Preparation and properties of oligo- and polycyclophanes. Materials with advanced optical and electronic properties. This project aims to prepare a novel class of organic and organometallic material that has both theoretical and practical applications. Nanotechnology requires unique arrangements of atoms that can give rise to enhanced macroscopic properties and we have embarked on a project that will provide new oligomers and polymers for the construction of the next generation of optical and el ....Preparation and properties of oligo- and polycyclophanes. Materials with advanced optical and electronic properties. This project aims to prepare a novel class of organic and organometallic material that has both theoretical and practical applications. Nanotechnology requires unique arrangements of atoms that can give rise to enhanced macroscopic properties and we have embarked on a project that will provide new oligomers and polymers for the construction of the next generation of optical and electronic devices.Read moreRead less
Surface engineering of oriented nano-layers for performance control. This research project will deliver knowledge on how to graft oriented, self assembled films from a surface, develop structure-property relationships at a nano-scale, develop a means to control these properties and develop characterization techniques at nano-scales. This research project, if successful, will deliver the ability to tailor the properties of a surface in a manner and over a range of properties that is not even cont ....Surface engineering of oriented nano-layers for performance control. This research project will deliver knowledge on how to graft oriented, self assembled films from a surface, develop structure-property relationships at a nano-scale, develop a means to control these properties and develop characterization techniques at nano-scales. This research project, if successful, will deliver the ability to tailor the properties of a surface in a manner and over a range of properties that is not even contemplated today.
In addition to the scientific benefits, there are also immediate commercial applications in Australia and worldwide for ophthalmic products (e.g. anti-fog and easy to clean lenses), if the balance of properties can be obtained.
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Conformationally constrained and immobilized beta-peptides. The research builds on world-class expertise in Australia (particularly Adelaide) in proteomics to provide a basis for fundamental advances in chemistry that will underpin the development of new pharmaceuticals and smart materials, and future technologies and industries. We create a mix of research at the interface of disciplines within academia and industry, with linkages to the very best international researchers and centres. A new cr ....Conformationally constrained and immobilized beta-peptides. The research builds on world-class expertise in Australia (particularly Adelaide) in proteomics to provide a basis for fundamental advances in chemistry that will underpin the development of new pharmaceuticals and smart materials, and future technologies and industries. We create a mix of research at the interface of disciplines within academia and industry, with linkages to the very best international researchers and centres. A new critical mass of expertise in a number of advancing areas of chemistry, biology, and materials science will be introduced to Australia. This will enhance existing strengths and opportunities in proteomics and biomedical research for the treatment of disease.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668374
Funder
Australian Research Council
Funding Amount
$470,000.00
Summary
State-of-the-art NMR Facilities. This proposal will significantly enhance the NMR research capability and capacities at UoW and ANU. These schools have internationally recognised strengths in fundamentals of synthetic organic chemistry, therapeutic drug design and synthesis, protein chemistry and structural biology. This equipment will enhance the productivity of these researchers, increase their collaborative and scientific outputs and allow for training of students in the latest technologies ....State-of-the-art NMR Facilities. This proposal will significantly enhance the NMR research capability and capacities at UoW and ANU. These schools have internationally recognised strengths in fundamentals of synthetic organic chemistry, therapeutic drug design and synthesis, protein chemistry and structural biology. This equipment will enhance the productivity of these researchers, increase their collaborative and scientific outputs and allow for training of students in the latest technologies and importantly, contribute to Australia's development as a knowledge-based economy.Read moreRead less
New clean and green aqueous metathesis. The technique of olefin metathesis has already yielded new pharmaceuticals and materials for use in consumer products and ballistic protection. This project will help move metathesis into the realms of natures aqueous environment, a key advance if metathesis is to reveal its full potential in biological, polymeric, and pharmaceutical applications. We specifically aim to target treatments for cataract (and other conditions associated with an aging populatio ....New clean and green aqueous metathesis. The technique of olefin metathesis has already yielded new pharmaceuticals and materials for use in consumer products and ballistic protection. This project will help move metathesis into the realms of natures aqueous environment, a key advance if metathesis is to reveal its full potential in biological, polymeric, and pharmaceutical applications. We specifically aim to target treatments for cataract (and other conditions associated with an aging population) and also important new biopolymers for use in health technologies of the future.Read moreRead less
Electron transfer in proteins, a study of mechanism and function. Our research will probe the mechanisms by which nature's living systems build, maintain, and reproduce. We present an ability to understand these processes at a detailed molecular level using science and technology at the forefront of multidisciplinary research. The research will provide a foundation for new smart materials, technologies and future industries, and also ways forward for future basic scientific research and endeavo ....Electron transfer in proteins, a study of mechanism and function. Our research will probe the mechanisms by which nature's living systems build, maintain, and reproduce. We present an ability to understand these processes at a detailed molecular level using science and technology at the forefront of multidisciplinary research. The research will provide a foundation for new smart materials, technologies and future industries, and also ways forward for future basic scientific research and endeavor. All this is done with the best international researchers and capabilities within a local environment that will help to train the next generation of Australian scientists.Read moreRead less
Mimicking peptide structure - towards an aqueous environment. In this proposal we develop a fundamental understanding of the balance between 'weak' and 'strong' forces to define the properties of peptides and proteins. This will allow the design of new biological probes and materials with tailor-made chemical and physical properties for use in bioengineering, biotechnology, proteomics, and drug design. One such example is the design and preparation of a new chemical agent for the non-surgical tr ....Mimicking peptide structure - towards an aqueous environment. In this proposal we develop a fundamental understanding of the balance between 'weak' and 'strong' forces to define the properties of peptides and proteins. This will allow the design of new biological probes and materials with tailor-made chemical and physical properties for use in bioengineering, biotechnology, proteomics, and drug design. One such example is the design and preparation of a new chemical agent for the non-surgical treatment for cataract, the major cause of blindness world-wide.Read moreRead less
Interfacial Studies of Nanoparticulate Dendrimers for Improved BioPharmaceutical Application. Dendrimers are a novel class of nanoparticles with exciting potential as pharmaceuticals for the prevention of major disease states, e.g. viral and cancer. A colloid and interfacial chemistry approach will be employed to develop an understanding of the mechanisms for the solution to cell transport processes and for optimisation of formulation strategies for delivery vehicles. Significant advances in t ....Interfacial Studies of Nanoparticulate Dendrimers for Improved BioPharmaceutical Application. Dendrimers are a novel class of nanoparticles with exciting potential as pharmaceuticals for the prevention of major disease states, e.g. viral and cancer. A colloid and interfacial chemistry approach will be employed to develop an understanding of the mechanisms for the solution to cell transport processes and for optimisation of formulation strategies for delivery vehicles. Significant advances in the development of novel pharmaceutical products will result, with significant social and economic benefits nationally and internationally.Read moreRead less
Understanding the mechanism of two important cytochrome P450 catalysed reactions: dehydrogenation and C-C cleavage. Cytochromes P450 are enzymes that play key roles in drug metabolism and biosynthesis. P450s often catalyse hydroxylation but also carry out important transformations such as dehydrogenation or carbon-carbon bond cleavage. Such reactions are pivotal in many biological pathways. This work will elucidate the mechanism of these transformations and the factors that facilitate their occu ....Understanding the mechanism of two important cytochrome P450 catalysed reactions: dehydrogenation and C-C cleavage. Cytochromes P450 are enzymes that play key roles in drug metabolism and biosynthesis. P450s often catalyse hydroxylation but also carry out important transformations such as dehydrogenation or carbon-carbon bond cleavage. Such reactions are pivotal in many biological pathways. This work will elucidate the mechanism of these transformations and the factors that facilitate their occurrence. This will mainly entail the synthesis of small organic mechanistic probes and determining the structure and stereochemistry of the product of enzymic oxidation. Understanding these mechanisms will allow us to predict when such reactions will occur, enabling their utilisation in for example drug design in the avoidance of the formation of toxic metabolites.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100168
Funder
Australian Research Council
Funding Amount
$1,235,000.00
Summary
Adelaide Nuclear Magnetic Resonance (NMR). Nuclear Magnetic Resonance (NMR) spectroscopy is a fundamental underpinning technology for the advancement of the many sciences which require determination of the structure of molecules. This project will significantly enhance and broaden NMR capabilities in South Australia and advance world-class research in chemistry, materials science, nanotechnology and biochemistry.