Structurally Nanoengineered Antimicrobial Polypeptide Particles (SNAPPs). This project aims to develop a new platform technology for the development of antimicrobial agents by combining expertise in polymer science and antimicrobial studies. It aims to develop new nanoengineered particles for combating antibiotic-resistant bacteria, investigate the influence of particle architecture on antibacterial properties, and determine the mechanism of action. This may support the development of antibiotic ....Structurally Nanoengineered Antimicrobial Polypeptide Particles (SNAPPs). This project aims to develop a new platform technology for the development of antimicrobial agents by combining expertise in polymer science and antimicrobial studies. It aims to develop new nanoengineered particles for combating antibiotic-resistant bacteria, investigate the influence of particle architecture on antibacterial properties, and determine the mechanism of action. This may support the development of antibiotic treatments using new polypeptide particles as antibacterial drugs, resulting in advances in nanobiotechnology, polymer therapeutics and advanced materials. The outcomes may revolutionise the synthetic approach to antimicrobial peptides and contribute significantly towards current antibiotic treatments and approaches for advanced antibacterial formulations.Read moreRead less
Engineering drug transportation behaviour in polymeric gel systems. In collaboration with Seagull Technologies, this project aims to engineer, study and mathematically model ultrasound-assisted biomacromolecule transport behaviour within polymeric gel systems, which may be useful in new drug delivery methods. The intended outcome is a novel set of polymeric gel systems, which can reversibly bind a wide variety of drugs (small molecules, nucleic acid based drugs, proteins), in which drug release ....Engineering drug transportation behaviour in polymeric gel systems. In collaboration with Seagull Technologies, this project aims to engineer, study and mathematically model ultrasound-assisted biomacromolecule transport behaviour within polymeric gel systems, which may be useful in new drug delivery methods. The intended outcome is a novel set of polymeric gel systems, which can reversibly bind a wide variety of drugs (small molecules, nucleic acid based drugs, proteins), in which drug release is triggered by an electric potential and drug transport is controlled by means of sonophoresis. The main advantage of drug delivery via sonophoresis is elimination of risks associated with injections such as infection and damage to local tissue, and elimination of patient discomfort, pain and fear.Read moreRead less
Cell facilitated controlled radical polymerisation. This project aims to develop a controlled polymerisation method by combining reversible addition fragmentation chain (RAFT) polymerisation technology and the redox processes within bacterial cells. This polymerisation method will copy biological information in the bacterial cell surface into a growing polymer structure. Variations in the monomer structures and functionality will be used to control the incorporation of cell surface chemistry int ....Cell facilitated controlled radical polymerisation. This project aims to develop a controlled polymerisation method by combining reversible addition fragmentation chain (RAFT) polymerisation technology and the redox processes within bacterial cells. This polymerisation method will copy biological information in the bacterial cell surface into a growing polymer structure. Variations in the monomer structures and functionality will be used to control the incorporation of cell surface chemistry into the new polymer structure. Such cell-enabled controlled polymerisation could advance polymer synthesis resulting in biologically instructed polymer-mimics and new antibacterial agents.Read moreRead less
ARC Centre of Excellence for Electromaterials Science. The ARC Centre of Excellence for Electromaterials Science (ACES) will create next generation electrochemical devices via the precision assembly of nano/micro dimensional components into macroscopic structures. Through the discovery of new materials and structures, and understanding how spatial arrangement in 3D influences chemical, physical and biological properties, ACES will define the cutting edge of Electromaterials Science. The resultin ....ARC Centre of Excellence for Electromaterials Science. The ARC Centre of Excellence for Electromaterials Science (ACES) will create next generation electrochemical devices via the precision assembly of nano/micro dimensional components into macroscopic structures. Through the discovery of new materials and structures, and understanding how spatial arrangement in 3D influences chemical, physical and biological properties, ACES will define the cutting edge of Electromaterials Science. The resulting technology breakthroughs will have a direct impact on some of today's most challenging global problems in clean energy, synthetic biosystems, diagnostics and soft robotics. National benefit to Australia will be realised through the creation of new manufacturing industries.Read moreRead less
Engineered ion channels for selective and switchable ion conduction. This project aims to develop an innovative bioinspired approach for fabricating angstrom-sized ion-channel membranes with specific ion selectivity, high ion conductivity and efficient gating function comparable to biological ion channels. Engineering of artificial channels with ion-channel-like shapes, ion selectivity filters and functional gates is expected to bring high-efficiency technologies to applications such as membrane ....Engineered ion channels for selective and switchable ion conduction. This project aims to develop an innovative bioinspired approach for fabricating angstrom-sized ion-channel membranes with specific ion selectivity, high ion conductivity and efficient gating function comparable to biological ion channels. Engineering of artificial channels with ion-channel-like shapes, ion selectivity filters and functional gates is expected to bring high-efficiency technologies to applications such as membrane separation and energy conversion. This project has potential to result in new knowledge of biomimetic design of artificial ion-channel membranes and directly benefit manufacturing industry for Australia.Read moreRead less