Macrophage control of mammalian growth and development. The immediate postnatal period in mammals is crucial for survival, long term health and productivity. This project is an international collaboration that aims to investigate how cells of the innate immune system called macrophages control somatic growth and development of mature organ function in the early postnatal period. The project aims to build upon investment in new animals models and a novel discovery to generate significant new know ....Macrophage control of mammalian growth and development. The immediate postnatal period in mammals is crucial for survival, long term health and productivity. This project is an international collaboration that aims to investigate how cells of the innate immune system called macrophages control somatic growth and development of mature organ function in the early postnatal period. The project aims to build upon investment in new animals models and a novel discovery to generate significant new knowledge that will challenge current concepts of mammalian growth control. The outcomes will enhance Australia's international reputation in the fields of physiology, immunology and developmental biology. Read moreRead less
Mechanisms of acclimation of coralline algae to ocean acidification. This project aims to investigate the biological and ecological mechanisms by which reef-building coralline algae may have survived past ocean acidification and warming events and may acclimate to future changes. Coralline algae play critical roles in coral reef ecology but are sensitive to human-induced ocean acidification. However, the abundant geological record coincident with past acidification events is inconsistent with th ....Mechanisms of acclimation of coralline algae to ocean acidification. This project aims to investigate the biological and ecological mechanisms by which reef-building coralline algae may have survived past ocean acidification and warming events and may acclimate to future changes. Coralline algae play critical roles in coral reef ecology but are sensitive to human-induced ocean acidification. However, the abundant geological record coincident with past acidification events is inconsistent with their sensitivity to high carbon dioxide. Acclimation and adaptation is therefore possible but in ways we do not yet understand. The project expects to provide insights to the ability of key marine organisms to acclimate to rapid environmental change and provide information critical for the conservation of valuable marine systems.Read moreRead less
Resolving human-flying fox conflict in the face of environmental change. Resolving human-flying fox conflict in the face of environmental change. This project aims to identify socially-acceptable priority areas to be managed for the long-term viability of flying-foxes under a changing climate, and develop strategies to mitigate human-flying fox conflict, using ecological and social analysis in a decision-theoretic framework. Flying-foxes are nationally protected mammals pivotal to Australia’s fo ....Resolving human-flying fox conflict in the face of environmental change. Resolving human-flying fox conflict in the face of environmental change. This project aims to identify socially-acceptable priority areas to be managed for the long-term viability of flying-foxes under a changing climate, and develop strategies to mitigate human-flying fox conflict, using ecological and social analysis in a decision-theoretic framework. Flying-foxes are nationally protected mammals pivotal to Australia’s forest ecosystems, but are threatened by habitat loss, extreme weather and legal culls at orchards. Their exceptional mobility puts them in frequent conflict with human settlements, leading to forced dispersals from roosts. Anticipated outcomes are the conservation of Australia’s flying-foxes and international understanding of how to resolve human conflict with highly mobile species that are threatened but locally abundant and controversial.Read moreRead less
Gauging the value of flexible learning options for disenfranchised youth and the Australian community. Investment in flexible learning options (FLOs) for young people who have disengaged from schooling requires understanding of how they work and evidence about their economic and social value. This project will provide both through innovative and integrated methods, analysing FLO sites across three Australian states and the Northern Territory.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100075
Funder
Australian Research Council
Funding Amount
$315,000.00
Summary
Acoustic liquid handling robotics for bioactive compound discovery. This project aims to use a Labcyte Echo 550 acoustic dispenser with Combination Software to deliver sophisticated assay-ready screening. The Echo is the only liquid handling dispenser for 1536-well microplates and will allow Australian researchers to develop assay miniaturisation. The robotics will provide our nation’s researchers with a distinct competitive edge by enhancing assay sophistication, accuracy and reproducibility wh ....Acoustic liquid handling robotics for bioactive compound discovery. This project aims to use a Labcyte Echo 550 acoustic dispenser with Combination Software to deliver sophisticated assay-ready screening. The Echo is the only liquid handling dispenser for 1536-well microplates and will allow Australian researchers to develop assay miniaturisation. The robotics will provide our nation’s researchers with a distinct competitive edge by enhancing assay sophistication, accuracy and reproducibility while reducing cost. The expected benefits will advance the elucidation of molecular mechanisms involved in complex biological phenomena. The benefits of this are substantial, including reduction in test compound and reagents, which in turn reduces laboratory costs, conserves cells and increases data quality.Read moreRead less
Criminalisation of poverty and homelessness in Australia: A national study. The project aims to assess the policing and enforcement of public order crimes and related offences (e.g. obstruct/disobey police, breach of bail, and minor property offences) on individuals experiencing poverty and homelessness. The project endeavours to collect and analyse qualitative data from across Australia on the lived experience of people who are homeless or at risk of homelessness, regarding the impact of crimin ....Criminalisation of poverty and homelessness in Australia: A national study. The project aims to assess the policing and enforcement of public order crimes and related offences (e.g. obstruct/disobey police, breach of bail, and minor property offences) on individuals experiencing poverty and homelessness. The project endeavours to collect and analyse qualitative data from across Australia on the lived experience of people who are homeless or at risk of homelessness, regarding the impact of criminal laws and police powers concerned with presence in, and movement around public places. It will particularly focus on the impact on women, children and Indigenous peoples. The outcomes will seek to reduce the criminalisation of homeless people, by identifying law and policy reform options, and comparing their cost with that of 'business as usual'.Read moreRead less
Aboriginal and non-Aboriginal sex-offenders in Australia: Assessing risk for practice and policy. A key priority of Australian governments is to improve community safety through reducing the risk of sex offenders re-offending after release from prison. This project will assess the validity of tools used to predict the risk of sexual offender recidivism and identify alternate risk assessment tools for Indigenous and non-Indigenous sex offenders.
The last glaciation maximum climate conundrum and environmental responses of the Australian continent to altered climate states. This project will show how climate systems in south east Australia responded to large scale global change the last time this happened, which was about 21,000 years ago. By determining the climate response in Australia to this change, this project will help predict future response in rainfall and temperature to human-induced and natural climate change.
ARC/NHMRC Research Network in Ageing Well. The ARC Research Network on Ageing Well will support interdisciplinary, high quality research in the National Research Priority Goal of Ageing Well, Ageing Productively. It will build scale and focus on Australia's notable research strengths in ageing, promote collaborative research, and extend research capacities. The Network will link outstanding researchers from many disciplines, nurture developing researchers, relate social to health researchers, s ....ARC/NHMRC Research Network in Ageing Well. The ARC Research Network on Ageing Well will support interdisciplinary, high quality research in the National Research Priority Goal of Ageing Well, Ageing Productively. It will build scale and focus on Australia's notable research strengths in ageing, promote collaborative research, and extend research capacities. The Network will link outstanding researchers from many disciplines, nurture developing researchers, relate social to health researchers, strengthen international collaboration, and involve and inform end-point users. It will foster research which responds to the aspirations and needs of older Australians and informs action that can improve experiences of individual and population ageing.Read moreRead less
Climate-driven windblown dust and flood runoff can increase marine diseases by fungal pathogens. Determination of the role of fungal pathogens in marine disease outbreaks, and their linkages to climate-driven dust and flood events, have important applications for coastal fisheries and the Great Barrier Reef. This project will develop molecular tools and plankton recorder protocols to detect fungal outbreaks and assess ecosystem resilience.