Quantifying vertical and lateral ocean transport due to fronts and eddies. This project aims to quantify the intensity and location of ocean currents at unprecedented fine spatial scales by using data from a new generation of high-resolution satellites. These fine scales dominate the lateral and vertical transport of ocean-borne material, including heat, larvae and pollutants like oil and plastics, yet are poorly understood. New algorithms for processing satellite data will be developed and test ....Quantifying vertical and lateral ocean transport due to fronts and eddies. This project aims to quantify the intensity and location of ocean currents at unprecedented fine spatial scales by using data from a new generation of high-resolution satellites. These fine scales dominate the lateral and vertical transport of ocean-borne material, including heat, larvae and pollutants like oil and plastics, yet are poorly understood. New algorithms for processing satellite data will be developed and tested using in situ data in the significant North West Shelf region. Expected outcomes will be novel methods to identify ocean currents and a paradigm shift in quantification of fine-scale ocean dynamics. This will benefit operational oceanography in the areas of maritime safety, defence, fisheries and the offshore industry.Read moreRead less
Development of novel inerter-based damper for platform vibration control. This project aims to develop a novel inerter-based damper to mitigate the excessive vibrations of offshore floating platforms (OFP), which are widely used in the offshore industry for oil exploration. Harsh environmental loads such as wind and waves can induce excessive vibrations to OFPs and endanger their safety and stability. This project aims to develop a novel inerter-based damper that can produce a considerable appar ....Development of novel inerter-based damper for platform vibration control. This project aims to develop a novel inerter-based damper to mitigate the excessive vibrations of offshore floating platforms (OFP), which are widely used in the offshore industry for oil exploration. Harsh environmental loads such as wind and waves can induce excessive vibrations to OFPs and endanger their safety and stability. This project aims to develop a novel inerter-based damper that can produce a considerable apparent mass that is much larger than its physical mass through an amplifying mechanism by translating the linear motion into high-speed rotational motion, which can significantly reduce the mass and cost of the damper. Benefits of the project include more economical and safer OFP designs, which are expected to improve the competitiveness of Australian pillar oil and gas industries.Read moreRead less
Re-uniting marsupials and eutherians by embryonic micromanipulation. The unique responsibility for transmitting life from generation to generation normally depends on the gametes. This project will use new reproductive technologies to investigate the properties of the oocyte in reprogramming somatic cell nuclei, and will use the nuclei of both marsupial and eutherian somatic cells to test this. We will also use both marsupial and eutherian genes to insert into the oocyte to create the first tra ....Re-uniting marsupials and eutherians by embryonic micromanipulation. The unique responsibility for transmitting life from generation to generation normally depends on the gametes. This project will use new reproductive technologies to investigate the properties of the oocyte in reprogramming somatic cell nuclei, and will use the nuclei of both marsupial and eutherian somatic cells to test this. We will also use both marsupial and eutherian genes to insert into the oocyte to create the first transgenic marsupials. We will also investigate the ability of spermatozoa from species of increasing genetic distance to ferttilise marsupial eggs using intracytoplasmic sperm injection (ICSI).Read moreRead less
An X-ray crystallographic investigation into co-receptors on T-lymphocytes. T lymphocytes are an indispensable cellular component of the immune system. The normal process of T cell selection in the thymus, and the ability of mature T cells to respond to foreign antigens are governed by receptor recognition and co-receptor mediated events. The co-receptors encompass a wide spectrum of structurally diverse proteins that are involved in adhesion, co-ligation and signal transduction. This proposa ....An X-ray crystallographic investigation into co-receptors on T-lymphocytes. T lymphocytes are an indispensable cellular component of the immune system. The normal process of T cell selection in the thymus, and the ability of mature T cells to respond to foreign antigens are governed by receptor recognition and co-receptor mediated events. The co-receptors encompass a wide spectrum of structurally diverse proteins that are involved in adhesion, co-ligation and signal transduction. This proposal aims to investigate, using X-ray crystallography as the primary research tool, co- receptors located on T-lymphocytes. This work will gain fundamental insights into co-receptor function.Read moreRead less
The role of internal wave-driven near-bed turbulent dynamics in coastal ocean sediment mobilisation. This project will determine the process of internal wave-driven sediment resuspension and transport in the coastal ocean. This will be achieved by using a combination of field observations and numerical modelling, at two diverse but representative Australian coastal regions where nonlinear internal waves dominate the dynamics. The study has significant application to the offshore oil and gas indu ....The role of internal wave-driven near-bed turbulent dynamics in coastal ocean sediment mobilisation. This project will determine the process of internal wave-driven sediment resuspension and transport in the coastal ocean. This will be achieved by using a combination of field observations and numerical modelling, at two diverse but representative Australian coastal regions where nonlinear internal waves dominate the dynamics. The study has significant application to the offshore oil and gas industry engineering design and operations as well as to environmental management of the coastal ocean ecosystems. This project will achieve a process understanding and create predictive tools describing sediment resuspension and transport for use by industry and marine managers.Read moreRead less
Is transport of miRNAs essential for plant development? This project will provide knowledge of how a new class of biologically active molecule (micro RNA) regulates expression of genes at sites in the plant that are critical for growth and development. MicroRNAs are believed to influence the size and shape of plants, how rapidly they grow and how well they produce and fill seeds. These molecules are part of a group of bioactive signals that move throughout the plant, functioning like hormones bu ....Is transport of miRNAs essential for plant development? This project will provide knowledge of how a new class of biologically active molecule (micro RNA) regulates expression of genes at sites in the plant that are critical for growth and development. MicroRNAs are believed to influence the size and shape of plants, how rapidly they grow and how well they produce and fill seeds. These molecules are part of a group of bioactive signals that move throughout the plant, functioning like hormones but directly influencing how well critical genes work. Their exploitation holds great promise for manipulating plant performance and enhancing crop yields. Read moreRead less
CX3C chemokine signalling in the olfactory epithelium and its role in the self regeneration of the olfactory system. The current proposal will explore new venues in adult neural stem cell research and contribute to the further development of molecular biology and neuroscience research in Western Australia and Australia. The use of neural stem cells holds therapeutic promise for the treatment of a wide variety of neurological conditions, including neurotrauma and stroke. The proposed research wil ....CX3C chemokine signalling in the olfactory epithelium and its role in the self regeneration of the olfactory system. The current proposal will explore new venues in adult neural stem cell research and contribute to the further development of molecular biology and neuroscience research in Western Australia and Australia. The use of neural stem cells holds therapeutic promise for the treatment of a wide variety of neurological conditions, including neurotrauma and stroke. The proposed research will provide new data on the fundamental cellular and molecular events that are required to trigger the birth, differentiation and conditions for growth of new neurons in the adult nervous system. The generation of such insights will be critical for any translational research.
Read moreRead less
Hydrodynamics of Bubble Column Reactors. This project will study the hydrodynamics of bubble columns with the aim of optimising these reactors for offshore gas-to-liquid plants. Along with experiments using the state-of-art techniques such as the particle image velocimetry, radioactive particle tracking, electrical capacitance tomography and optical probes, computational fluid dynamics simulations will be conducted to gain a deeper insight into bubble-induced turbulence and regime transitions in ....Hydrodynamics of Bubble Column Reactors. This project will study the hydrodynamics of bubble columns with the aim of optimising these reactors for offshore gas-to-liquid plants. Along with experiments using the state-of-art techniques such as the particle image velocimetry, radioactive particle tracking, electrical capacitance tomography and optical probes, computational fluid dynamics simulations will be conducted to gain a deeper insight into bubble-induced turbulence and regime transitions in these reactors. This information will then be used to devise scale-up strategies of these complex and industrially important equipment.Read moreRead less
Fluid-Structure Interactions in Flows through Flexible-Walled Channels. This project seeks to deliver a definitive understanding of the behaviour of steady and pulsating fluid flow through compliant-walled channels and pipes. Novel theoretical stability-analyses and experimental investigations, complemented by targeted numerical simulations, will be developed and used to identify and categorise fluid- and wall-based wave-disturbances and their interactions. This can underpin the development of t ....Fluid-Structure Interactions in Flows through Flexible-Walled Channels. This project seeks to deliver a definitive understanding of the behaviour of steady and pulsating fluid flow through compliant-walled channels and pipes. Novel theoretical stability-analyses and experimental investigations, complemented by targeted numerical simulations, will be developed and used to identify and categorise fluid- and wall-based wave-disturbances and their interactions. This can underpin the development of technologies that control these flows to advantage in both engineered fluid-flow and biologically occurring systems. Robust design guidelines will emerge to safeguard and enhance the use of compliant liners and flexible panels for drag and noise reductions, or to protect surfaces exposed to fluid flows. Read moreRead less
Quantifying and parameterising ocean mixing. This project aims to advance our ability to describe the efficiency and intensity of ocean mixing. The project will develop and apply innovative techniques to estimate ocean mixing from both traditional ship-based, vertical-profiling turbulence measurements and from autonomous moorings. The project will undertake a re-analysis of historic measurements and obtain new measurements using autonomous systems. The results will be used to develop both a uni ....Quantifying and parameterising ocean mixing. This project aims to advance our ability to describe the efficiency and intensity of ocean mixing. The project will develop and apply innovative techniques to estimate ocean mixing from both traditional ship-based, vertical-profiling turbulence measurements and from autonomous moorings. The project will undertake a re-analysis of historic measurements and obtain new measurements using autonomous systems. The results will be used to develop both a universal relationship describing the efficiency of ocean mixing, and to quantify the underlying length scale controlling mixing intensity. This will enable the development of the next generation of turbulence closure models needed to describe ocean circulation and stirring.Read moreRead less