Design of the cardiovascular system of living and fossil vertebrates. This project aims to understand how the heart and blood vessels evolved in mammals, birds, reptiles and fish to achieve efficiency. The heart is the most important organ for life. The project will study the structure and function of vertebrate animals’ hollow and spongy hearts to show how energetics shaped their evolution. It will measure arterial holes in bone to gauge brain and bone metabolism, which opens up a new way to me ....Design of the cardiovascular system of living and fossil vertebrates. This project aims to understand how the heart and blood vessels evolved in mammals, birds, reptiles and fish to achieve efficiency. The heart is the most important organ for life. The project will study the structure and function of vertebrate animals’ hollow and spongy hearts to show how energetics shaped their evolution. It will measure arterial holes in bone to gauge brain and bone metabolism, which opens up a new way to measure metabolism in extinct animals directly from fossils, rather than by inference from living relatives. The expected outcome is to correlate cardiovascular design and metabolic rates of organs.Read moreRead less
Transcriptional regulation by microRNAs. This project aims to better understand microRNAs, which are of central importance to how genes are regulated. Despite recent data indicating microRNAs may also play more extensive and diverse roles as nuclear regulators of gene transcription, research has been restricted to their well known mechanism of action in the cytoplasm where they post transcriptionally silence genes. This project will investigate the potential for microRNAs to regulate transcripti ....Transcriptional regulation by microRNAs. This project aims to better understand microRNAs, which are of central importance to how genes are regulated. Despite recent data indicating microRNAs may also play more extensive and diverse roles as nuclear regulators of gene transcription, research has been restricted to their well known mechanism of action in the cytoplasm where they post transcriptionally silence genes. This project will investigate the potential for microRNAs to regulate transcription on a genome-wide scale and will thereby reveal the full extent of mechanisms by which these important genetic switches control gene expression networks the characteristics of cells. This is of fundamental significance to our understanding of gene regulation.Read moreRead less
Going with the flow: directing nutrient rich blood to the brain. This project aims to visualise and measure flow of blood from the umbilical cord to the fetal brain and to understand how delivery of oxygen and glucose to the brain is prioritised by constriction or relaxation of a specialised shunt, the ductus venosus. The project will directly and non-invasively measure this fundamental phenomenon with novel MRI protocols. Expected outcomes of this project include advances in measuring fetal blo ....Going with the flow: directing nutrient rich blood to the brain. This project aims to visualise and measure flow of blood from the umbilical cord to the fetal brain and to understand how delivery of oxygen and glucose to the brain is prioritised by constriction or relaxation of a specialised shunt, the ductus venosus. The project will directly and non-invasively measure this fundamental phenomenon with novel MRI protocols. Expected outcomes of this project include advances in measuring fetal blood flow and the exchange of expertise between leading researchers in Australia and Canada. In the long-term, this will enhance Australia’s research capacity in fetal physiology and may lead to new tools for monitoring or supporting fetal development.Read moreRead less
Opening and closing doors in the fetal circulation impacts brain metabolism. This project aims to measure blood flow from the umbilical cord through special shunts or doors to the fetal brain and to understand how changes in delivery of oxygen may impact fetal brain metabolism. This fundamental phenomenon will be measured with novel MRI protocols developed by a multidisciplinary, international team. Expected outcomes of this project include world-leading advances in measuring fetal blood flow ....Opening and closing doors in the fetal circulation impacts brain metabolism. This project aims to measure blood flow from the umbilical cord through special shunts or doors to the fetal brain and to understand how changes in delivery of oxygen may impact fetal brain metabolism. This fundamental phenomenon will be measured with novel MRI protocols developed by a multidisciplinary, international team. Expected outcomes of this project include world-leading advances in measuring fetal blood flow and brain metabolism with exchange of expertise between leading researchers in Australia and Canada and their trainees. In the long-term, this should provide significant benefits in enhancing Australia’s research capacity in fetal physiology and may lead to new tools for monitoring or supporting fetal development.Read moreRead less
The impact of strategic alignment on IT outsourcing success in a complex service setting. Improved conceptual and methodological understanding of strategic alignment is essential for better IT outsourcing decisions. This research will improve the performance of Australian industry by investigating how strategically well aligned ITO investments can lead to improved performance and greater competitive advantage.
A Platform for Rapid and Flexible Development of Context-Aware Web Services. Context awareness is one of the most exciting trends in computing today, and it holds the potential to make our daily life more productive, convenient and enjoyable. The proposed project will produce a comprehensive platform for developing context-aware Web services, which will facilitate ready implementation of many innovative applications and make important contributions to Australian society and the national economy. ....A Platform for Rapid and Flexible Development of Context-Aware Web Services. Context awareness is one of the most exciting trends in computing today, and it holds the potential to make our daily life more productive, convenient and enjoyable. The proposed project will produce a comprehensive platform for developing context-aware Web services, which will facilitate ready implementation of many innovative applications and make important contributions to Australian society and the national economy. One such application is an intelligent seniors assistance service that will improve quality of life for senior citizens while helping them maintain an independent lifestyle. This project will also place Australia at the forefront of Web service development.Read moreRead less
Normalizing XML Documents. Our work will be of great benefit, both to the research community and to the ICT industry. The project addresses one of the most important problems in XML usage and we expect our results to be published in important international forums, as has our preliminary research on the topic. This will significantly improve Australia's reputation in research in the ICT area. In the longer term, we intend to build commercial software tools based on the results of our research ....Normalizing XML Documents. Our work will be of great benefit, both to the research community and to the ICT industry. The project addresses one of the most important problems in XML usage and we expect our results to be published in important international forums, as has our preliminary research on the topic. This will significantly improve Australia's reputation in research in the ICT area. In the longer term, we intend to build commercial software tools based on the results of our research and this will be of direct benefit to the Australian economy and the Australian ICT industry.Read moreRead less
Integration of Object Behavior in Federated Information Systems. Integration of autonomous object-oriented systems requires the integration
of object structure and object behaviour. Research in federated information
systems has so far mainly addressed integration of object structure. This
project will investigate the integration of object behaviour, especially object
life cycles. A major application area is the integration of business processes,
which is typically required when companies me ....Integration of Object Behavior in Federated Information Systems. Integration of autonomous object-oriented systems requires the integration
of object structure and object behaviour. Research in federated information
systems has so far mainly addressed integration of object structure. This
project will investigate the integration of object behaviour, especially object
life cycles. A major application area is the integration of business processes,
which is typically required when companies merge or enter into
consumer-producer relationships and constitutes a key capability for B2B e-commerce
systems. Consistency criteria for behaviour integration
will be defined and applied in a graphical integration tool that guides the
definition of global behavioural views upon autonomous object-oriented systems.
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How SEP-like genes determine cereal inflorescence architecture. This project aims to understand the morphological diversity of inflorescence architecture between cereal crop species. To do so, this project will identify functions and analyse the regulatory networks of conserved SEPALLATA genes (SEPs). This will enable them to determine cereal inflorescence morphogenesis of rice (branching) and barley (non-branching), representing the most important cereals. Identifying and understanding rice and ....How SEP-like genes determine cereal inflorescence architecture. This project aims to understand the morphological diversity of inflorescence architecture between cereal crop species. To do so, this project will identify functions and analyse the regulatory networks of conserved SEPALLATA genes (SEPs). This will enable them to determine cereal inflorescence morphogenesis of rice (branching) and barley (non-branching), representing the most important cereals. Identifying and understanding rice and barley SEPs, their direct targets and interactors, and how they regulate inflorescence branches and spikelets in both species is expected to provide evolutionary and developmental insights and targets to improve for crop yield. A molecular understanding of the regulatory network that underpins inflorescence shape and grain number will advance fundamental biology, and could form the basis for significant yield improvements by manipulating key points in the developmental pathway.Read moreRead less
Multiscale Singularly Perturbed Control Systems. We propose to develop a unified averaging technique to analyse deterministic and stochastic multiscale singularly perturbed control systems. Such systems arise as mathematical models of real-world dynamical systems in which state variables can change their values with the rates of different orders of magnitude. The technique is based on the assumption that the system, which would describe the dynamics of the fast state variables if slow ones were ....Multiscale Singularly Perturbed Control Systems. We propose to develop a unified averaging technique to analyse deterministic and stochastic multiscale singularly perturbed control systems. Such systems arise as mathematical models of real-world dynamical systems in which state variables can change their values with the rates of different orders of magnitude. The technique is based on the assumption that the system, which would describe the dynamics of the fast state variables if slow ones were frozen, possesses certain ergodicity properties expressed in the existence of its limit occupational measures set. Conditions for the existence of such a set will be studied and its structure will be described.Read moreRead less