The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which ....The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which sex genes are targets? Epigenetic enzymes are astonishingly conserved, providing exciting opportunities to draw from human systems to unravel novel signatures of temperature-induced sex switching in reptiles. This project will advance knowledge of developmental programming generally.Read moreRead less
Stochastic Geometry for Multi-sensor Data Fusion System. The aim of this project is to develop efficient algorithms for tracking and sensor management in a multi-sensor multi-target environment. Finite random set theory provides a natural way of representing a random number of (random) object states, an issue that has been largely ignored in the tracking literature until recently. Although a satisfactory foundation for multiple object filtering has been provided by random set theory, in this ear ....Stochastic Geometry for Multi-sensor Data Fusion System. The aim of this project is to develop efficient algorithms for tracking and sensor management in a multi-sensor multi-target environment. Finite random set theory provides a natural way of representing a random number of (random) object states, an issue that has been largely ignored in the tracking literature until recently. Although a satisfactory foundation for multiple object filtering has been provided by random set theory, in this early stage no algorithm capable of tracking many targets has emerged from this framework. We are confident that efficient algorithms can be developed by exploiting the insights and mathematical tools of stochastic geometryRead moreRead less
Convex optimisation for control, signal processing and communication systems. Renewable control of complex systems, signal processing, telecommunication and in general any industries interested in these applications stand to benefit from our research. In particular, the automotive and defence industries stand to benefit from the nonlinear control design aspect of the proposed project outcomes. The
telecommunications industries, on the other hand, benefit from the signal processing and communicat ....Convex optimisation for control, signal processing and communication systems. Renewable control of complex systems, signal processing, telecommunication and in general any industries interested in these applications stand to benefit from our research. In particular, the automotive and defence industries stand to benefit from the nonlinear control design aspect of the proposed project outcomes. The
telecommunications industries, on the other hand, benefit from the signal processing and communications aspects. We also build a core expertise in optimisation and its applications in Australia by training PhD students and Postdoctoral researchers. The research collaborations will cement and maintain the international linkages which will improve applied research in AustraliaRead moreRead less
Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family protei ....Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family proteins as specific effectors. This project will address a new paradigm in genetics that is likely to underpin development.Read moreRead less
Sex determination in dragons: Genetics, epigenetics and environment. This project aims to discover the master sex-determining gene in a reptile, how that gene is differentially regulated in males and females and by temperature, and to identify evolutionary drivers of transitions between genetic and environmental sex determination. In many reptiles, like mammals, chromosomes determine sex. In others, the temperature at which their eggs are incubated determines sex. This project will study how tem ....Sex determination in dragons: Genetics, epigenetics and environment. This project aims to discover the master sex-determining gene in a reptile, how that gene is differentially regulated in males and females and by temperature, and to identify evolutionary drivers of transitions between genetic and environmental sex determination. In many reptiles, like mammals, chromosomes determine sex. In others, the temperature at which their eggs are incubated determines sex. This project will study how temperature reverses chromosomal sex determination in dragon lizards. This could show how climatic extremes affect the biology of climate sensitive reptiles, and understand their vulnerability to climate change.Read moreRead less
Non-local equations at work. This project aims to study non-local fractional equations. These problems arise naturally in many fields of pure and applied mathematics. This project will consider symmetry and rigidity results; problems from atom dislocation theory; nonlocal minimal surfaces; symbolic dynamics for nonlocal equations; and free boundary problems. This project aims to obtain substantial progress in this field, both from the point of view of the mathematical theory and in view of concr ....Non-local equations at work. This project aims to study non-local fractional equations. These problems arise naturally in many fields of pure and applied mathematics. This project will consider symmetry and rigidity results; problems from atom dislocation theory; nonlocal minimal surfaces; symbolic dynamics for nonlocal equations; and free boundary problems. This project aims to obtain substantial progress in this field, both from the point of view of the mathematical theory and in view of concrete applications. This project should contribute to the development of the mathematical theory and give insight for concrete applications in physics and biology.Read moreRead less
Modelling and estimation methods for discrete multi-dimensional systems. Multi-dimensional signal processing plays a role in a variety of application areas, ranging from remote sensing for environmental monitoring and geological mapping, to medical imaging and the automatic control of industrial processes. The success of the project will provide mathematical tools for the advancement of the state-of-the-art in these broad areas.
Effective and Efficient Query Processing over Dynamic Social Networks. This project aims to invent novel query-based social network data exploration techniques which would help individuals or organisations make smart decisions based on data from increasingly massive, complex and dynamic social networks. Expected project outcomes are formal result semantics, advanced indices, efficient query evaluation algorithms and scalable techniques for three types of commonly used queries. The project plans ....Effective and Efficient Query Processing over Dynamic Social Networks. This project aims to invent novel query-based social network data exploration techniques which would help individuals or organisations make smart decisions based on data from increasingly massive, complex and dynamic social networks. Expected project outcomes are formal result semantics, advanced indices, efficient query evaluation algorithms and scalable techniques for three types of commonly used queries. The project plans to develop a system prototype to evaluate the effectiveness and efficiency of the proposed approaches and techniques. Query-based dynamic social network data exploration techniques developed in this project may have practical applications including event and influential topic discovery and tracking, buying trend analysis and political issues analysis.Read moreRead less
Elder Abuse: A Longitudinal Prospective Study of Perpetrators and Victims. This project aims to improve the quality of the available data and fill major gaps in knowledge about elder abuse in Australia. The study is significant as it aims to generate new knowledge about the perpetrators and victims of abuse and neglect of older women. The Council of Attorneys’ General of Australia has explicitly prioritised this need for further research on the population prevalence of elder abuse. The anticipat ....Elder Abuse: A Longitudinal Prospective Study of Perpetrators and Victims. This project aims to improve the quality of the available data and fill major gaps in knowledge about elder abuse in Australia. The study is significant as it aims to generate new knowledge about the perpetrators and victims of abuse and neglect of older women. The Council of Attorneys’ General of Australia has explicitly prioritised this need for further research on the population prevalence of elder abuse. The anticipated project outcomes will be to identify the prevalence, causes and consequences of elder abuse in Australia, with the intended benefit of the development of reliable and validated estimates of the population prevalence of elder abuse and identify the early life and current circumstances of women who experience elder abuse.
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Marsupial germ cells and genes. Germ cells are the most fascinating cells in the body, since theirs is the unique responsibility for transmitting life from generation to generation. Studies in mice have suggested that position in the embryo determines their origin, but the early embryology of the mouse is so different from that of other mammals that the events need confirming and extending in another species. The simplified embryology of the tammar wallaby makes it ideal for studying one of the ....Marsupial germ cells and genes. Germ cells are the most fascinating cells in the body, since theirs is the unique responsibility for transmitting life from generation to generation. Studies in mice have suggested that position in the embryo determines their origin, but the early embryology of the mouse is so different from that of other mammals that the events need confirming and extending in another species. The simplified embryology of the tammar wallaby makes it ideal for studying one of the most fundamental questions in the whole of biology: what is the basis for the primal distinction between sex and soma?Read moreRead less