Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0667981
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
Kangaroo Genome Resource Management Facility. Increasingly, large Australian multicentre research programs in biological and medical sciences have a genomics component that involves integration of biological information with sequencing data. The success of these research programs depends on rapid internet access to the research information by all participating scientists. The universal design of the proposed information management system means that it can be easily adapted to support a broad ran ....Kangaroo Genome Resource Management Facility. Increasingly, large Australian multicentre research programs in biological and medical sciences have a genomics component that involves integration of biological information with sequencing data. The success of these research programs depends on rapid internet access to the research information by all participating scientists. The universal design of the proposed information management system means that it can be easily adapted to support a broad range of research programs. The development of this software program therefore has the potential to benefit research scientists, academics and students in many related fields, as well as the broader community, through enhancing research outcomes.Read moreRead less
The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which ....The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which sex genes are targets? Epigenetic enzymes are astonishingly conserved, providing exciting opportunities to draw from human systems to unravel novel signatures of temperature-induced sex switching in reptiles. This project will advance knowledge of developmental programming generally.Read moreRead less
Genomic and molecular characterisation of a novel Australian leishmania pathogen. Leishmaniasis is the second most serious protozoal disease after malaria. This project will help characterise the first Leishmania species identified in Australia providing molecular tools to monitor the pathogen and a detailed assessment of any potential risk to human health. Comparative analysis with more pathogenic species will help identify genes and mechanisms that determine the progression of human disease le ....Genomic and molecular characterisation of a novel Australian leishmania pathogen. Leishmaniasis is the second most serious protozoal disease after malaria. This project will help characterise the first Leishmania species identified in Australia providing molecular tools to monitor the pathogen and a detailed assessment of any potential risk to human health. Comparative analysis with more pathogenic species will help identify genes and mechanisms that determine the progression of human disease leading to the potential identification of new drug and vaccine targets. The methodologies and expertise developed will be used will be available to other research groups working on infectious diseases.Read moreRead less
Special Research Initiatives - Grant ID: SR0354729
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Smart Use of Information Technologies (SUITs). The SUITs network will develop critical mass in world-class, leading-edge research into the smart use of information and communication technology (ICT) through integration of research within the dispersed Australian ICT research community and through facilitating international linkages. The network will undertake research applicable in key sectors including the health, education, service, knowledge and media industries. The aim is to establish a h ....Smart Use of Information Technologies (SUITs). The SUITs network will develop critical mass in world-class, leading-edge research into the smart use of information and communication technology (ICT) through integration of research within the dispersed Australian ICT research community and through facilitating international linkages. The network will undertake research applicable in key sectors including the health, education, service, knowledge and media industries. The aim is to establish a higher order of coordination and collaboration in research into ICT applications.
The feasibility study proposed will engage key stakeholders, refine research goals and investigate linkage mechanisms to improve Australia's ICT research and its contribution to economic and social well-being.
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How do qualifications delivered by enterprises contribute to improved skill levels and other benefits for companies, workers and the nation? This project investigates the role of employer-based qualifications training in developing the skills and prospects of the Australian workforce and the competitive capabilities of companies. It focuses on enterprises that are accredited to deliver qualifications to their own workers, providing data to improve and expand this form of training.
ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the ....ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the whole genome as large inserts in BAC vectors, and build a "golden path" with minimal overlap. We will construct libraries of expressed genes from tammar tissues and array them for use in analysing gene expression.Read moreRead less
Strabismus is the pathological misalignment of the eyes associated with loss of binocular vision and is one of the most common human ophthalmological disorders. Patients with comitant strabismus have full eye movements, whereas patients with incomitant strabismus have limited eye movements, which causes the angle of strabismus to vary with gaze direction. This project aims to define genetic contributors to comitant congenital strabismus.
Stochastic Geometry for Multi-sensor Data Fusion System. The aim of this project is to develop efficient algorithms for tracking and sensor management in a multi-sensor multi-target environment. Finite random set theory provides a natural way of representing a random number of (random) object states, an issue that has been largely ignored in the tracking literature until recently. Although a satisfactory foundation for multiple object filtering has been provided by random set theory, in this ear ....Stochastic Geometry for Multi-sensor Data Fusion System. The aim of this project is to develop efficient algorithms for tracking and sensor management in a multi-sensor multi-target environment. Finite random set theory provides a natural way of representing a random number of (random) object states, an issue that has been largely ignored in the tracking literature until recently. Although a satisfactory foundation for multiple object filtering has been provided by random set theory, in this early stage no algorithm capable of tracking many targets has emerged from this framework. We are confident that efficient algorithms can be developed by exploiting the insights and mathematical tools of stochastic geometryRead moreRead less
High Penetrance Deleterious Mutations In Blinding Glaucoma
Funder
National Health and Medical Research Council
Funding Amount
$1,345,055.00
Summary
This project aims to identify the genes most commonly mutated in individuals with advanced glaucoma. Identification of such genes will lead to improved understanding of glaucoma pathogenesis, a better ability to predict risk, and the identification of drug targets for novel therapies.