Diagnosing river health using invertebrate traits and DNA barcodes. Diagnosing river health using invertebrate traits and DNA barcodes. This project aims to develop indices that link change in invertebrate communities to specific environmental stressors, and combine these indices with innovative, low cost molecular approaches to species identification to rapidly identify the causes of decline. River health assessment methods, usually based on aquatic invertebrates, identify if rivers are impaire ....Diagnosing river health using invertebrate traits and DNA barcodes. Diagnosing river health using invertebrate traits and DNA barcodes. This project aims to develop indices that link change in invertebrate communities to specific environmental stressors, and combine these indices with innovative, low cost molecular approaches to species identification to rapidly identify the causes of decline. River health assessment methods, usually based on aquatic invertebrates, identify if rivers are impaired but must be developed to identify the causes of decline. The intended outcomes are improved sustainable water resource management within and among states, and improved natural resource policy development.Read moreRead less
Circular Plant Proteins with Pharmaceutical Applications. The proposed research will develop methods for using plants as protein production factories. Initially I will use plants to create engineered cyclotides that incorporate peptides with proven therapeutic activity against cancer and multiple sclerosis. Successful production of therapeutic proteins in plants will benefit Australians by making treatments for these and other diseases more accessible. It also has the potential for a major econo ....Circular Plant Proteins with Pharmaceutical Applications. The proposed research will develop methods for using plants as protein production factories. Initially I will use plants to create engineered cyclotides that incorporate peptides with proven therapeutic activity against cancer and multiple sclerosis. Successful production of therapeutic proteins in plants will benefit Australians by making treatments for these and other diseases more accessible. It also has the potential for a major economic benefit from the sales of Australian-based drugs. This proposal will also provide outstanding research training for graduate students in multidisciplinary methods that constitute state-of the-art structural and plant molecular biology.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH220100017
Funder
Australian Research Council
Funding Amount
$4,808,669.00
Summary
ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals. Radiopharmaceuticals are emerging as next generation medical technologies for addressing complex health challenges, and their manufacture offers significant economic benefit to Australia. The ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals (AMTAR) aims to establish a manufacturing platform for new medical technologies combining innovations in biotechnology and pharmaceutical science. The progra ....ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals. Radiopharmaceuticals are emerging as next generation medical technologies for addressing complex health challenges, and their manufacture offers significant economic benefit to Australia. The ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals (AMTAR) aims to establish a manufacturing platform for new medical technologies combining innovations in biotechnology and pharmaceutical science. The program addresses industry-led challenges for translation of biologics as molecular radiopharmaceuticals, building capacity in biomanufacturing, radiobiology and radiochemistry. The program establishes a dedicated manufacturing pipeline, future-proofing production and securing supply chain of next generation medical technologies.Read moreRead less
In vitro expression of macrocyclic peptides. This project aims to develop a novel strategy for the production of polypeptides with unnatural chemical groups using a sense codon reassignment approach. Novel peptides could be used in a range of pharmaceutical applications. Peptides made of 20 natural amino acids cover only a very small fraction of the available chemical and functional space. While a peptide’s functionality can be extended with unnatural amino acids, the methods for their site-sele ....In vitro expression of macrocyclic peptides. This project aims to develop a novel strategy for the production of polypeptides with unnatural chemical groups using a sense codon reassignment approach. Novel peptides could be used in a range of pharmaceutical applications. Peptides made of 20 natural amino acids cover only a very small fraction of the available chemical and functional space. While a peptide’s functionality can be extended with unnatural amino acids, the methods for their site-selective incorporation are inefficient. The project’s strategy relies on the depletion of selected tRNAs from an in vitro protein translation system and their replacement with synthetic tRNAs, charged with unnatural amino acids. It is expected that the developed technology could be used to rapidly generate and screen highly diversified macrocyclic peptide libraries.Read moreRead less
Early Career Industry Fellowships - Grant ID: IE230100245
Funder
Australian Research Council
Funding Amount
$460,237.00
Summary
Transforming wastewater services in regional Australia. Wastewater treatment in regional Australia faces challenges of odour control, poor pollutant and pathogen removal, and greenhouse gas emissions. This project aims to innovatively use iron salts to realise highly efficient wastewater treatment in regional areas. With Partner, Western Australia Water Corporation, this project expects to leverage a recent breakthrough discovery on iron chemistry to co-develop and field test a solar system that ....Transforming wastewater services in regional Australia. Wastewater treatment in regional Australia faces challenges of odour control, poor pollutant and pathogen removal, and greenhouse gas emissions. This project aims to innovatively use iron salts to realise highly efficient wastewater treatment in regional areas. With Partner, Western Australia Water Corporation, this project expects to leverage a recent breakthrough discovery on iron chemistry to co-develop and field test a solar system that doses wastewater with iron, to overcome four challenges and a supply chain issue simultaneously. Expected outcomes include industry capacity to adopt and commercialise a novel technology with important global relevance. Outcomes should reduce the inequity of wastewater services in regional Australia.Read moreRead less
Climate and environmental history of SE Queensland dunefields. This project aims to generate fundamental information about the timing and mode of formation of sand dunes in the world's largest downdrift sand system, Cooloola and Fraser Island, Queensland. The project aims to provide a world class record of climate variability, sea-level change and long term climate change from the sub-tropics of Australia, an area critical to understanding global climate links and sea-level change but where high ....Climate and environmental history of SE Queensland dunefields. This project aims to generate fundamental information about the timing and mode of formation of sand dunes in the world's largest downdrift sand system, Cooloola and Fraser Island, Queensland. The project aims to provide a world class record of climate variability, sea-level change and long term climate change from the sub-tropics of Australia, an area critical to understanding global climate links and sea-level change but where high quality long-term records are sparse and little investigated. This project will also underpin the outstanding universal value of the Fraser Island World Heritage Area which is based on the area being the world's largest sand island, but for which scientific understanding of the sand dunes is remarkably poor.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100192
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
Deep Protein Sequencing, Structure and Quantification Facility. This project aims to establish state-of-the-art complementary mass spectrometers to help research into molecular structure and interactions, post-translational modifications, compound stability and availability within complex biological samples. The facility’s complementary mass spectrometers combine high specificity with high sensitivity and ultrafast scanning, and are expected to rapidly discover, identify and characterise biomole ....Deep Protein Sequencing, Structure and Quantification Facility. This project aims to establish state-of-the-art complementary mass spectrometers to help research into molecular structure and interactions, post-translational modifications, compound stability and availability within complex biological samples. The facility’s complementary mass spectrometers combine high specificity with high sensitivity and ultrafast scanning, and are expected to rapidly discover, identify and characterise biomolecules including peptides, proteins and small molecules. The discovery of unknown compounds is expected to improve fundamental understanding of molecular structure and function, provide opportunities for new bio-industries in health and the environment, and generate commercial opportunities through spin-off companies, patents and licensing.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100121
Funder
Australian Research Council
Funding Amount
$670,000.00
Summary
A facility for the nanoscale imaging and characterisation of materials. Nanotechnology is dependent on measuring surface properties and this cutting-edge scanning probe microscopy facility will provide this capability. Atomic resolution imaging, along with spectroscopy for chemical information, and nanoindentation for physical information, will generate solutions for physical and life sciences, and materials engineering.
Forecasting fish resilience to environmental change in northern Australia. This project aims to use a traits-based modelling framework, incorporating variability both within and between species, to forecast the resilience of freshwater fishes in northern Australia to impending environmental change. While northern Australian rivers are among the most pristine and productive on earth, they face profound change due to human activity. Emerging evidence suggests that flexibility in functional traits ....Forecasting fish resilience to environmental change in northern Australia. This project aims to use a traits-based modelling framework, incorporating variability both within and between species, to forecast the resilience of freshwater fishes in northern Australia to impending environmental change. While northern Australian rivers are among the most pristine and productive on earth, they face profound change due to human activity. Emerging evidence suggests that flexibility in functional traits (e.g. life history, physiology, behaviour, diet) may result in resilience to environmental change. This project aims to provide decision-makers with essential information and new tools to underpin future planning and resource management.Read moreRead less