS and Belle experiments probe two of the most significant questions in fundamental physics: what is the origin of mass, and why do we live in a universe composed of matter rather than antimatter? This proposal seeks support to maintain access to the international high energy physics program in Europe and Japan.Read moreRead less