Improving clostridial toxoid production through molecular fermentation maps. This project aims to improve vaccine production by generating detailed molecular maps of fermentation which will be used to design superior fermentation processes with reduced cost. Toxoid vaccines, used routinely in the livestock industry to prevent animal-disease caused by pathogenic Clostridia, are produced using batch fermentation processes. These processes have undergone limited optimisation over the past five deca ....Improving clostridial toxoid production through molecular fermentation maps. This project aims to improve vaccine production by generating detailed molecular maps of fermentation which will be used to design superior fermentation processes with reduced cost. Toxoid vaccines, used routinely in the livestock industry to prevent animal-disease caused by pathogenic Clostridia, are produced using batch fermentation processes. These processes have undergone limited optimisation over the past five decades. Low titres and frequent batch failures greatly affect capital use and represent a significant cost. In addition, current optimisation approaches are limited by the use of expensive and noisy endpoint assays. This project aims to use high-throughput chemistry (multi-omics) that overcome these limitations.Read moreRead less
Redirecting Carbon Flow through Mesophyll and Bundle Sheath Cells of Sugarcane to Produce Poly-3-Hydroxybutyrate. This project is part of the National Priorities "Frontier Technologies for Building and Transforming Australian Industries." Using innovative plant metabolic engineering technologies combined with sophisticated computer modeling we are generating green plants that produce renewable, biodegradable, bioplastics possessing properties such that they are suitable replacements for petrol ....Redirecting Carbon Flow through Mesophyll and Bundle Sheath Cells of Sugarcane to Produce Poly-3-Hydroxybutyrate. This project is part of the National Priorities "Frontier Technologies for Building and Transforming Australian Industries." Using innovative plant metabolic engineering technologies combined with sophisticated computer modeling we are generating green plants that produce renewable, biodegradable, bioplastics possessing properties such that they are suitable replacements for petroleum-derived products in many applications. During the course of these studies, we are increasing our basic level of understanding of plant metabolism of important bioenergy crops. The production of renewable, bioplastics in sugarcane will help to diversify the Australian sugarcane industry by providing a value-added product with significant world-wide markets.Read moreRead less
Engineering cyanobacteria for high-value flavours and fragrances production. Engineering the metabolism of cyanobacteria for industrial production of flavours and fragrances has great commercial potential. Cyanobacteria capture more than 25% of the planet’s carbon. Due to their native metabolism and capacity to express complex plant proteins, they represent an attractive Synthetic Biology platform for the biosynthesis of flavours and fragrances. Combining physiological strain characterisation an ....Engineering cyanobacteria for high-value flavours and fragrances production. Engineering the metabolism of cyanobacteria for industrial production of flavours and fragrances has great commercial potential. Cyanobacteria capture more than 25% of the planet’s carbon. Due to their native metabolism and capacity to express complex plant proteins, they represent an attractive Synthetic Biology platform for the biosynthesis of flavours and fragrances. Combining physiological strain characterisation and ‘omics studies, new Synthetic Biology strategies and models will be developed. The project aims at engineering a suite of modified freshwater and marine cyanobacteria for flavours and fragrances biosynthesis. The project aims at enabling solar biomanufacturing to underpin the emergence of an advanced Australian bioeconomy.Read moreRead less
Developing an integrated systems and synthetic biology platform to expand the product spectrum of acetogens. This project aims to advance a waste gas fermentation process to enable the production of sustainable aviation fuel molecules for the first time. LanzaTech are world leaders in microbial gas fermentation and have produced ethanol at large scale in China. This project aims to combine the LanzaTech process with systems biology expertise at The University of Queensland to go beyond ethanol t ....Developing an integrated systems and synthetic biology platform to expand the product spectrum of acetogens. This project aims to advance a waste gas fermentation process to enable the production of sustainable aviation fuel molecules for the first time. LanzaTech are world leaders in microbial gas fermentation and have produced ethanol at large scale in China. This project aims to combine the LanzaTech process with systems biology expertise at The University of Queensland to go beyond ethanol to deliver new value-added products such as butanediol and farnesene. To achieve this aim the project will explore, understand and overcome fundamental energy and metabolic limitations in the production microorganism. Achieving the aims will be of direct relevance to SkyNRG and the new Brisbane Bioport on their path to deliver sustainable fuel to Brisbane Airport.Read moreRead less
Preventing railway suicide: An open-systems perspective. Preventing railway suicide: An open-systems perspective. This project aims to develop an automated suicide risk detection system to reduce the incidence and impact of railway suicide, which has a devastating effect on victims’ families, station staff, train drivers, emergency workers, and bystanders. This project will use open-systems theory to develop two complementary information systems for more effective detection and reporting of suic ....Preventing railway suicide: An open-systems perspective. Preventing railway suicide: An open-systems perspective. This project aims to develop an automated suicide risk detection system to reduce the incidence and impact of railway suicide, which has a devastating effect on victims’ families, station staff, train drivers, emergency workers, and bystanders. This project will use open-systems theory to develop two complementary information systems for more effective detection and reporting of suicide risk; use these systems to investigate how different situational factors interact with different combinations of service interventions to influence suicide risk; and share the findings to reduce railway suicide in Australia and overseas.Read moreRead less
Service Ecosystems Management for Collaborative Process Improvement. Australian government agencies currently explore opportunities for streamlining their business processes. A promising approach relates to the improvement of cross-agency processes based on service-enabled technologies. This project will use requirements within Queensland Government for the design of a service ecosystem and methodological and management concepts to derive a general framework for intra-organisational ecosystems. ....Service Ecosystems Management for Collaborative Process Improvement. Australian government agencies currently explore opportunities for streamlining their business processes. A promising approach relates to the improvement of cross-agency processes based on service-enabled technologies. This project will use requirements within Queensland Government for the design of a service ecosystem and methodological and management concepts to derive a general framework for intra-organisational ecosystems. Though the focus will be on government processes, the project will generalise beyond this scope for a wider uptake of service ecosystems in Australian organisations. This will lead to reduced process costs and risks and will leverage the exploration of new revenue streams, e.g. shared services and reward schemes.Read moreRead less
UNLOCKING BENEFITS FROM ENTERPRISE SYSTEMS IN THE AUSTRALIAN PUBLIC SECTOR: Benefits Realisation in the Context of the Virtual Organisation. This study proposes to provide an innovative Virtual Organisation perspective to identify factors that can assist Australian government agencies to maximise the potential benefits from Enterprise System (ES) implementation. Study aims include: Identify and explicate major characteristics of the Virtual Organisation created through collaboration between gove ....UNLOCKING BENEFITS FROM ENTERPRISE SYSTEMS IN THE AUSTRALIAN PUBLIC SECTOR: Benefits Realisation in the Context of the Virtual Organisation. This study proposes to provide an innovative Virtual Organisation perspective to identify factors that can assist Australian government agencies to maximise the potential benefits from Enterprise System (ES) implementation. Study aims include: Identify and explicate major characteristics of the Virtual Organisation created through collaboration between government agency and (external) ES Implementation Partner; Identify and document features and constraints peculiar to ES implementation in the Australian public sector; Identify and explicate factors impacting on benefits realisation, relating these to theory from related fields; Highlight consensus and difference among stakeholders; Develop a validated, repeatable methodology for major impact studies; Inform ES research directions.Read moreRead less
Using Measures of Ontological Distance to Evaluate the Alignment between Organizational Needs and Enterprise Systems Capabilities. Enterprise Systems (ES) packages are software systems that seek to provide their organizational users with comprehensive, integrated support for their information system needs. The development, implementation, operation, support, maintenance, and upgrade of enterprise systems is a multi-billion dollar industry. This industry is replete with stories of high-cost pro ....Using Measures of Ontological Distance to Evaluate the Alignment between Organizational Needs and Enterprise Systems Capabilities. Enterprise Systems (ES) packages are software systems that seek to provide their organizational users with comprehensive, integrated support for their information system needs. The development, implementation, operation, support, maintenance, and upgrade of enterprise systems is a multi-billion dollar industry. This industry is replete with stories of high-cost problems. Many of these problems arise because the business models embedded within ES packages do not align with the needs of their users. This project develops a methodology and measures to evaluate how well the business models embedded in an ES package meet user needs.Read moreRead less
Modelling in the Large. Business modelling supports a variety of approaches, which are currently of significant interest for Australian organisations. This includes business process management, risk management or Enterprise Architecture design. The trend to centralised and integrated business modelling leads to projects with a high number of models, modellers, users, and modelling purposes. This phenomenon is called modelling in the large. The proposed research project explores the major issues ....Modelling in the Large. Business modelling supports a variety of approaches, which are currently of significant interest for Australian organisations. This includes business process management, risk management or Enterprise Architecture design. The trend to centralised and integrated business modelling leads to projects with a high number of models, modellers, users, and modelling purposes. This phenomenon is called modelling in the large. The proposed research project explores the major issues within these projects and develops improved modelling techniques and project management approaches for large modelling initiatives. The outcomes will streamline the design, integration, maintenance and communication of models with a focus on Enterprise Systems.Read moreRead less
Reconciling Activity-centric and Business Object-centric Approaches to Business Process Modelling. Business process models are a fundamental instrument for analysing and automating the operations of organisations. At present, the space of business process modelling techniques is characterised by fragmentation with various approaches striking different tradeoffs. Two major families of approaches can be distinguished: activity-centric and business object-centric. These approaches correspond to com ....Reconciling Activity-centric and Business Object-centric Approaches to Business Process Modelling. Business process models are a fundamental instrument for analysing and automating the operations of organisations. At present, the space of business process modelling techniques is characterised by fragmentation with various approaches striking different tradeoffs. Two major families of approaches can be distinguished: activity-centric and business object-centric. These approaches correspond to complementary viewpoints. We see great potential in creating a level of integration between them. Accordingly, the project will investigate the relative expressiveness of these approaches, identify incompatibilities and synergies, and design model transformations. This will establish a foundation for next-generation business process modelling tools.Read moreRead less