Functional polymeric nanopores from cyclic peptide templates. This research programme will develop nanotubes prepared through the self-assembly of cyclic peptide/polymer conjugates into functional devices for applications as nanopores. The project will establish the fundamental knowledge required to develop these materials into nanoporous polymeric films and transmembrane channels. The research programme will establish new synthetic routes to the conjugates, ascertain the technique of assembly i ....Functional polymeric nanopores from cyclic peptide templates. This research programme will develop nanotubes prepared through the self-assembly of cyclic peptide/polymer conjugates into functional devices for applications as nanopores. The project will establish the fundamental knowledge required to develop these materials into nanoporous polymeric films and transmembrane channels. The research programme will establish new synthetic routes to the conjugates, ascertain the technique of assembly into nanotubes, with a particular focus on improving the precision with which we achieve structural control, and explore the use of the nanotubes to design nanopores, for applications in the manufacture of nanoporous materials, as antibiotic agents and as biosensors.Read moreRead less
Study the Utility of Novel Drug Polymer Conjugates. The products likely to arise from the technology described in this proposal could have application in medical, veterinary and agricultural industries. It offers the potential to treat diseases that are at present poorly treated by enabling delivery direct to the diseased organ (e.g. eye - bacterial endophthalmitis). Completion of the project will also assist a fledgling biotech company transition to a development company with a multiple produ ....Study the Utility of Novel Drug Polymer Conjugates. The products likely to arise from the technology described in this proposal could have application in medical, veterinary and agricultural industries. It offers the potential to treat diseases that are at present poorly treated by enabling delivery direct to the diseased organ (e.g. eye - bacterial endophthalmitis). Completion of the project will also assist a fledgling biotech company transition to a development company with a multiple product portfolio, which will have a direct economic benefit to Australia both in terms of potential export earnings and as an employer highly skilled staff. The project will also provide research training and career opportunities for developing Australian based researchers.Read moreRead less
Multiblock copolymer synthesis for nano-engineered materials. This project aims to develop methodology for environmentally friendly and industrially applicable synthesis of new types of advanced polymeric materials comprising multiblock copolymers. Polymeric materials play an important role in society with applications from bulk plastics to advanced technological applications. This would enable the creation of advanced materials with specific engineering targets and applications ranging from nan ....Multiblock copolymer synthesis for nano-engineered materials. This project aims to develop methodology for environmentally friendly and industrially applicable synthesis of new types of advanced polymeric materials comprising multiblock copolymers. Polymeric materials play an important role in society with applications from bulk plastics to advanced technological applications. This would enable the creation of advanced materials with specific engineering targets and applications ranging from nanomedicine to materials science.Read moreRead less
New generation functional materials for 21st century applications: exploiting the properties of naphthalene diimides. This project melds the expertise of several research groups in the area of fluorescent material development. Based on a family of highly fluorescent molecules, the project will focus on designing new sensors, polymeric materials and molecular switching devices.
Radio-magnetic nanoparticles as bimodal positron emission tomography/magnetic resonance imaging contrast agents for dendritic cell tracking. Biomedical imaging is limited by a lack of commercial dual-mode contrast agents, which may be simultaneously used for magnetic resonance (MR) and positron emission tomography (PET) imaging. This project will develop a nanotechnology-based biocompatible dual-mode contrast agent for simultaneous PET and MR imaging, reducing associated side effects.
Nanoparticles to combat cellular dysfunction. This project aims to design, synthesise and characterise nanoparticles that can mediate the adverse effects of reactive oxygen species. The project expects to develop nanoparticles with tailored chemical functionality to modulate the concentration of reactive oxygen species and develop a platform technology for addressing conditions where reactive species are overproduced. The project will research how nanoparticles’ physicochemical properties affect ....Nanoparticles to combat cellular dysfunction. This project aims to design, synthesise and characterise nanoparticles that can mediate the adverse effects of reactive oxygen species. The project expects to develop nanoparticles with tailored chemical functionality to modulate the concentration of reactive oxygen species and develop a platform technology for addressing conditions where reactive species are overproduced. The project will research how nanoparticles’ physicochemical properties affect their activity, and how they affect cellular function, tissue morphology and particle transport in a biological milieu. The project is expected to benefit the advanced manufacturing, veterinary and medical sectors and could lead to new chemotherapeutics.Read moreRead less
Efficient ionic liquid-based reduction of nitrogen to ammonia. This project aims to develop a hybrid ionic liquid-nanostructured electrode platform to electrochemically convert nitrogen gas to ammonia. Ammonia production, mostly for fertilisers, consumes more than 1% of the global energy supply and contributes 1.6 % of global carbon dioxide emissions. A process that could convert nitrogen to ammonia using renewable energy would be an important alternative approach. This project will develop a pl ....Efficient ionic liquid-based reduction of nitrogen to ammonia. This project aims to develop a hybrid ionic liquid-nanostructured electrode platform to electrochemically convert nitrogen gas to ammonia. Ammonia production, mostly for fertilisers, consumes more than 1% of the global energy supply and contributes 1.6 % of global carbon dioxide emissions. A process that could convert nitrogen to ammonia using renewable energy would be an important alternative approach. This project will develop a platform for electrochemical conversion of nitrogen gas to ammonia and optimise it for use with surplus renewable energy supplies. The project is expected to contribute to mitigation of greenhouse emissions and create a technology for distributed production of ammonia and ammonium fertilisers.Read moreRead less
Functionalised nanomaterials for application as multimodal cancer imaging agents. Nanomaterials offer exciting opportunities for emerging diagnostic applications targeted to specific diseases. In this project, cutting-edge fundamental scientific developments will be pursued that will advance the application of nanomaterials in the diagnosis of cancer, a disease that accounts for over 40,000 deaths in Australia annually.
Advanced bio-inspired polymer assembly: tools for diagnostics, imaging and therapies. ‘Smart’ polymeric materials have the potential to make a significant impact in areas such as healthcare. However, to do this effectively the materials will need to respond intelligently to biological signals. This project will involve the synthesis and application of ‘smart’ polymer films and particles, which mimic biological behaviour.