Next generation real-time trajectory mining for travel and transportation decision support. Mining human and vehicle trajectories in real time will enable a suite of next-generation applications such as traffic overload prediction, real-time event detection and route recommendation. This project will develop novel techniques for immediate mining of massive volumes of trajectory data as it is being continuously generated.
Linkages between productivity and consistent behavioural traits in fish: implications for harvesting, climate impacts, and selective breeding for aquaculture. The extent to which behavior, growth and reproduction are genetically linked in fish populations is unknown, but critical for predicting the impacts of fish harvesting and climate warming, and developing fish stains for aquaculture. If strongly linked, fish harvest will always remove aggressive, large and productive fish, requiring their p ....Linkages between productivity and consistent behavioural traits in fish: implications for harvesting, climate impacts, and selective breeding for aquaculture. The extent to which behavior, growth and reproduction are genetically linked in fish populations is unknown, but critical for predicting the impacts of fish harvesting and climate warming, and developing fish stains for aquaculture. If strongly linked, fish harvest will always remove aggressive, large and productive fish, requiring their protection; in aquaculture, selecting for productive fish will also increase aggression-related injuries. If not strongly linked, we may be able to select for high productivity and low aggression in fish, or high productivity and low metabolism, thus reducing feed costs in aquaculture associated with aggressive behaviour leading to injury and infection, and reduced growth at warmer temperatures.Read moreRead less
Bias and allostery at the calcium sensing receptor. This project aims to provide a mechanistic and dynamic picture of the structure, function and physiology of the human calcium sensing receptor (CaSR), which is critical for vertebrate life. By responding to chemicals in the body, it acts as a universal nutrient sensor to maintain extracellular calcium homeostasis and mediate biological functions, including neurotransmission, inflammation, digestion, blood pressure and development. However, it i ....Bias and allostery at the calcium sensing receptor. This project aims to provide a mechanistic and dynamic picture of the structure, function and physiology of the human calcium sensing receptor (CaSR), which is critical for vertebrate life. By responding to chemicals in the body, it acts as a universal nutrient sensor to maintain extracellular calcium homeostasis and mediate biological functions, including neurotransmission, inflammation, digestion, blood pressure and development. However, it is not known how this single receptor controls the actions of multiple ligands to mediate numerous functions. By elucidating the roles of the CaSR and its ligands, this project aims to better understand fundamental physiological processes.Read moreRead less
Expanding the molecular tool set for structural studies of proteins and their complexes. Many applications in medical science and drug development depend on our ability to determine the 3D structures of proteins, protein assemblies and protein-ligand complexes. This project will develop novel lanthanide-binding tags and crosslinking agents that can be coupled to unnatural amino acids introduced into proteins with advanced protein chemistry techniques. These new tools will facilitate the collecti ....Expanding the molecular tool set for structural studies of proteins and their complexes. Many applications in medical science and drug development depend on our ability to determine the 3D structures of proteins, protein assemblies and protein-ligand complexes. This project will develop novel lanthanide-binding tags and crosslinking agents that can be coupled to unnatural amino acids introduced into proteins with advanced protein chemistry techniques. These new tools will facilitate the collection of structure restraints by nuclear magnetic resonance (NMR), electron paramagnetic resonance (EPR) and mass spectrometry, which are needed to generate accurate models of proteins and their complexes with other molecules. Major beneficial outcome will include an increase in the number of protein targets amenable to rational drug design and improved methods for generating new drug leads.Read moreRead less
The convective boundaries in stars. This project aims to locate the boundaries of convection, a problem in models of stars. It will calculate high-resolution three-dimensional simulations of stars and observe star clusters. The effect of this advance on stellar modelling could be profound since almost all stars contain convective regions. Many branches of astronomy rely on stellar models so the effect could extend far beyond the immediate field, ultimately expanding understanding of the Universe ....The convective boundaries in stars. This project aims to locate the boundaries of convection, a problem in models of stars. It will calculate high-resolution three-dimensional simulations of stars and observe star clusters. The effect of this advance on stellar modelling could be profound since almost all stars contain convective regions. Many branches of astronomy rely on stellar models so the effect could extend far beyond the immediate field, ultimately expanding understanding of the Universe. It could also be crucial in realising the scientific advances of the surveys which are gathering data for up to a billion stars.Read moreRead less
School retention and second chance schooling. This project is concerned with ensuring that students who experience systemic disadvantage are not excluded from the benefits of a formal education. It provides an account and critique of the growth of second chance schooling options catering to such students in both Australia and the UK.
Ancient stars: the origin of elements. The story of the origin of the elements fascinates mankind and touches many branches of science. This project combines new stellar population models of the oldest stars with new data from the Australian million-star GALactic Archaeology with HERMES (GALAH) survey to address basic astrophysical problems: mixing in stars, mass transfer in binary stars and measurement of the masses of the first stars. Knowing how these ancient stars behave is crucial to unders ....Ancient stars: the origin of elements. The story of the origin of the elements fascinates mankind and touches many branches of science. This project combines new stellar population models of the oldest stars with new data from the Australian million-star GALactic Archaeology with HERMES (GALAH) survey to address basic astrophysical problems: mixing in stars, mass transfer in binary stars and measurement of the masses of the first stars. Knowing how these ancient stars behave is crucial to understanding element production in the early Universe, both in our Milky Way and distant galaxies. By statistically comparing new models to the GALAH data, this project aims to measure the masses of the oldest galactic stars directly impacting branches of astrophysics from planets to galaxies.Read moreRead less