Selective Estrogen Receptor Modulators (SERMs) - A Potential New Treatment For Women Of Child-bearing Age With Psychotic Symptoms Of Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$210,480.00
Summary
Schizophrenia is a devastating illness urgently requiring a new treatment approach. We have discovered that estrogen is an effective treatment for women with schizophrenia and are currently trialling a safer Selective Estrogen Receptor Modulator (SERM) known as brain estrogen� in postmenopausal women with schizophrenia. Regulatory permission is now available to trial the SERM in younger women, and we seek to extend our current SERM study into child bearing age women with schizophrenia.
A Randomised Stepped Wedge Trial Of The Scaling Up Of A Community Based Alcohol Education Program In Rural Sri Lankan Villages And Its Effects On Alcohol Use, And Associated Harms, Depression And Social Capital.
Funder
National Health and Medical Research Council
Funding Amount
$825,364.00
Summary
Alcohol use is major problem in much of rural Asia. In addition to direct effects on health it is major contributor to suicide, domestic violence and poverty. Much of the alcohol consumed is illicit and so consumption is not influenced by regulation or taxation. This is a trial of a community intervention in rural Sri Lanka to reduce alcohol use and alcohol related disorders that uses participatory drama in conjunction with previously trialed educational materials.
The RADAR Project: Identifying Early Warning Signals On The Pathways To Alcohol Use Disorder
Funder
National Health and Medical Research Council
Funding Amount
$884,321.00
Summary
The transition from alcohol initiation to an alcohol use disorder is a crucial yet under-studied research area. The current project will characterise the natural history of alcohol use disorder and identify modifiable factors that increase or decrease the likelihood of developing an alcohol use disorder once alcohol use begins. This information will guide prevention of, and early intervention for, this disabling disorder.
Indigenous Mental Health Model Of Care: RCT Based On A Trans-diagnostic CBT Program Co-designed With Community
Funder
National Health and Medical Research Council
Funding Amount
$996,217.00
Summary
We propose to develop an Indigenous Model of Mental Health Care (IMMHC) that encompasses psychological therapy and cultural healing practices developed in consultation with local, participating Indigenous communities, that will for the first time treat highly prevalent mood and anxiety disorders in Indigenous Australians.
How iron is cycled in Southern Ocean waters. This project aims to probe the Southern Ocean phytoplankton’s ability to take up and retain iron, using iron isotope tracer techniques. The Southern Ocean regulates Earth's climate, but the supply of iron to Southern Ocean surface waters is low, restricting the ability of phytoplankton to flourish and draw down carbon dioxide. The results are expected to reveal survival strategies of phytoplankton in this iron-poor environment and their potential abil ....How iron is cycled in Southern Ocean waters. This project aims to probe the Southern Ocean phytoplankton’s ability to take up and retain iron, using iron isotope tracer techniques. The Southern Ocean regulates Earth's climate, but the supply of iron to Southern Ocean surface waters is low, restricting the ability of phytoplankton to flourish and draw down carbon dioxide. The results are expected to reveal survival strategies of phytoplankton in this iron-poor environment and their potential ability to adapt to environmental change. This knowledge could be used to develop models to manage this climate-sensitive region.Read moreRead less
Early Intervention For Anxiety And Phobic Disorders In Young Children With Intellectual Disability
Funder
National Health and Medical Research Council
Funding Amount
$305,674.00
Summary
Children with intellectual disability (ID) are 2-3 times more likely to have behavioural and emotional disturbance, including anxiety and fears, than children of normal intellectual ability. Anxiety problems are a source of distress for the child, impair their ability to learn and are a cause of family burden and community cost. Therefore, effective interventions are urgently required. Research with non-disabled children has demonstrated the effectiveness of teaching parents to manage their chil ....Children with intellectual disability (ID) are 2-3 times more likely to have behavioural and emotional disturbance, including anxiety and fears, than children of normal intellectual ability. Anxiety problems are a source of distress for the child, impair their ability to learn and are a cause of family burden and community cost. Therefore, effective interventions are urgently required. Research with non-disabled children has demonstrated the effectiveness of teaching parents to manage their child's anxiety, however the effectiveness of this approach in children with ID has not yet been established. This project aims to compare the relative effectiveness of two intervention conditions compared to a waiting list group, for highly anxious children aged 4-7 years with ID. One intervention will teach parents to help their child deal with anxiety problems, and develop skills to overcome their own associated emotional upset and family and social problems. The other intervention will provide non-directive counselling and support to help the parents understand the nature and causes of ID, associated anxiety problems in the child, and parent and family stress. The long term outcome of these two interventions will be assessed by following the children and their families for two years. A manual of each treatment is produced. This project aims to provide evidence for a relatively inexpensive, feasible and effective early intervention program for young children with ID at risk for developing anxiety problems that can be easily taught to professionals and is acceptable to parents. Widespread use of this intervention has the potential to reduce the added burden and cost to families and the community of persistent severe anxiety in young people with ID.Read moreRead less
The effect of cochlear implants on cognitive decline in ageing Australians. This project aims to investigate the impact of cochlear implants on cognitive function in elderly people with deafness. Deafness has been found to be independently associated with a 30–40 per cent accelerated rate of cognitive decline in elderly adults. There is currently no effective treatment for cognitive decline. The intended outcomes of this observational study will help us to understand the biological process of co ....The effect of cochlear implants on cognitive decline in ageing Australians. This project aims to investigate the impact of cochlear implants on cognitive function in elderly people with deafness. Deafness has been found to be independently associated with a 30–40 per cent accelerated rate of cognitive decline in elderly adults. There is currently no effective treatment for cognitive decline. The intended outcomes of this observational study will help us to understand the biological process of cognitive decline, whether hearing loss is causal, and whether the process can be altered. These findings should be applicable to all individuals with hearing loss. If cochlear implants delay cognitive decline, this would significantly affect policy, quality of life for the elderly, and the cost to society.Read moreRead less
High resolution health assessment of Antarctic plants as climate changes. Declines in terrestrial ecosystem health as a result of a drying climate have been observed in some areas of East Antarctica. This project aims to determine if such changes are widespread. Since mosses, the dominant plants of Antarctica, preserve a record of past climate down their shoots they can be used as surrogates to study how both ecosystems and climate are changing at remote polar sites. Outcomes will include improv ....High resolution health assessment of Antarctic plants as climate changes. Declines in terrestrial ecosystem health as a result of a drying climate have been observed in some areas of East Antarctica. This project aims to determine if such changes are widespread. Since mosses, the dominant plants of Antarctica, preserve a record of past climate down their shoots they can be used as surrogates to study how both ecosystems and climate are changing at remote polar sites. Outcomes will include improved climate data for Antarctica, enabling more robust analysis of regional climate change, and development of ultrahigh-resolution techniques capable of non-destructively monitoring Antarctic ecosystem health. This research will advance ecosystem science and inform best practice in management of Antarctic biodiversity.Read moreRead less
From Brain Maps To Mechanisms: Modeling The Pathophysiology Of Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$320,891.00
Summary
My Fellowship will develop a framework that integrates brain imaging data with mathematical models of the brain to help understand the mechanisms responsible for schizophrenia. By linking functional Magnetic Resonance Imaging (fMRI) measurements to models of their underlying causes, the work may lead to new treatments that target the specific dysfunction in individuals with this debilitating brain disorder.
Australian Laureate Fellowships - Grant ID: FL0992409
Funder
Australian Research Council
Funding Amount
$2,996,243.00
Summary
The neural bases of decision-making. This research focuses on the neural bases of decision making, a general capacity affected by normal ageing, disorders associated with neurodegeneration including dementia, major psychiatric conditions and drug addiction. Changes in the neural systems that result in the cognitive and emotional dissociation reflected in these disorders constitute the highest health, economic and social capital attrition burden to Australia of any disease group, a burden that is ....The neural bases of decision-making. This research focuses on the neural bases of decision making, a general capacity affected by normal ageing, disorders associated with neurodegeneration including dementia, major psychiatric conditions and drug addiction. Changes in the neural systems that result in the cognitive and emotional dissociation reflected in these disorders constitute the highest health, economic and social capital attrition burden to Australia of any disease group, a burden that is only predicted to increase as the population ages. Understanding these changes in neural systems and their specific behavioural effects is, therefore, of critical importance and will ultimately provide new targets for treatment and rehabilitation.Read moreRead less