Anion Binding and Sensing With Self-Assembled Metallo-Supramolecular Assemblies. Anions are of particular significance in several areas relating to the day-to-day lives of Australians; for example as contaminants in waterways and nuclear waste streams, as indicators of chemical weapons, and as antagonists in biological systems. The proposed research programme will investigate a relatively unexplored approach to binding and sensing anions. This will further research in the area of supramolecular ....Anion Binding and Sensing With Self-Assembled Metallo-Supramolecular Assemblies. Anions are of particular significance in several areas relating to the day-to-day lives of Australians; for example as contaminants in waterways and nuclear waste streams, as indicators of chemical weapons, and as antagonists in biological systems. The proposed research programme will investigate a relatively unexplored approach to binding and sensing anions. This will further research in the area of supramolecular chemistry, providing additional research expertise in this rapidly progressing area of the chemical sciences. In terms of Breakthrough science the targeted assemblies will shed further light on self-assembly processes involving ligands with different domains, placing Australian research at the forefront of such investigations.Read moreRead less
Internally decorated discrete Metallo-supramolecular Assemblies and infinite Metal-Organic Frameworks as molecular containers. In the macroscopic world, containers are used to hold, provide physical protection, or create a modified environment for their contents. This project will result in the synthesis of novel molecular container materials that provide decorated internal surfaces capable of selectively binding chemical species. In addition to the breakthrough scientific benefits of establish ....Internally decorated discrete Metallo-supramolecular Assemblies and infinite Metal-Organic Frameworks as molecular containers. In the macroscopic world, containers are used to hold, provide physical protection, or create a modified environment for their contents. This project will result in the synthesis of novel molecular container materials that provide decorated internal surfaces capable of selectively binding chemical species. In addition to the breakthrough scientific benefits of establishing the fundamentals of these systems, the binding of chemicals, which are environmental contaminants, will provide the grounding for applications that will contribute to the national priority of 'Frontier technologies'. Furthermore, this research will lead to the training of the next generation of Australian scientists by quality international researchers.Read moreRead less
Complex nano-systems for highly selective imaging and targeting of cells. The aim of the project is to design multi-functional nanoparticles that can be tracked by multiple bio-imaging techniques, such as magnetic resonance imaging (MRI) and positron emission tomography imaging. The nanoparticles are designed to be targetable to specific cell populations and capable of delivering drugs. The project plans to concentrate the MRI-active gadolinium into nanoparticles to generate enhanced images, and ....Complex nano-systems for highly selective imaging and targeting of cells. The aim of the project is to design multi-functional nanoparticles that can be tracked by multiple bio-imaging techniques, such as magnetic resonance imaging (MRI) and positron emission tomography imaging. The nanoparticles are designed to be targetable to specific cell populations and capable of delivering drugs. The project plans to concentrate the MRI-active gadolinium into nanoparticles to generate enhanced images, and to combine this with other imaging modalities to facilitate tracking and sensitivity. Expected outcomes would enable a new approach to extremely accurate and sensitive imaging of tumours to enable the imaging of much smaller tumours than currently possible. This would allow early therapeutic intervention. The nanoparticles are also designed to deliver a therapeutic payload to specific locations, avoiding systemic delivery of toxic anticancer drugs.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100088
Funder
Australian Research Council
Funding Amount
$700,000.00
Summary
nano infrared and sub micron Raman spectroscopy and imaging. Nano infrared and sub micron raman spectroscopy and imaging: Near-field Infrared (IR) spectroscopy and imaging systems will be coupled to near-field scanning optical microscopes to provide IR spectroscopy and molecular images at less than 20 nanometre lateral resolution. This is unprecedented resolution for infrared fingerprinting and molecular imaging. For two months a year the spectroscopy system will be coupled to the IR beamline at ....nano infrared and sub micron Raman spectroscopy and imaging. Nano infrared and sub micron raman spectroscopy and imaging: Near-field Infrared (IR) spectroscopy and imaging systems will be coupled to near-field scanning optical microscopes to provide IR spectroscopy and molecular images at less than 20 nanometre lateral resolution. This is unprecedented resolution for infrared fingerprinting and molecular imaging. For two months a year the spectroscopy system will be coupled to the IR beamline at the Australian synchrotron, to provide full IR spectral coverage available to all Australian and New Zealand scientists. A confocal raman spectrometer will be upgraded to the ultraviolet to provide spectra at less than 150 nanometre resolution. These systems will provide a unique Australian resource for nanoscientists, biomedical researchers and materials scientists requiring molecular information on the nanoscale.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100087
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
Regional Facility for Molecular Characterisation and Mapping. Researchers at the Schools of Chemistry at The Australian National University and University of Wollongong are involved in a range of projects where new molecules are synthesised or discovered in natural products such as rainforest plants and marine organisms. Some of the molecules have already shown promise against diseases such as Alzheimer's and cardiovascular disease. In order to fully characterise these molecules, two complementa ....Regional Facility for Molecular Characterisation and Mapping. Researchers at the Schools of Chemistry at The Australian National University and University of Wollongong are involved in a range of projects where new molecules are synthesised or discovered in natural products such as rainforest plants and marine organisms. Some of the molecules have already shown promise against diseases such as Alzheimer's and cardiovascular disease. In order to fully characterise these molecules, two complementary mass spectrometers, replacing ageing instrumentation will be commissioned at each site. In addition, researchers in Wollongong will acquire a MALDI mass spectrometer capable of imaging the distribution of molecules on tissues that may be pathologically important.Read moreRead less
Designing and Building Novel 2D Hybrid Materials. The aim of this project is to use computational and experimental techniques to discover and fabricate new hybrid materials. Single-layer (2-D) materials like graphene have gained prominence and new ones are constantly being reported. Hybrid materials built from combinations of 2-D layers are appearing but progress is slow. This project is designed to increase the rate of discovery and fabrication of hybrids. The outcome would be an extensive data ....Designing and Building Novel 2D Hybrid Materials. The aim of this project is to use computational and experimental techniques to discover and fabricate new hybrid materials. Single-layer (2-D) materials like graphene have gained prominence and new ones are constantly being reported. Hybrid materials built from combinations of 2-D layers are appearing but progress is slow. This project is designed to increase the rate of discovery and fabrication of hybrids. The outcome would be an extensive database of materials properties, clear direction on how to control material properties, and manufacturing protocols to build a wide range of new materials.Read moreRead less
Design and Fabrication of 2D Hybrid Materials. There are >300 2D materials like graphene with potentially exotic and useful electrooptic and superconductor properties that will drive novel industrial applications. This project aims to use advanced computational and experimental techniques to discover and fabricate new 2D hybrid materials built from different layers of 2D materials. This approach is essential as the number of possible hybrids is huge (millions) and current processes to identify a ....Design and Fabrication of 2D Hybrid Materials. There are >300 2D materials like graphene with potentially exotic and useful electrooptic and superconductor properties that will drive novel industrial applications. This project aims to use advanced computational and experimental techniques to discover and fabricate new 2D hybrid materials built from different layers of 2D materials. This approach is essential as the number of possible hybrids is huge (millions) and current processes to identify and build 2D hybrids are technically challenging and slow. Expected outcomes include defining a new paradigm for efficient identification and synthesis of 2D hybrids with exotic, bespoke properties. The generation of a large database of materials for researchers/industry would be of wide benefit.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100027
Funder
Australian Research Council
Funding Amount
$320,000.00
Summary
Sensitive and multinuclear: a dedicated facility for high-throughput characterisation of small molecules. This project will provide new cutting edge nuclear magnetic resonance equipment will enhance an existing shared analysis facility based at University of New South Wales. The new equipment will underpin research in polymers, neuropharmacology, the biological basis of inherited disease, nanomedicine, bioactive compounds and toxins.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0346733
Funder
Australian Research Council
Funding Amount
$399,466.00
Summary
Ultra-Sensitive CCD Diffractometer with High Intensity X-ray Photon Generator. X-ray photon diffraction from single crystals provides the most accurate, precise and detailed three dimensional chemical structure information. It is however often difficult to obtain crystals of complex chemical assemblies, such as those used in nanotechnology and photon technology, suitable for diffraction analysis using equipment currently available at Australian chemical crystal structure facilities. The collab ....Ultra-Sensitive CCD Diffractometer with High Intensity X-ray Photon Generator. X-ray photon diffraction from single crystals provides the most accurate, precise and detailed three dimensional chemical structure information. It is however often difficult to obtain crystals of complex chemical assemblies, such as those used in nanotechnology and photon technology, suitable for diffraction analysis using equipment currently available at Australian chemical crystal structure facilities. The collaborating institutions seek to overcome this problem by purchasing a high sensitivity CCD area detector coupled to an intense laboratory source of X-ray photons. The installation of the equipment would be the first of its kind at an Australian facility and only the fourth worldwide.Read moreRead less