Decoding the molecular components of aquatic parasite-host interactions. This project aims to further understand the molecular components that regulate aquatic host-parasite interactions which contributes to many diseases worldwide. Aquatic parasites rely on chemical cues to locate and infect their host. This project will target the aquatic host-parasite interaction to decipher these chemical cues, so that future tools may be developed to suppress this interplay. This project expects to contribu ....Decoding the molecular components of aquatic parasite-host interactions. This project aims to further understand the molecular components that regulate aquatic host-parasite interactions which contributes to many diseases worldwide. Aquatic parasites rely on chemical cues to locate and infect their host. This project will target the aquatic host-parasite interaction to decipher these chemical cues, so that future tools may be developed to suppress this interplay. This project expects to contribute imperative basic knowledge for the future control of the intestinal parasite disease, Schistosomiasis, a devastating tropical disease.Read moreRead less
Modulating Inflammatory And Fibrogenic Pathways In Kidney Disease Using A Novel Antagonist Of Protease-Activated-Receptor-2
Funder
National Health and Medical Research Council
Funding Amount
$581,116.00
Summary
Chronic kidney disease (CKD) now affects 10% of adults in industrialised countries. Current treatments are largely ineffective. Thus developing better CKD treatments will have substantial public health benefit. Three well established and clinically relevant animal models of kidney disease will be used to test the ability of a new experimental anti-inflammatory drug, developed by members of this research team at The University of Queensland, to prevent or lessen the progression of CKD.
Cellular Regulation Of Receptor Signalling And Cytokine Responses
Funder
National Health and Medical Research Council
Funding Amount
$859,288.00
Summary
Cell surface receptors and signalling pathways elicit the release of cytokines, or chemical messengers, to control inflammation, which is the body’s response to infection or danger. We have discovered a new signalling pathway that can turn off inflammation and help prevent inflammatory disease. Our studies will now define the molecular details of this pathway and show how new and existing drugs targeting this pathway can be optimally used to treat inflammation and cancer.
Evolved enzymes and biomimetics for organophosphate degradation. Organophosphate (OP) pesticides are an indispensable part of modern agriculture - their use results in dramatically increased crop yields. However, they are toxic and can damage the environment and cause significant health problems. This project intends to evolve enzymes capable of dealing with problems caused by OPs.
Macrophages are important cells at the front-line of immunity where one of their main roles is to release anti-bacterial proteins. We will study the macrophage molecules, subcellular organelles and pathways that help to release these proteins to kill bacteria and fight infection. Our studies will identify new cellular targets for boosting immunity and treating inherited diseases with defective macrophage function.
Carbon-based electrode materials for electrochemical energy storage and water desalination. Clean energy and water resource are two critical issues for an environmentally sustainable Australia. The research project will lead to the discovery of innovative carbon-based electrode materials with well-designed physical and chemical properties for clean energy storage and alternative water desalination technology.