Phenotypic And Functional Characterisation Of CD4 T Helper 22 Cells And Their Role In The Regulation Of Chronic Allergic Disease Of The Lung And Skin
Funder
National Health and Medical Research Council
Funding Amount
$714,061.00
Summary
Allergic inflammatory diseases such as asthma and allergic dermatitis are major health problems in our community that lead to poor quality of life. These diseases are induced by activation of immune cells known as T helper (Th) lymphocytes. Recently Th22 cells have been identified in patients with allergic diseases. In this study we will, for the first time, characterise these cells and determine their role in the processes that lead to chronic inflammation in asthma and allergic dermatitis.
Understanding The Role Of Th22 Cells In Regulating Respiratory Immune Responses In Health And Disease.
Funder
National Health and Medical Research Council
Funding Amount
$870,476.00
Summary
T cells that produce the cytokine IL-22 (Th22 cells) are found in infectious and inflammatory lung disease. However, the role of Th22 cells in promoting or preventing disease remains largely unknown. We have discovered how to grow Th22 cells and have generated a unique strain of IL-22 reporter mice, which will allow us to identify their role in infectious and inflammatory diseases. Our investigations will provide new insights into therapeutic approaches for these diseases of the lung.
Anti-viral Immunity In Asthma: A Detailed Assessment Of TLR7 Function And The Regulation Of Interferon ?/? Synthesis.
Funder
National Health and Medical Research Council
Funding Amount
$517,156.00
Summary
Many people with asthma are unusually vulnerable to viral infections. This study will carefully examine different components of immune function in people with asthma, including the receptors that respond to viral nucleic acids and the reasons why people with asthma do not produce normal quantities of anti-viral interferons. This research may lead to novel methods for prevention and treatment of virus infections in people with asthma.