Preparation and properties of oligo- and polycyclophanes. Materials with advanced optical and electronic properties. This project aims to prepare a novel class of organic and organometallic material that has both theoretical and practical applications. Nanotechnology requires unique arrangements of atoms that can give rise to enhanced macroscopic properties and we have embarked on a project that will provide new oligomers and polymers for the construction of the next generation of optical and el ....Preparation and properties of oligo- and polycyclophanes. Materials with advanced optical and electronic properties. This project aims to prepare a novel class of organic and organometallic material that has both theoretical and practical applications. Nanotechnology requires unique arrangements of atoms that can give rise to enhanced macroscopic properties and we have embarked on a project that will provide new oligomers and polymers for the construction of the next generation of optical and electronic devices.Read moreRead less
Conformationally constrained and immobilized beta-peptides. The research builds on world-class expertise in Australia (particularly Adelaide) in proteomics to provide a basis for fundamental advances in chemistry that will underpin the development of new pharmaceuticals and smart materials, and future technologies and industries. We create a mix of research at the interface of disciplines within academia and industry, with linkages to the very best international researchers and centres. A new cr ....Conformationally constrained and immobilized beta-peptides. The research builds on world-class expertise in Australia (particularly Adelaide) in proteomics to provide a basis for fundamental advances in chemistry that will underpin the development of new pharmaceuticals and smart materials, and future technologies and industries. We create a mix of research at the interface of disciplines within academia and industry, with linkages to the very best international researchers and centres. A new critical mass of expertise in a number of advancing areas of chemistry, biology, and materials science will be introduced to Australia. This will enhance existing strengths and opportunities in proteomics and biomedical research for the treatment of disease.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668374
Funder
Australian Research Council
Funding Amount
$470,000.00
Summary
State-of-the-art NMR Facilities. This proposal will significantly enhance the NMR research capability and capacities at UoW and ANU. These schools have internationally recognised strengths in fundamentals of synthetic organic chemistry, therapeutic drug design and synthesis, protein chemistry and structural biology. This equipment will enhance the productivity of these researchers, increase their collaborative and scientific outputs and allow for training of students in the latest technologies ....State-of-the-art NMR Facilities. This proposal will significantly enhance the NMR research capability and capacities at UoW and ANU. These schools have internationally recognised strengths in fundamentals of synthetic organic chemistry, therapeutic drug design and synthesis, protein chemistry and structural biology. This equipment will enhance the productivity of these researchers, increase their collaborative and scientific outputs and allow for training of students in the latest technologies and importantly, contribute to Australia's development as a knowledge-based economy.Read moreRead less
New clean and green aqueous metathesis. The technique of olefin metathesis has already yielded new pharmaceuticals and materials for use in consumer products and ballistic protection. This project will help move metathesis into the realms of natures aqueous environment, a key advance if metathesis is to reveal its full potential in biological, polymeric, and pharmaceutical applications. We specifically aim to target treatments for cataract (and other conditions associated with an aging populatio ....New clean and green aqueous metathesis. The technique of olefin metathesis has already yielded new pharmaceuticals and materials for use in consumer products and ballistic protection. This project will help move metathesis into the realms of natures aqueous environment, a key advance if metathesis is to reveal its full potential in biological, polymeric, and pharmaceutical applications. We specifically aim to target treatments for cataract (and other conditions associated with an aging population) and also important new biopolymers for use in health technologies of the future.Read moreRead less
Electron transfer in proteins, a study of mechanism and function. Our research will probe the mechanisms by which nature's living systems build, maintain, and reproduce. We present an ability to understand these processes at a detailed molecular level using science and technology at the forefront of multidisciplinary research. The research will provide a foundation for new smart materials, technologies and future industries, and also ways forward for future basic scientific research and endeavo ....Electron transfer in proteins, a study of mechanism and function. Our research will probe the mechanisms by which nature's living systems build, maintain, and reproduce. We present an ability to understand these processes at a detailed molecular level using science and technology at the forefront of multidisciplinary research. The research will provide a foundation for new smart materials, technologies and future industries, and also ways forward for future basic scientific research and endeavor. All this is done with the best international researchers and capabilities within a local environment that will help to train the next generation of Australian scientists.Read moreRead less
Mimicking peptide structure - towards an aqueous environment. In this proposal we develop a fundamental understanding of the balance between 'weak' and 'strong' forces to define the properties of peptides and proteins. This will allow the design of new biological probes and materials with tailor-made chemical and physical properties for use in bioengineering, biotechnology, proteomics, and drug design. One such example is the design and preparation of a new chemical agent for the non-surgical tr ....Mimicking peptide structure - towards an aqueous environment. In this proposal we develop a fundamental understanding of the balance between 'weak' and 'strong' forces to define the properties of peptides and proteins. This will allow the design of new biological probes and materials with tailor-made chemical and physical properties for use in bioengineering, biotechnology, proteomics, and drug design. One such example is the design and preparation of a new chemical agent for the non-surgical treatment for cataract, the major cause of blindness world-wide.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453743
Funder
Australian Research Council
Funding Amount
$237,654.00
Summary
Advanced Materials Laser Characterisation Facility. A networked laser facility spanning the University of Melbourne, Monash University, the University of Adelaide, and Flinders University, will be created by integrating new laser instrumentation with existing specialised infrastructure. The facility will provide chemists at the four institutions with the necessary equipment to collaboratively investigate and optimise the properties of a diverse array of advanced materials, including nanoparticle ....Advanced Materials Laser Characterisation Facility. A networked laser facility spanning the University of Melbourne, Monash University, the University of Adelaide, and Flinders University, will be created by integrating new laser instrumentation with existing specialised infrastructure. The facility will provide chemists at the four institutions with the necessary equipment to collaboratively investigate and optimise the properties of a diverse array of advanced materials, including nanoparticles, polymers, biomaterials, and artificial photosynthetic systems. The outcome will be a world-class research network, outfitted with a suite of sophisticated techniques that are not currently available at any single university, or through any other Australian institution or consortium.Read moreRead less
New Methodology for the Stereoselective Construction of Oxygen Heterocycles and Rare Sugar Analogues. The overall goal of this research is to develop new synthetic methods, particularly ones that exhibit high levels of stereocontrol. Current research efforts are directed towards the stereoselective construction of oxygen heterocycles and rare sugar analogues both in their racemic and chiral forms utilising 1,2-dioxines containing tethered hydroxyl moieties as the key chemical precursors. It is e ....New Methodology for the Stereoselective Construction of Oxygen Heterocycles and Rare Sugar Analogues. The overall goal of this research is to develop new synthetic methods, particularly ones that exhibit high levels of stereocontrol. Current research efforts are directed towards the stereoselective construction of oxygen heterocycles and rare sugar analogues both in their racemic and chiral forms utilising 1,2-dioxines containing tethered hydroxyl moieties as the key chemical precursors. It is envisaged that these investigations will lead to the development of simple experimental protocols for the synthesis of new bioactive organics.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989336
Funder
Australian Research Council
Funding Amount
$560,000.00
Summary
The South Australian Facility for Small and Large Molecule X-Ray Diffraction Structure Determination. The precise three dimensional arrangement of atoms within molecular and macromolecular structures defines their function. Thus, the discovery, development and application of biological compounds, catalysts, nanodevices and pharmaceuticals require X-ray diffraction structure determination. These endeavours underpin the conversion of academic research into real benefits for the community and are ....The South Australian Facility for Small and Large Molecule X-Ray Diffraction Structure Determination. The precise three dimensional arrangement of atoms within molecular and macromolecular structures defines their function. Thus, the discovery, development and application of biological compounds, catalysts, nanodevices and pharmaceuticals require X-ray diffraction structure determination. These endeavours underpin the conversion of academic research into real benefits for the community and are critical for the competitiveness of Australian industry, national productivity and economic growth. This application seeks to provide a facility for multidisciplinary scientific development that will enhance academic-industrial collaboration. This will position SA research community for scientific breakthroughs that benefit the Australian community.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347746
Funder
Australian Research Council
Funding Amount
$199,000.00
Summary
Circular-dichroism stopped-flow spectrometer for rapid molecular interactions and membrane transport. A stopped-flow spectroscope is requested that can capture the rapid kinetics of changes in conformation of biopolymers, macromolecules and chiral catalysts as they interact with other molecules. This includes measurement of rapid transport of solutes through membrane proteins in lipid membranes. The versatile instrument can also determine circular dichroism spectra of peptides, proteins, tannins ....Circular-dichroism stopped-flow spectrometer for rapid molecular interactions and membrane transport. A stopped-flow spectroscope is requested that can capture the rapid kinetics of changes in conformation of biopolymers, macromolecules and chiral catalysts as they interact with other molecules. This includes measurement of rapid transport of solutes through membrane proteins in lipid membranes. The versatile instrument can also determine circular dichroism spectra of peptides, proteins, tannins, pigment complexes and chiral catalysts that is required within several existing collaborations to understand the tertiary structures, stability and interactions between the complex molecules. The instrument will significantly strengthen research on macromolecules and polymers that have applications in the wine industry, nanotechnology, and biotechnology.Read moreRead less