Defining The Clinical Role Of Topiramate In The Treatment Of Alcohol Dependence In Australia
Funder
National Health and Medical Research Council
Funding Amount
$718,836.00
Summary
We urgently require new strategies for the treatment of alcohol dependence. The effectiveness of currently approved alcohol medications is limited. Emerging data suggests that topiramate has robust effectiveness and that better medicine selection is possible for patients based on their genotype. We propose to conduct a double-blind randomised controlled trial to examine the clinical and cost effectiveness of topiramate using a genetically based personalised approach.
Progressing Life Course Research In Psychiatric Epidemiology
Funder
National Health and Medical Research Council
Funding Amount
$331,674.00
Summary
Mental health and alcohol disorders are major public health problems which cause long-term disabilities, poor health and early mortality. Addressing these problems requires a better understanding of the early factors leading to these disorders. This research program represents a unique opportunity to increase our knowledge of the origins of these disorders and significantly contribute to improved mental health and alcohol prevention policies and programs.
The Relationship Between Cannabis Use And Symptoms And Relapse In Psychosis
Funder
National Health and Medical Research Council
Funding Amount
$169,604.00
Summary
Cannabis is increasingly widely used and abused by young people. Use in young people with schizophrenia is even more extensive. There is some suggestion that this drug use is a result of their illness, ie to reduce unpleasant symptoms or feelings. Equally the drug may contribute to their psychosis. This study aims to assess the degree to which psychosis may be caused by cannabis use in vulnerable young people.
Increasing Knowledge About Substance Use, Mental Health And Harms, And Interventions To Prevent And Reduce Harm
Funder
National Health and Medical Research Council
Funding Amount
$849,540.00
Summary
This Fellowship comprises three programmes of work: 1. epidemiology of illicit drug use (including the natural history of use: incidence, prevalence, persistence, desistance and relapse), contribution to the burden of disease; 2. Pharmaceutical opioids, the impact of opioid dependence, and treatments to reduce harm; 3. Risk and resilience in young people. This work will inform prevention, early intervention and treatment initiatives.
Alcohol And Other Drug Treatment Funding, Purchasing And Workforce: Empirical Analyses To Inform Policy
Funder
National Health and Medical Research Council
Funding Amount
$473,865.00
Summary
Alcohol and drug treatment works: it improves health and reduces the social impact of alcohol and drug use. The treatment itself is not, however, the only variable that impacts on whether health outcomes are improved. The way in which governments fund, purchase and structure the treatment service system is also important. This study will empirically test the relationship between treatment outcome and the structures that governments put in place, providing new evidence to inform decision-making.
Pharmaceutical Opioid Analgesic (POA) Dependence And Treatment Responses
Funder
National Health and Medical Research Council
Funding Amount
$390,628.00
Summary
Dependence on opioid based pain medication is a rapidly growing health concern in Australia. In the United States more people die each year from misusing pain medication than from using illicit drugs like heroin. Dr Suzanne Nielsen, an emerging expert in pharmaceutical misuse, will undertake essential research to understand the dependence to opioid pain medication in Australia and to develop appropriate treatment responses.
Psychosocial Disorders Of Youth: A Population-based Prospective Study Into Young Adulthood
Funder
National Health and Medical Research Council
Funding Amount
$450,939.00
Summary
Much earlier work in adults has pointed to the teens as a common point at which many of the important causes of chronic disease and disability in adults begin. These include problems such as tobacco use, depression and anxiety disorders, obesity, alcohol abuse and illicit drug use. However, only a prospective study is able to clarify to what extent common health risk behaviours of teenagers pose a threat to later health and well-being and what characteristics indicate those most likely to go on ....Much earlier work in adults has pointed to the teens as a common point at which many of the important causes of chronic disease and disability in adults begin. These include problems such as tobacco use, depression and anxiety disorders, obesity, alcohol abuse and illicit drug use. However, only a prospective study is able to clarify to what extent common health risk behaviours of teenagers pose a threat to later health and well-being and what characteristics indicate those most likely to go on to problems such as nicotine dependence, recurrent depression and illicit drug abuse. The proposal deals with the follow-up ten years on of a representative sample of 2000 Victorian teenagers. Seven earlier waves of data collections have ascertained levels and risk factors for common behavioural and mental health problems in the teens and early twenties. These problems included depression and anxiety, smoking, heavy alcohol consumption, illicit drug use, deliberate self-harm, obesity, eating disorder, sexually risky behaviour, intravenous drug use, antisocial behaviours and accidental injury. This follow-up of participants at the age of 24 to 25 years will ascertain persisting rates of these problems including levels of substance dependence and mental disorder. Social outcomes such as educational achievement, employment, relationships, parenthood and friendships will be ascertained. In addition mouth washes will be used to collect DNA to allow investigation of genes that may make a contribution to more severe mental disorder and substance dependency. This study will give a clear picture of the outcome and consquences of common adolescent health problems. It will also clarify further psychosocial factors that contribute to their onset or outcome. Together with an analysis of candidate genes the study should make a great contribution to the information necessary for planning effective preventive intervention.Read moreRead less
Opioid Dependent Persons In Pharmacotherapy: Blood Borne Viruses And Cancer Risk
Funder
National Health and Medical Research Council
Funding Amount
$88,495.00
Summary
Opioid dependent persons in pharmacotherapy in NSW are at increased risk of death from cancer. We will examine the occurrence of infection with hepatitis and HIV among this high-risk population using data linkage. We will define the relationship between infection, the duration, frequency and type of pharmacotherapy, and cancer risk. The findings will guide effective strategies that will reduce cancer incidence and mortality among this group, and minimise the associated health care costs.
Young Adult Social Transitions - Course Of Mental And Behavioural Disorders:The Victorian Adolescent Health Cohort Study
Funder
National Health and Medical Research Council
Funding Amount
$560,750.00
Summary
The paths young people follow into adulthood have changed markedly in the past three decades. Traditionally the adoption of a role as marital partner, parent and fulltime employee in the late teens and early twenties was accompanied by a diminution or 'maturing out' of health risk behaviours and emotional problems arising in adolescence. The social transitions into adulthood are now both delayed and in many instances changed with higher rates of cohabitation, extended teriary educational partici ....The paths young people follow into adulthood have changed markedly in the past three decades. Traditionally the adoption of a role as marital partner, parent and fulltime employee in the late teens and early twenties was accompanied by a diminution or 'maturing out' of health risk behaviours and emotional problems arising in adolescence. The social transitions into adulthood are now both delayed and in many instances changed with higher rates of cohabitation, extended teriary educational participation and part-time employment. The effect of these social changes on health risk behaviours, behavioural and mental disorders is uncertain. This proposal will undertake a further follow-up in the late twenties of a group of just under 2000 young Victorians, already studied from the age of 14 years through to the age of 24 years. This study will assess the persistence of behavioural problems such as smoking and nicotine dependence, excessive alcohol consumption and dependence, cannabis dependence, illicit drug use, risk sexual behaviour, depression and anxiety disorders. The extent to which these may be associated with successful negotiation of transitions in education, employment, relationships, parenthood and establishing an independent home will be evaluated. Alternative explanations including the severity of dependence syndrome, personality, social background and genetic risk factors will also be explored.Read moreRead less
Impact Of Parental Alcohol, Tobacco And Other Substance Use On Infant Development And Family Functioning
Funder
National Health and Medical Research Council
Funding Amount
$1,996,525.00
Summary
The current study will be the first large-scale Australian birth cohort study to comprehensively examine the effects of substance use in pregnant women and their partners during the prenatal period on infant developement and family functioning. Dramatically improved knowledge of these effects will provide evidence-based direction to the development of public health policy and community interventions that aim to improve the health and wellbeing of Australian children and families.