The recirculation of myeloid dendritic cells. This project aims to understand dendritic cell recirculation. It will use virological tools to track dendritic cell migration, and identify key decision points. Expected outcomes include enhanced capacity in basic research and greater interdisciplinary collaboration between virology and immunology research groups. Significant benefits will include a new understanding of how G protein coupled receptor signalling and other tissue cues guide dendritic c ....The recirculation of myeloid dendritic cells. This project aims to understand dendritic cell recirculation. It will use virological tools to track dendritic cell migration, and identify key decision points. Expected outcomes include enhanced capacity in basic research and greater interdisciplinary collaboration between virology and immunology research groups. Significant benefits will include a new understanding of how G protein coupled receptor signalling and other tissue cues guide dendritic cell recirculation, and what consequences the recirculation has for immune cell function. This understanding will significantly advance our basic understanding of the immune system.Read moreRead less
Computational systems biology: understanding mammalian cell fates using genome-scale network models. Mutations can disrupt the cellular networks that control normal development, causing cells to develop abnormally including in ways that lead to cancer. The project will analyse genome sequences from more than 700 pancreatic cancers and matched controls to precisely map the causative trail from mutations to disrupted networks to altered cell development.
Towards high efficiency biofuel systems: a molecular resolution three-dimensional atlas of the photosynthetic machinery of a high-efficiency green algae cell. Solar-powered single-cell green-algae systems represent a powerful and environmentally friendly biotechnology used to produce clean fuels, food and high value products. This project is focused on solving the three-dimensional structure of key components of the photosynthetic machinery to improve the efficiency and profitability of advance ....Towards high efficiency biofuel systems: a molecular resolution three-dimensional atlas of the photosynthetic machinery of a high-efficiency green algae cell. Solar-powered single-cell green-algae systems represent a powerful and environmentally friendly biotechnology used to produce clean fuels, food and high value products. This project is focused on solving the three-dimensional structure of key components of the photosynthetic machinery to improve the efficiency and profitability of advance microalgae production systems.Read moreRead less
Bioengineering High Efficiency Solar Driven H2 Production. The project aims to bio-engineer high-efficiency microalgae cell-lines that can drive solar powered H2 production from water. It plans to do so by increasing proton and electron supply to the H2-producing hydrogenase. It builds on patented cell lines that have enhanced light capture efficiency and H2 production capabilities. The aim of this project is to increase the efficiency of the last stage of the process (three fold) in a major ste ....Bioengineering High Efficiency Solar Driven H2 Production. The project aims to bio-engineer high-efficiency microalgae cell-lines that can drive solar powered H2 production from water. It plans to do so by increasing proton and electron supply to the H2-producing hydrogenase. It builds on patented cell lines that have enhanced light capture efficiency and H2 production capabilities. The aim of this project is to increase the efficiency of the last stage of the process (three fold) in a major step in developing economic solar-fuel systems. National benefits include the development of advanced microalgae fuels systems to increase future fuel security, reduce CO2 emissions and assist with regional development.Read moreRead less
Gain from pain: new tools from venomous animals for exploring pain pathways. This project aims to explore animal venoms for new pain-causing toxins, to determine their structure and mechanism of action. Many venomous animals use their venom defensively and envenomation is frequently associated with rapid and often excruciating pain. In most cases the molecular mechanisms by which they achieve this is unknown. Using biochemical, pharmacological and biophysical techniques, this project expects to ....Gain from pain: new tools from venomous animals for exploring pain pathways. This project aims to explore animal venoms for new pain-causing toxins, to determine their structure and mechanism of action. Many venomous animals use their venom defensively and envenomation is frequently associated with rapid and often excruciating pain. In most cases the molecular mechanisms by which they achieve this is unknown. Using biochemical, pharmacological and biophysical techniques, this project expects to uncover toxins that employ new mechanisms of pain signalling, leading to new insights into pain physiology.Read moreRead less
Advanced solar powered hydrogen production systems based on green algal cells. This project aims to enhance the efficiency of solar powered hydrogen production from water and will facilitate the co-production of H2 and oil through microalgal biofuel systems. This frontier science project will therefore deliver a process with high solar conversion efficiency and will deliver multiple product streams increasing profitability.
Quiet sleep is for repair, active sleep is for learning. Sleep is thought to achieve many different functions, from brain waste clearance to regulating emotions and perception. Understanding sleep functions in animal models has been difficult because sleep has been typically reduced to a single state. Our discovery of distinct sleep stages in the fruit fly provides a powerful way to study how different conserved sleep functions are regulated. This project will use new strategies for manipulating ....Quiet sleep is for repair, active sleep is for learning. Sleep is thought to achieve many different functions, from brain waste clearance to regulating emotions and perception. Understanding sleep functions in animal models has been difficult because sleep has been typically reduced to a single state. Our discovery of distinct sleep stages in the fruit fly provides a powerful way to study how different conserved sleep functions are regulated. This project will use new strategies for manipulating sleep stages in flies to understand their respective physiology and functions. We will test our hypothesis that different categories of sleep functions have been segregated by evolution into different stages: a quiet stage concerned primarily with brain repair and an active stage important for learning.
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Toward sustainable diesel production using microbial cells: unravelling isoprenoid pathway regulation through systems biology. The methylerythritol pyrophosphate (MEP) pathway for isoprenoid production is an essential biochemical pathway. It was only fully elucidated a decade ago, and the regulatory controls over this pathway are not understood. The objective of this project is to elucidate the mechanisms by which the MEP pathway is controlled in E. coli using a novel systems biology approach. U ....Toward sustainable diesel production using microbial cells: unravelling isoprenoid pathway regulation through systems biology. The methylerythritol pyrophosphate (MEP) pathway for isoprenoid production is an essential biochemical pathway. It was only fully elucidated a decade ago, and the regulatory controls over this pathway are not understood. The objective of this project is to elucidate the mechanisms by which the MEP pathway is controlled in E. coli using a novel systems biology approach. Understanding control of the MEP pathway is required to gain insight into homeostatic control of this essential pathway, and enable biotechnological engineering of E. coli in order to produce a wide range of industrially useful isoprenoids (including biofuels, pharmaceuticals, industrial chemicals, neutraceuticals, food additives, perfumes and many more).Read moreRead less
Mapping and defining inter-organ cross talk during exercise. This project aims to examine precisely how organs communicate and interact. These interactions are particularly important during exercise, when continued movement demands intricate organ communication, and have major ramifications for the whole organism as it ages. Precisely how this communication takes place is unclear, but we now know that the movement of cargo with extracellular vesicles (EVs) plays an integral role in organ to orga ....Mapping and defining inter-organ cross talk during exercise. This project aims to examine precisely how organs communicate and interact. These interactions are particularly important during exercise, when continued movement demands intricate organ communication, and have major ramifications for the whole organism as it ages. Precisely how this communication takes place is unclear, but we now know that the movement of cargo with extracellular vesicles (EVs) plays an integral role in organ to organ communication. This project expects to build upon unprecedented recent developments we have made in the biology of inter-organ communication via EVs. The expected outcomes will have broad impact across life science and biotechnology.Read moreRead less
Placental nutrient transport shows how complex traits evolve. This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The pr ....Placental nutrient transport shows how complex traits evolve. This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The project will provide fundamental advances in our knowledge of the nutrient transport during pregnancy that is required to produce a healthy baby.Read moreRead less