Microenvironments which support extramedullary hematopoiesis. Tissue regeneration is a breakthrough technology absolutely dependent on knowledge of the stem cells and stromal cells which support differentiation and tissue development. This project investigates the stromal cell types in spleen which can regenerate blood-forming cells in an ectopic tissue site or artificial matrix.
ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory ne ....ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory networks and to address how environmental factors impinge on these regulatory networks. The formation of this National Research Network is unique, timely and strategic. It will generate new insights into the mechanisms by which events in early life determine the risk of adverse outcomes in perinatal and adult life.Read moreRead less
The mighty ape’s last stand. This project aims to study the fate of primates in southern Asia, where evidence for megafaunal extinction is rare. Why Gigantopithecus blacki, the largest ever primate, disappeared is unknown, while humans in the region survived. This project will model dating techniques across sites to identify a precise extinction window and compare behaviour and past environmental conditions to determine why the ape failed and man persevered. Outcomes will generate a new understa ....The mighty ape’s last stand. This project aims to study the fate of primates in southern Asia, where evidence for megafaunal extinction is rare. Why Gigantopithecus blacki, the largest ever primate, disappeared is unknown, while humans in the region survived. This project will model dating techniques across sites to identify a precise extinction window and compare behaviour and past environmental conditions to determine why the ape failed and man persevered. Outcomes will generate a new understanding of past environmental change as a driver of megafaunal extinction in comparison with human adaption and survival.Read moreRead less
ARC Centre of Excellence for the Elimination of Violence Against Women. ARC Centre of Excellence for the Elimination of Violence Against Women. Eliminating violence against women is one of the major challenges of the 21st century. Awareness of the problem has grown exponentially, but solutions to it have not. This Centre aims to transform our understanding of the problem by examining the structural drivers that cause and compound violence against women, and pioneering new, evidence-based approac ....ARC Centre of Excellence for the Elimination of Violence Against Women. ARC Centre of Excellence for the Elimination of Violence Against Women. Eliminating violence against women is one of the major challenges of the 21st century. Awareness of the problem has grown exponentially, but solutions to it have not. This Centre aims to transform our understanding of the problem by examining the structural drivers that cause and compound violence against women, and pioneering new, evidence-based approaches to radically improve policy and practice across Australia and the Indo-Pacific. The Centre mobilises survivor-centric and Indigenous methodologies, interdisciplinary collaborations, and Indo-Pacific partnerships to deliver scalable approaches to eliminate violence against women across the legal, security, economic, health, and political systems of Australia and the region.Read moreRead less
How does your garden grow? Scaling functional traits to whole-plant growth. Understanding how the traits of leaves and stems influence plant growth is important because plant growth drives emergent ecosystem properties such as rates of water use and carbon and nitrogen cycling. The project will build a new understanding of trait-growth relationships, focusing on species from four Australian forest types.
Bubble, Bubble CO2 is the trouble: A Natural Ocean Acidification Experiment in a coral reef setting. Carbon dioxide seep sites expose shallow coral reefs in Papua New Guinea to volcanic carbon dioxide resulting in gradients of seawater ranging from pH 8.0 (normal) to a more acidic pH of 7.5. Some areas of these reefs experience carbon dioxide exposure equivalent to IPCC predictions for 2050 and 2100. This project will reconstruct seawater pH using radiocarbon as a novel tracer of carbon dioxide ....Bubble, Bubble CO2 is the trouble: A Natural Ocean Acidification Experiment in a coral reef setting. Carbon dioxide seep sites expose shallow coral reefs in Papua New Guinea to volcanic carbon dioxide resulting in gradients of seawater ranging from pH 8.0 (normal) to a more acidic pH of 7.5. Some areas of these reefs experience carbon dioxide exposure equivalent to IPCC predictions for 2050 and 2100. This project will reconstruct seawater pH using radiocarbon as a novel tracer of carbon dioxide input at a coral reef site that has been exposed to high carbon dioxide due to volcanic seeps (seep carbon dioxide has no carbon-14) for an unknown period of time (at least many decades, but possibly centuries). These results will help to understand the time it takes to change calcifying organisms into “winners” or “losers” as an analog for Ocean Acidification due to increased atmospheric carbon dioxide input.Read moreRead less
Special Research Initiatives - Grant ID: SR0354797
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
The Australian Tissue Engineering Network. Driven by four key nodes across the country, the Initiative aims to bring together geographically and financially separated groups into a critical mass of cell and tissue engineering research. This new and rapidly-growing field uses a bio-synthetic approach to replace, repair or regenerate damaged tissues and organs. The Initiative will build the framework which will enable the Network to: identify appropriate expertise, manage duplication, enhance co ....The Australian Tissue Engineering Network. Driven by four key nodes across the country, the Initiative aims to bring together geographically and financially separated groups into a critical mass of cell and tissue engineering research. This new and rapidly-growing field uses a bio-synthetic approach to replace, repair or regenerate damaged tissues and organs. The Initiative will build the framework which will enable the Network to: identify appropriate expertise, manage duplication, enhance communication, bring together innovative skill sets, create linkages, generate focussed research programs and foster novel commercial opportunities. Ultimately the Initiative and Network will deliver an improved quality of life, reduced healthcare costs, and increased productivity to Australia.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100157
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Confocal and single molecule microscopes for systems microscopy. This project aims to establish Australia’s first system microscopy facility with dedicated live-cell confocal and single-molecule fluorescence microscopes. In systems microscopy, the imaging workflow is automated so that large and unbiased data sets of the spatiotemporal organisation of molecules and cells can be generated. Combined with statistical and bioinformatics analyses, image-derived data provides system-wide information th ....Confocal and single molecule microscopes for systems microscopy. This project aims to establish Australia’s first system microscopy facility with dedicated live-cell confocal and single-molecule fluorescence microscopes. In systems microscopy, the imaging workflow is automated so that large and unbiased data sets of the spatiotemporal organisation of molecules and cells can be generated. Combined with statistical and bioinformatics analyses, image-derived data provides system-wide information that is not easily obtainable with other approaches. The project will enable Australian researchers to image and analyse the full complexity of biological systems, potentially transforming cell biology, drug development and understanding the molecular basis of disease. It will also demonstrate how the capacity of microscopy facilities can be enhanced and bias in imaging data reduced by automating data acquisition and mining of image-based data.Read moreRead less
Sino-Australian neurogenetics initiative. This project will undertake large population studies to identify genes that are associated with motor neuron disease, schizophrenia and intracranial haemorrhage. The project will determine genetic markers, aid development of diagnostic tools and identify new therapeutic targets for these common heritable neurological diseases.
Global integration of microbial community and climate data. Microbial communities in the environment control the cycling of carbon and nutrients on Earth, but climate models do not directly incorporate microbial inputs. This interdisciplinary project will link planetary-scale climate modelling data with novel large-scale microbial community analysis, using climate information to provide insight into the fantastic diversity of microbial processes on our planet. The interdisciplinary approach will ....Global integration of microbial community and climate data. Microbial communities in the environment control the cycling of carbon and nutrients on Earth, but climate models do not directly incorporate microbial inputs. This interdisciplinary project will link planetary-scale climate modelling data with novel large-scale microbial community analysis, using climate information to provide insight into the fantastic diversity of microbial processes on our planet. The interdisciplinary approach will inform the next generation of climate models and better predict our future climate’s feedbacks. Conversely, it will make progress on the grand challenge of understanding microbial community function by enabling microbial ecology to be treated as a data-intensive machine learning problem.Read moreRead less