Synthesis of Bioactive Metabolites from Myxobacteria. The crocacins and apicularens are two diverse groups of biologically active molecules isolated from myxobacteria. Crocacins A-D are dipeptides which show antifungal activity and are highly cytostatic in mammalian cell cultures. The novel macrolide apicularen A is highly active against a number of human tumour cell lines and shows promise as a new type of anticancer compound. The aim of this project is develop a methodology to synthesise these ....Synthesis of Bioactive Metabolites from Myxobacteria. The crocacins and apicularens are two diverse groups of biologically active molecules isolated from myxobacteria. Crocacins A-D are dipeptides which show antifungal activity and are highly cytostatic in mammalian cell cultures. The novel macrolide apicularen A is highly active against a number of human tumour cell lines and shows promise as a new type of anticancer compound. The aim of this project is develop a methodology to synthesise these novel compounds.Read moreRead less
Improving predictions of species distribution dynamics. This project aims to mainstream methods for improved prediction of species distributions under the impacts of environmental change. This is important because these predictions are commonly used to guide environmental decisions, but the standard modelling methods used to produce them have critical limitations. This project intends to (i) make key statistical developments to methods for modelling dynamics of species distributions and (ii) tra ....Improving predictions of species distribution dynamics. This project aims to mainstream methods for improved prediction of species distributions under the impacts of environmental change. This is important because these predictions are commonly used to guide environmental decisions, but the standard modelling methods used to produce them have critical limitations. This project intends to (i) make key statistical developments to methods for modelling dynamics of species distributions and (ii) translate the methods into practice, through guidelines, tools and training, engagement with users and case studies addressing species of current concern. This should provide significant benefits because it will enable better decisions and more effective and cost-efficient management actions.Read moreRead less