Pathways To Prevention: The Effectiveness Of Universal And Selective Prevention In Altering Developmental Pathways To Alcohol And Cannabis Related Harms In Young Adults
Funder
National Health and Medical Research Council
Funding Amount
$465,967.00
Summary
This project will assess the potential long-term benefits for young Australians of two school-based drug prevention programs (Climate Schools and Preventure) compared to drug education as usual. This world-first study will inform national and international policy by evaluating whether prevention programs delivered in Year 8 are effective in reducing alcohol and cannabis related harms, including risk of aggression and violence, over the high risk period during young adulthood (ages 18-20).
Neuropathic pain is particularly difficult to treat and existing medications have considerable side effects. This project will develop a new set of glycine transport inhibitors that have the potential to provide pain relief without side effects.
Glycine Transporters regulate the concentration of glycine in the spinal cord and brain. It has been suggested that elevating glycine levels in these regions may be useful in treating pain and schizophrenia. This project will provide the basis for the development of new glycine transport inhibitors that may be used to treat these conditions.
Four Dimensional Epigenome Remodelling: Implications For Endocrine Resistance In Breast Cancer
Funder
National Health and Medical Research Council
Funding Amount
$828,560.00
Summary
Patients with estrogen receptor positive breast cancer receive endocrine therapy, however half fail to respond and relapse. Endocrine resistant breast cancer currently represents the most significant challenge to breast cancer treatment. We suggest that three-dimensional epigenetic remodelling is an underlying mechanism that determines endocrine sensitivity that we will exploit as a novel therapeutic strategy to effectively treat patents with recurrent disease.
The Structural Basis For Promiscuity Of Drug Binding To HERG K+ Channels
Funder
National Health and Medical Research Council
Funding Amount
$713,035.00
Summary
Special proteins called ion channels control the electrical activity of the heart. Drugs that block ion channels can have the unwanted side-effect of altering the rhythm of the heart beat and causing sudden cardiac death. Extensive efforts are made to screen for this problem during drug development but it is still an inexact science. Here we will use high resolution imaging technologies to get a better understanding of how drugs bind to ion channel proteins.
The Effectiveness Of A Comprehensive ‘universal’ And ‘targeted’ Intervention To Prevent Substance Use And Related Harms In Adolescents: The CAP Project
Funder
National Health and Medical Research Council
Funding Amount
$755,906.00
Summary
Alcohol and other drug use are common amongst Australian adolescents and the disability associated with this use is considerable. Prevention is clearly needed, yet we have few models of well implemented prevention programs that are effective in maximisising prevention outcomes.The current proposal addresses this gap by evaluating a novel approach to preventing substance use and related harms in adolescents by combining effective 'universal' and 'targeted' school-based prevention programs in a su ....Alcohol and other drug use are common amongst Australian adolescents and the disability associated with this use is considerable. Prevention is clearly needed, yet we have few models of well implemented prevention programs that are effective in maximisising prevention outcomes.The current proposal addresses this gap by evaluating a novel approach to preventing substance use and related harms in adolescents by combining effective 'universal' and 'targeted' school-based prevention programs in a sustainable delivery platform.Read moreRead less
An economic analysis of multi-period reform programs. This project aims to use a mechanism design approach to study multi-period reform programs and their use in the transition from status quo institutions. The project intends to shed light on the difficulties of introducing efficiency enhancing long-term policies. Expected outcomes include theoretical models that incorporate adjustment costs, common values, and complicated status quo institutions into models of economic reform from a mechanism ....An economic analysis of multi-period reform programs. This project aims to use a mechanism design approach to study multi-period reform programs and their use in the transition from status quo institutions. The project intends to shed light on the difficulties of introducing efficiency enhancing long-term policies. Expected outcomes include theoretical models that incorporate adjustment costs, common values, and complicated status quo institutions into models of economic reform from a mechanism design perspective as well as optimal dynamic reform policies in the presence of these frictions, focusing attention in the trade-off between static efficiency and dynamic welfare gains. Intended benefits include insights that are wildly applicable to the provision of public infrastructure and management of public resources.Read moreRead less
Designing offices well. This project aims to describe, quantify and analyse the impact of workspace design on workers’ satisfaction, productivity and health. The Australian market is the fastest adopter of Activity-Based Working (ABW) in the world and impacts arising from this workspace typology on workers will be significant now and in the next decade. This project will develop benchmarking for ABW offices, techniques for monitoring cognitive performance in situ, and design guidelines for healt ....Designing offices well. This project aims to describe, quantify and analyse the impact of workspace design on workers’ satisfaction, productivity and health. The Australian market is the fastest adopter of Activity-Based Working (ABW) in the world and impacts arising from this workspace typology on workers will be significant now and in the next decade. This project will develop benchmarking for ABW offices, techniques for monitoring cognitive performance in situ, and design guidelines for health promotion. By shifting attention to design features that actually perform well, this project will provide the empirical basis needed to transform the way workspaces are designed now and in the future. It will therefore lead to greater productivity in and among workplaces.Read moreRead less
Stage acoustical quality in auditoria: measurement, simulation, prediction and design. This project asks what acoustic qualities make a concert hall stage outstanding for musicians, and how can these qualities be achieved? It involves a collaboration between acoustics researchers in Australia and Korea, with complementary expertise in lab and field studies of auditorium stages.
Assessing Architectural Aesthetic Character: An ‘Intelligent’ Approach. This project aims to develop ground-breaking insights and software to improve the assessment of architectural aesthetic character by Australia’s designers, councils and courts.
Combining empirical, neurophysiological and machine-learning approaches, this project expects to provide a new level of robustness and repeatability in administrative and legal assessments of building aesthetics.
Planned outcomes include: (i) a uni ....Assessing Architectural Aesthetic Character: An ‘Intelligent’ Approach. This project aims to develop ground-breaking insights and software to improve the assessment of architectural aesthetic character by Australia’s designers, councils and courts.
Combining empirical, neurophysiological and machine-learning approaches, this project expects to provide a new level of robustness and repeatability in administrative and legal assessments of building aesthetics.
Planned outcomes include: (i) a unique quantitative understanding of aesthetic assessment and (ii) a world-first method for measuring and comparing the character of buildings.
This research has the potential to reduce the substantial cost of disputes and provide more certainty and efficiency in the architectural design, approval and appeal processes.
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