Metalloproteomics: A new piece of the systems biology puzzle. Systems biology uses advanced analytical technology to study the complex chemistry of the living cell. Many cellular functions are the result of chemical reactions involving metalloproteins, which are notoriously difficult to study due to the weak bonds between metal and protein that is not normally amenable to traditional proteomic approaches. In partnership with the leading analytical manufacturer Agilent Technologies, this project ....Metalloproteomics: A new piece of the systems biology puzzle. Systems biology uses advanced analytical technology to study the complex chemistry of the living cell. Many cellular functions are the result of chemical reactions involving metalloproteins, which are notoriously difficult to study due to the weak bonds between metal and protein that is not normally amenable to traditional proteomic approaches. In partnership with the leading analytical manufacturer Agilent Technologies, this project aims to adapt and apply advanced mass spectrometry to the study of metalloproteins, developing new methods for studying hundreds of molecules in single experiments. Using the C. elegans model organism the project aims to showcase the importance of metals in biology and develop new solutions for the $2.9 billion proteomics industry.Read moreRead less
Physiology and genetics of barley grain germination in the malting and brewing industries. An international research team will provide new scientific information on barley grain germination. This detailed basic knowledge will be immediately applied in breeding programs that are aimed at improving malting and brewing quality in a commercial context. At the same time, the industry's carbon footprint will be significantly reduced.
Harnessing the 'omics revolution to investigate drug response and resistance mechanisms in Giardia duodenalis. This international research project will harness cutting-edge technologies to explore how Giardia, a major global cause of diarrhoeal illness in humans, responds to and becomes resistant to key anti-giardial drugs, providing valuable information for drug preservation and development.
Novel anti-ageing peptides in the vascular system. The project will substantially improve basic understanding of the ageing process in blood vessels and provide scientific evidence to understand what preventative health care measures might work and why. It will also produce highly skilled and practically trained graduates, ready to contribute to the health industry.
Privacy-Preserving Remote Access to Health Information Infrastructure in Ubiquitous Computing Environments. The project's benefits can be summarised as follows. (a) The project will provide new solutions that enable remote access to health-care data in a secure and privacy-preserving manner. (b) This will improve health care services in northern metropolitan Melbourne, and provide shorter medical response time, which is particularly important in emergency scenarios. (c) It will exemplify advance ....Privacy-Preserving Remote Access to Health Information Infrastructure in Ubiquitous Computing Environments. The project's benefits can be summarised as follows. (a) The project will provide new solutions that enable remote access to health-care data in a secure and privacy-preserving manner. (b) This will improve health care services in northern metropolitan Melbourne, and provide shorter medical response time, which is particularly important in emergency scenarios. (c) It will exemplify advanced IT support for health care, which can be utilised by other providers. (d) The project will make a direct link between IT research and its industrial application. (e) The project will also give the opportunity to a postdoctoral researcher and PhD students to perform leading edge research on privacy protection of information in an industrial environment.Read moreRead less
Use of a cell based assay to identify novel insulin-sensitising agents. Diabetes and obesity are currently escalating to epidemic proportions in Australia and there is an urgent need to develop new therapeutics. A major feature of these disorders is impaired insulin action. We have recently developed and validated an exciting new assay for insulin action in fat cells. In this project we propose an exciting research program encompassing major research and biotechnology groups in Australia to u ....Use of a cell based assay to identify novel insulin-sensitising agents. Diabetes and obesity are currently escalating to epidemic proportions in Australia and there is an urgent need to develop new therapeutics. A major feature of these disorders is impaired insulin action. We have recently developed and validated an exciting new assay for insulin action in fat cells. In this project we propose an exciting research program encompassing major research and biotechnology groups in Australia to utilise this technology to identify novel insulin-sensitising agents. These agents will be used for drug discovery purposes by our industry partner ChemGenex and as novel tools to dissect the mechanism of insulin action.Read moreRead less
A novel Internet-based clinical trial service. The best way to test whether a clinical treatment intervention is effective is a randomised controlled trial (rct). Rcts are expensive, both in terms of resources and time. The internet may provide a method of conducting rcts which is efficent and provides access to those in remote communities. The purpose of this project is to assess the feasibility of developing a structure for conducting rcts using the internet.
Application of Knowledge-Based Engineering (KBE) Technology to Intelligent Design Engineering Systems. Knowledge Based Engineering (KBE) is a systematic approach to the integration of design and manufacturing of products and their related processes, from concept to disposal. Typical for KBE applications is that it accepts design rules and procedures. This makes the design process more efficient, which reduces development cost and product lead time. It also enables knowledge and experience to be ....Application of Knowledge-Based Engineering (KBE) Technology to Intelligent Design Engineering Systems. Knowledge Based Engineering (KBE) is a systematic approach to the integration of design and manufacturing of products and their related processes, from concept to disposal. Typical for KBE applications is that it accepts design rules and procedures. This makes the design process more efficient, which reduces development cost and product lead time. It also enables knowledge and experience to be captured and retained which reduces training cost and makes new staff more effective. The aim of the project is to develop a KBE environment for wire and conduit routing through complex structures and verify the benefits in an industry environment.Read moreRead less
An Organisation Oriented Framework for Collaborative Business Processes. Business integration and enterprise computing is at the heart of ICT objectives and initiatives global wide. The project aims to be of unique value to Australian industry and provide a means to achieve excellence in the field of research that promises to shape the future of e-business technology. The research conducted within this project will position Australia as one of the leaders in the collaborative business process ma ....An Organisation Oriented Framework for Collaborative Business Processes. Business integration and enterprise computing is at the heart of ICT objectives and initiatives global wide. The project aims to be of unique value to Australian industry and provide a means to achieve excellence in the field of research that promises to shape the future of e-business technology. The research conducted within this project will position Australia as one of the leaders in the collaborative business process management area. The project outcomes will provide generic solutions that are applicable to many Australian and international companies involved in B2B collaboration and e-business technologies. Read moreRead less
Virtual Collaborative Logistics and Partner to Partner Information Systems. Increasingly there is a tendency around the world for logistics companies that provide transport and warehousing services to band together to share their physical resources so they can extend their reach beyond their current region of operation. When this is coupled with internet ordering and status monitoring one has an e-logistics company that is a virtual logistics provider that gives access to these shared resources ....Virtual Collaborative Logistics and Partner to Partner Information Systems. Increasingly there is a tendency around the world for logistics companies that provide transport and warehousing services to band together to share their physical resources so they can extend their reach beyond their current region of operation. When this is coupled with internet ordering and status monitoring one has an e-logistics company that is a virtual logistics provider that gives access to these shared resources. Such a virtual collaborative logistics consortium requires very strong partner-to-partner IT support and communication. This project investigates the use of XML (Extensible Mark-up Language) enabled mobile software agents to provide this support.Read moreRead less