Regulation Of Receptors That Control Platelet Function Under Shear Stress
Funder
National Health and Medical Research Council
Funding Amount
$507,273.00
Summary
Specialized human blood cells that control blood loss and clotting (platelets) are currently difficult to test in the clinical laboratory, meaning patients are at risk of excessive bleeding or serious clot formation during disease or treatment. The aim of this proposal is to use our new reagents and assays to develop more reliable methods for evaluating relative bleeding or clotting risk in individuals.
Autoimmune-based thrombocytopenia can be a life-threatening adverse event associated with viral load, surgery, drug therapies or the use of the anticoagulant, heparin. This grant will define mechanisms of anti-platelet antibody-dependent platelet activation and assess shedding of platelet-specific glycoprotein (GP)VI as an immediate consequence of this activation, provide a new strategy for evaluating risk of thrombosis in HIT.
Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
The origins of electroreception and nocturnality in the earliest known jawed vertebrates and their bearing on vertebrate diversification. This project aims to discover primary new data to pinpoint the timing, anatomical origins and phylogenetic significance when two key sensory systems first appeared in modern vertebrates: electroreception and specialised nocturnal vision. Such abilities today allow high diversity of vertebrates to co-exist within the same geographical range, for example on trop ....The origins of electroreception and nocturnality in the earliest known jawed vertebrates and their bearing on vertebrate diversification. This project aims to discover primary new data to pinpoint the timing, anatomical origins and phylogenetic significance when two key sensory systems first appeared in modern vertebrates: electroreception and specialised nocturnal vision. Such abilities today allow high diversity of vertebrates to co-exist within the same geographical range, for example on tropical reefs or rainforest communities, through careful temporal niche partitioning where reliance on other sensory systems takes over from vision and olfaction as the principal method of prey detection. This project aims to elucidate how the modern fish diversity was shaped by such significant early evolutionary events.Read moreRead less
Black Hole Accretion: The Effects of Magnetic Fields and Radiation. This project represents a significant contribution by Australian researchers to one of Science's Big Questions: How do Black Holes channel gravitational energy into radiation at many different energies and into high speed outflows. It offers Australian Astronomy an opportunity to expand its endeavours into the rapidly growing and high profile areas of high-energy and computational astrophysics, injecting new expertise into the i ....Black Hole Accretion: The Effects of Magnetic Fields and Radiation. This project represents a significant contribution by Australian researchers to one of Science's Big Questions: How do Black Holes channel gravitational energy into radiation at many different energies and into high speed outflows. It offers Australian Astronomy an opportunity to expand its endeavours into the rapidly growing and high profile areas of high-energy and computational astrophysics, injecting new expertise into the interpretation of multi-wavelength data on accreting black holes. We will train a new cohort of internationally competitive students and early career researchers, equipping them with the advanced computational and modelling skills that are in increasingly higher demand in many technology-based industries.Read moreRead less
Pure and applied nuclear structure research with radioactive ion beams at Californium Rare Ion Breeder Upgrade (CARIBU). The structure of exotic neutron-rich nuclei will be investigated at the Californium Rare Ion Breeder Upgrade (CARIBU) radioactive ion beam facility using new and novel detector systems. The results will enhance our fundamental understanding of the atomic nucleus and stellar nucleosynthesis as well as provide important data for the development of next generation nuclear reactor ....Pure and applied nuclear structure research with radioactive ion beams at Californium Rare Ion Breeder Upgrade (CARIBU). The structure of exotic neutron-rich nuclei will be investigated at the Californium Rare Ion Breeder Upgrade (CARIBU) radioactive ion beam facility using new and novel detector systems. The results will enhance our fundamental understanding of the atomic nucleus and stellar nucleosynthesis as well as provide important data for the development of next generation nuclear reactors.Read moreRead less
Superdeformed nuclei and their decay: challenging nuclear models and probing quantum tunnelling. Nuclear superdeformation, where the atomic nucleus adopts an elongated, ellipsoidal shape and can undergo rapid rotation, offers a fascinating opportunity to study quantum mechanical effects in a system where single-particle and collective regimes overlap. The superdeformed shape itself is a spectacular example of collective motion in a mesoscopic system, while the rapid change to a sperhical shape ....Superdeformed nuclei and their decay: challenging nuclear models and probing quantum tunnelling. Nuclear superdeformation, where the atomic nucleus adopts an elongated, ellipsoidal shape and can undergo rapid rotation, offers a fascinating opportunity to study quantum mechanical effects in a system where single-particle and collective regimes overlap. The superdeformed shape itself is a spectacular example of collective motion in a mesoscopic system, while the rapid change to a sperhical shape is an excellent example of quantum-assisted tunnelling. The results of this project will shed light on this important process and provide a stringent test of our understanding of the nucleus.Read moreRead less
Studies On The Expression Of Muscarinic Receptors: Implications For The Pathology Of Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$498,791.00
Summary
Schizophrenia is a severe psychiatric disorder that affects approximately 1% of the population. This project will help define changes in the molecules in the brain of subjects with schizophrenia which are likely to be involved in two symptoms of the disorder, the psychoses and cognitive deficits. Understanding the cause of the cognitive deficits of schizophrenia is a high priority because they are the most disabilitating symptom of the disorder and do not respond to current drug treatments.
Sparse grid approximations and fitting using generalised combination techniques. Sparse grid techniques provide an effective tool to deal with the
computational curse of dimensionality which is a constant challenge in
modelling complex data. The proposed research is aimed at the
development and analysis of algorithms for data fitting with sparse
grids using variants of the combination technique. The outcome of the
research is a theory which will provide insights in the applicability,
limit ....Sparse grid approximations and fitting using generalised combination techniques. Sparse grid techniques provide an effective tool to deal with the
computational curse of dimensionality which is a constant challenge in
modelling complex data. The proposed research is aimed at the
development and analysis of algorithms for data fitting with sparse
grids using variants of the combination technique. The outcome of the
research is a theory which will provide insights in the applicability,
limitations and the convergence properties of the proposed
algorithms. The outcomes will be widely applicable in modelling of
large scale and complex data as is encountered in areas of
bioinformatics, physics and experimental studies of complex systems.
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Isomers as Probes of Nuclear Structure and Sources of Energetic Photons. The aim is to study exotic long-lived states in nuclei using accelerator facilities in Australia and overseas. This involves the development of sensitive instrumentation and will lead to a new understanding of how such states are formed, of how they may be used to identify the structure of exotic nuclei, and on the limits of stability of nuclei in general. Isomers represent a special form of nuclear matter and they play a r ....Isomers as Probes of Nuclear Structure and Sources of Energetic Photons. The aim is to study exotic long-lived states in nuclei using accelerator facilities in Australia and overseas. This involves the development of sensitive instrumentation and will lead to a new understanding of how such states are formed, of how they may be used to identify the structure of exotic nuclei, and on the limits of stability of nuclei in general. Isomers represent a special form of nuclear matter and they play a role in the formation of the elements in stellar nucleosynthesis. Stimulated isomer decay may ultimately lead to new forms of energy storage and gamma-ray lasers.Read moreRead less