Magnetically controlled drug release from tissue scaffolds for the treatment of acute burns. Severe skin burns are frequently associated with functionally disabling scarring and the risk of death. New magnetically activated wound seals for the treatment of acute burns will be developed that reduce the need for frequent painful dressing changes and hence facilitate rapid healing with a significantly reduced chance of scarring.
Seeing without eyes: the evolution of non-visual photoreceptors in vertebrates. Australia's underwater biodiversity is second to none with endemic species representing the earliest stages in vertebrate evolution, many of them relying heavily on vision for survival. Tracing the evolution of light detection and image formation will provide crucial information about the lifestyles of our vertebrate ancestors, the environmental selection pressures driving speciation and colour communication. Charact ....Seeing without eyes: the evolution of non-visual photoreceptors in vertebrates. Australia's underwater biodiversity is second to none with endemic species representing the earliest stages in vertebrate evolution, many of them relying heavily on vision for survival. Tracing the evolution of light detection and image formation will provide crucial information about the lifestyles of our vertebrate ancestors, the environmental selection pressures driving speciation and colour communication. Characterisation of optimal light environments and extra-ocular light detection will also help protect and manage endemic species in wild and captive environments. Read moreRead less
Aquatic eye design: sharks and rays as models of underwater colour and luminance vision. Sharks are usually assumed to be colour blind. We have discovered that they may in fact see colour very well and that the eyes of different species are adapted to their particular lifestyles. Our research will help to raise the profile of sharks and portray them as animals with advanced sensory systems and complex visual behaviours rather than just dangerous killing machines. Studying the vision of sharks m ....Aquatic eye design: sharks and rays as models of underwater colour and luminance vision. Sharks are usually assumed to be colour blind. We have discovered that they may in fact see colour very well and that the eyes of different species are adapted to their particular lifestyles. Our research will help to raise the profile of sharks and portray them as animals with advanced sensory systems and complex visual behaviours rather than just dangerous killing machines. Studying the vision of sharks may also help to reduce the number (currently >50,000) that are killed each year as bycatch by Australian long-line fisheries and make a valuable contribution to one of Australia's National Research Priorities (an Environmentally Sustainable Australia) for managing and conserving our biodiversity.Read moreRead less
Effects of physical disturbance on kelp-dominated reef communities across a broad temperate-tropical transition zone. The outcomes of this project will improve the understanding of the interactions between physical disturbances, nutrient enrichment and climate change. This addresses the national research priority of an environmentally sustainable Australia (priority goals sustainable use of biodiversity and responding to climate changes) and will contribute directly to Australia's commitments on ....Effects of physical disturbance on kelp-dominated reef communities across a broad temperate-tropical transition zone. The outcomes of this project will improve the understanding of the interactions between physical disturbances, nutrient enrichment and climate change. This addresses the national research priority of an environmentally sustainable Australia (priority goals sustainable use of biodiversity and responding to climate changes) and will contribute directly to Australia's commitments on marine ecosystem management and conservation.Read moreRead less
Impact of increased sediment and nutrient discharges on the long-term sustainability of the Great Barrier Reef. The Great Barrier Reef, one of Australia's greatest natural assets, is under increasing threat from extreme climatic events caused by global warming and from land-based pollution. This research will identify the main sources of sediment and nutrient pollution caused by river runoff and by how much this has increased above 'natural levels'. We will discover how the very sensitive offsho ....Impact of increased sediment and nutrient discharges on the long-term sustainability of the Great Barrier Reef. The Great Barrier Reef, one of Australia's greatest natural assets, is under increasing threat from extreme climatic events caused by global warming and from land-based pollution. This research will identify the main sources of sediment and nutrient pollution caused by river runoff and by how much this has increased above 'natural levels'. We will discover how the very sensitive offshore coral reefs have responded to increased pollution and whether this is the cause of the very devastating crown-of-thorn-starfish infestations. Understanding the long-term effects of land-based pollution on the ecology of coral reefs in the GBR will thus provide a scientific basis to help ensure that it has a sustainable future.Read moreRead less
Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family protei ....Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family proteins as specific effectors. This project will address a new paradigm in genetics that is likely to underpin development.Read moreRead less