Metalloproteomics: A new piece of the systems biology puzzle. Systems biology uses advanced analytical technology to study the complex chemistry of the living cell. Many cellular functions are the result of chemical reactions involving metalloproteins, which are notoriously difficult to study due to the weak bonds between metal and protein that is not normally amenable to traditional proteomic approaches. In partnership with the leading analytical manufacturer Agilent Technologies, this project ....Metalloproteomics: A new piece of the systems biology puzzle. Systems biology uses advanced analytical technology to study the complex chemistry of the living cell. Many cellular functions are the result of chemical reactions involving metalloproteins, which are notoriously difficult to study due to the weak bonds between metal and protein that is not normally amenable to traditional proteomic approaches. In partnership with the leading analytical manufacturer Agilent Technologies, this project aims to adapt and apply advanced mass spectrometry to the study of metalloproteins, developing new methods for studying hundreds of molecules in single experiments. Using the C. elegans model organism the project aims to showcase the importance of metals in biology and develop new solutions for the $2.9 billion proteomics industry.Read moreRead less
Engineering cyanobacteria for high-value flavours and fragrances production. Engineering the metabolism of cyanobacteria for industrial production of flavours and fragrances has great commercial potential. Cyanobacteria capture more than 25% of the planet’s carbon. Due to their native metabolism and capacity to express complex plant proteins, they represent an attractive Synthetic Biology platform for the biosynthesis of flavours and fragrances. Combining physiological strain characterisation an ....Engineering cyanobacteria for high-value flavours and fragrances production. Engineering the metabolism of cyanobacteria for industrial production of flavours and fragrances has great commercial potential. Cyanobacteria capture more than 25% of the planet’s carbon. Due to their native metabolism and capacity to express complex plant proteins, they represent an attractive Synthetic Biology platform for the biosynthesis of flavours and fragrances. Combining physiological strain characterisation and ‘omics studies, new Synthetic Biology strategies and models will be developed. The project aims at engineering a suite of modified freshwater and marine cyanobacteria for flavours and fragrances biosynthesis. The project aims at enabling solar biomanufacturing to underpin the emergence of an advanced Australian bioeconomy.Read moreRead less
Nutritional and bacterial influences on gut and peripheral homeostasis. Nutritional and bacterial influences on gut and peripheral homeostasis. This project aims to understand the role of macronutrients on gut homeostasis. While the understanding of what factors affect gut homeostasis is still in its infancy, scientists know that its disruption contributes to a broad range of inflammatory diseases, including type 1 diabetes and asthma. This project will determine the role of specific macronutrie ....Nutritional and bacterial influences on gut and peripheral homeostasis. Nutritional and bacterial influences on gut and peripheral homeostasis. This project aims to understand the role of macronutrients on gut homeostasis. While the understanding of what factors affect gut homeostasis is still in its infancy, scientists know that its disruption contributes to a broad range of inflammatory diseases, including type 1 diabetes and asthma. This project will determine the role of specific macronutrients on gut microbiota, gut epithelium, and immunity in mice, and the receptors involved. This research could ultimately lead to significant decreases in the cost of healthcare.Read moreRead less
Preventing railway suicide: An open-systems perspective. Preventing railway suicide: An open-systems perspective. This project aims to develop an automated suicide risk detection system to reduce the incidence and impact of railway suicide, which has a devastating effect on victims’ families, station staff, train drivers, emergency workers, and bystanders. This project will use open-systems theory to develop two complementary information systems for more effective detection and reporting of suic ....Preventing railway suicide: An open-systems perspective. Preventing railway suicide: An open-systems perspective. This project aims to develop an automated suicide risk detection system to reduce the incidence and impact of railway suicide, which has a devastating effect on victims’ families, station staff, train drivers, emergency workers, and bystanders. This project will use open-systems theory to develop two complementary information systems for more effective detection and reporting of suicide risk; use these systems to investigate how different situational factors interact with different combinations of service interventions to influence suicide risk; and share the findings to reduce railway suicide in Australia and overseas.Read moreRead less
Service Ecosystems Management for Collaborative Process Improvement. Australian government agencies currently explore opportunities for streamlining their business processes. A promising approach relates to the improvement of cross-agency processes based on service-enabled technologies. This project will use requirements within Queensland Government for the design of a service ecosystem and methodological and management concepts to derive a general framework for intra-organisational ecosystems. ....Service Ecosystems Management for Collaborative Process Improvement. Australian government agencies currently explore opportunities for streamlining their business processes. A promising approach relates to the improvement of cross-agency processes based on service-enabled technologies. This project will use requirements within Queensland Government for the design of a service ecosystem and methodological and management concepts to derive a general framework for intra-organisational ecosystems. Though the focus will be on government processes, the project will generalise beyond this scope for a wider uptake of service ecosystems in Australian organisations. This will lead to reduced process costs and risks and will leverage the exploration of new revenue streams, e.g. shared services and reward schemes.Read moreRead less
Intelligent Design Advisor for Manufacturing Process Knowledge within Concurrent Engineering in the Aerospace Industry. At present the design of engineering components in the aerospace industry is accomplished by experts from design and manufacturing either sequentially or in collaboration. If performed in sequence then time and quality is jeopardised. If performed in collaboration then more manpower than is necessary is expended. The aim of this project is to develop an intelligent design advis ....Intelligent Design Advisor for Manufacturing Process Knowledge within Concurrent Engineering in the Aerospace Industry. At present the design of engineering components in the aerospace industry is accomplished by experts from design and manufacturing either sequentially or in collaboration. If performed in sequence then time and quality is jeopardised. If performed in collaboration then more manpower than is necessary is expended. The aim of this project is to develop an intelligent design advisor for Manufacturing Process Knowledge that will provide this expert knowledge to the design engineer in order to speed up the design process while reducing costs and still maintaining the high standard of quality necessary in the Aerospace industry.Read moreRead less
An Ontology Driven Framework for Legal Software. Legal resources and documents are increasingly available in electronic form allowing previously impossible collaborative and searching techniques for legal practitioners. By adding extra semantic markup to legal resources and documents increased processing capabilities are enabled. These include the ability to search for resources based on there existing a conceptual link and the ability to integrate resources that use different terminology. This ....An Ontology Driven Framework for Legal Software. Legal resources and documents are increasingly available in electronic form allowing previously impossible collaborative and searching techniques for legal practitioners. By adding extra semantic markup to legal resources and documents increased processing capabilities are enabled. These include the ability to search for resources based on there existing a conceptual link and the ability to integrate resources that use different terminology. This project will enable these capabilities via the development of a novel ontology driven framework for collaborative legal software. This will allow significant efficiency gains and cost savings in the $9.5 billion Australian legal services sector.Read moreRead less
Personalized, Adaptive, and Semantic-driven Selection and Composition of Web Services. Web services are the pillar of the new generation of Internet technologies. They provide standardized access to functionality that would otherwise be hidden inside enterprise information systems. As the existing base of web services expands, there is a need for techniques to select, configure, assemble, and coordinate web services to perform complex user tasks. This project will advance the fundamental underst ....Personalized, Adaptive, and Semantic-driven Selection and Composition of Web Services. Web services are the pillar of the new generation of Internet technologies. They provide standardized access to functionality that would otherwise be hidden inside enterprise information systems. As the existing base of web services expands, there is a need for techniques to select, configure, assemble, and coordinate web services to perform complex user tasks. This project will advance the fundamental understanding and know-how in this area by addressing three complementary research challenges: how to, organize and search semantically rich service descriptions; select services with respect to flexible and personalized criteria; and coordinate services in an adaptive and context-aware manner.Read moreRead less
Application Frameworks for Collaborative Learning. We will pioneer the use of key software engineering techniques - design patterns and application frameworks - to reduce the cost and improve the quality of online collaborative learning activities. For the first time, we will combine software engineering and educational knowledge to use design patterns to describe best practice for these activities in engineering terms; we will use application frameworks to aggregate these patterns and implement ....Application Frameworks for Collaborative Learning. We will pioneer the use of key software engineering techniques - design patterns and application frameworks - to reduce the cost and improve the quality of online collaborative learning activities. For the first time, we will combine software engineering and educational knowledge to use design patterns to describe best practice for these activities in engineering terms; we will use application frameworks to aggregate these patterns and implement them as a readily usable tool. The result will be a powerful new generation of stable collaborative eLearning tools with enhanced scalability, interoperability and adaptability.Read moreRead less
Supply Chain Management and eProcurement. This project will assist Australian firms assess the impact of emerging Internet-enabled electronic business (e-business) initiatives in the area of procurement and supply chain management. The aims are to identify factors that constrain/enable e-procurement in creating sustained value; describe key elements of suceses in the development, application and effective use of e-procurement; provide the basis for assessing progress in understanding and use of ....Supply Chain Management and eProcurement. This project will assist Australian firms assess the impact of emerging Internet-enabled electronic business (e-business) initiatives in the area of procurement and supply chain management. The aims are to identify factors that constrain/enable e-procurement in creating sustained value; describe key elements of suceses in the development, application and effective use of e-procurement; provide the basis for assessing progress in understanding and use of successive waves of innovation in areas of e-procurement and supply chain management; and develop industry benchmarks for critical dimensions of effectiveness in these areas.Read moreRead less