Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347955
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
A Cell Sorter Facility for Neuroscience and Related Biotechnology. Neuroscience is entering an era of accelerated discovery in which Queensland neuroscientists can excel if they gain leadership in key technologies. One critical technology is the ability to obtain specific cell populations from various parts of the nervous system in sufficient quantity and purity to enable their accurate examination by gene array, proteomics and physiological techniques. The aim is to establish the world's first ....A Cell Sorter Facility for Neuroscience and Related Biotechnology. Neuroscience is entering an era of accelerated discovery in which Queensland neuroscientists can excel if they gain leadership in key technologies. One critical technology is the ability to obtain specific cell populations from various parts of the nervous system in sufficient quantity and purity to enable their accurate examination by gene array, proteomics and physiological techniques. The aim is to establish the world's first cell-sorting facility dedicated to the production of nerve cells suitable for molecular characterization and screening, providing the basis for identifying key molecules regulating brain function, ageing and repair of great importance to the biotechnology/pharmaceutical industry.Read moreRead less
Inhibition of pro-inflammatory cytokine secretion- A new route to therapeutics of chronic inflammatory disease. Chronic inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease, affect millions of people leading to considerable suffering, economic loss and premature death. Anti-TNF treatments have recently shown success in the treatment of rheumatoid arthritis, inflammatory bowel disease and other conditions, however, a substantial number of patients (~50%) do not re ....Inhibition of pro-inflammatory cytokine secretion- A new route to therapeutics of chronic inflammatory disease. Chronic inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease, affect millions of people leading to considerable suffering, economic loss and premature death. Anti-TNF treatments have recently shown success in the treatment of rheumatoid arthritis, inflammatory bowel disease and other conditions, however, a substantial number of patients (~50%) do not respond to the current TNF treatments. Improved anti-TNF strategies would provide enhanced health outcomes and welcome relief to many Australians. In addition, the economic benefit of the TNF market is very substantial. Therefore the potential impact of this research is very high both for health care and economical potential.Read moreRead less
The molecular mechanism of retromer and sorting nexin function in endosomal membrane trafficking. The proposed research represents breakthrough science that will lead to a fundamental understanding at the molecular level of the structure and assembly of the retromer complex and how it regulates sorting of receptors in the endosomal system. It will provide excellent research training for top graduate students and post-doctoral scientists in multidisciplinary methods that constitute state-of the- ....The molecular mechanism of retromer and sorting nexin function in endosomal membrane trafficking. The proposed research represents breakthrough science that will lead to a fundamental understanding at the molecular level of the structure and assembly of the retromer complex and how it regulates sorting of receptors in the endosomal system. It will provide excellent research training for top graduate students and post-doctoral scientists in multidisciplinary methods that constitute state-of the-art structural and molecular cell biology research. By addressing an area of great interest internationally the project will have the capacity to increase Australia's knowledge base and strengthen it's reputation for research excellence.Read moreRead less
Endosomal Protein Transport: From Molecular Structures to Biological Function. Intracellular transport of biomolecules through the endosomal organelle is critical for normal cellular processes such as signalling, homoeostasis and development. Defects in this fundamental process and subversion of it by bacterial and viral pathogens also lead to many different human diseases. This project will build on Australia's strong programme of structural and cellular biology research to develop key insights ....Endosomal Protein Transport: From Molecular Structures to Biological Function. Intracellular transport of biomolecules through the endosomal organelle is critical for normal cellular processes such as signalling, homoeostasis and development. Defects in this fundamental process and subversion of it by bacterial and viral pathogens also lead to many different human diseases. This project will build on Australia's strong programme of structural and cellular biology research to develop key insights into endosomal trafficking at the molecular level. Outcomes from this work will place Australia at the forefront of international efforts to understand this essential biological process and will have important implications for future design of pharmaceuticals.Read moreRead less
Descartes' Ontology of Everyday Life. Australia has a strong international reputation in philosophy and the history of philosophy. This project will contribute to our standing in the international community of scholars and to the teaching of Australian students in the historical origins of contemporary ideas and problems. It will furthermore contribute to the growing recognition of early modern interdisciplinary studies within Australia by drawing on ideas from the history of science, early mode ....Descartes' Ontology of Everyday Life. Australia has a strong international reputation in philosophy and the history of philosophy. This project will contribute to our standing in the international community of scholars and to the teaching of Australian students in the historical origins of contemporary ideas and problems. It will furthermore contribute to the growing recognition of early modern interdisciplinary studies within Australia by drawing on ideas from the history of science, early modern philosophy, medieval philosophy and the history of early modern thought and ideas.Read moreRead less
The Baroque in Architectural Culture, 1880-1980. This project will show the significance of historical architecture in the present day, and lead to better understanding of the cultural role of building. It will enhance the reputation of Australian research on the architectural history of early modern Europe, and on issues of historical method. It will train emerging researchers and develop a research environment for further research on this field. The project will foster international connection ....The Baroque in Architectural Culture, 1880-1980. This project will show the significance of historical architecture in the present day, and lead to better understanding of the cultural role of building. It will enhance the reputation of Australian research on the architectural history of early modern Europe, and on issues of historical method. It will train emerging researchers and develop a research environment for further research on this field. The project will foster international connections and collaborations and support the publication of internationally relevant research.Read moreRead less
Science and Religion in Early Modern Europe. This project seeks to elucidate the nature of early modern science, early modern religion, and their relationship. A major focus will be the shift from medieval conceptions of science (scientia) and religion (religio) as inner virtues, to the modern understanding of science and religion as bodies of knowledge and sets of practices. This transformation was fundamental to the emergence of modern science and made possible a new kind of relationship be ....Science and Religion in Early Modern Europe. This project seeks to elucidate the nature of early modern science, early modern religion, and their relationship. A major focus will be the shift from medieval conceptions of science (scientia) and religion (religio) as inner virtues, to the modern understanding of science and religion as bodies of knowledge and sets of practices. This transformation was fundamental to the emergence of modern science and made possible a new kind of relationship between science and religion?one unique to the West. The project will enhance our understanding of the rise of science and identify distinctive features of modern Western culture.Read moreRead less
A unified theory of the individual - a central problem in analytical philosophy. This project will further increase Australia's already high profile in analytic philosophy. This will foster an intellectual environment within Australia that will attract highly skilled overseas academics who bring knowledge and funding to Australia, benefiting both Australian researchers and students. This will in turn attract overseas fee-paying students who bring economic and cultural benefits to Australia.
The logical and metaphysical challenge of vague language. Where do we draw the line between life and death, tall and short, right and wrong? The vagueness or indeterminacy of such concepts prohibits easy answers. This projects aims to provide a philosophical analysis of such concepts which abound in natural language with a view to showing that orthodox views in logic and metaphysics are challenged by their presence. This analysis is to be published as a monograph whose significance lies in the f ....The logical and metaphysical challenge of vague language. Where do we draw the line between life and death, tall and short, right and wrong? The vagueness or indeterminacy of such concepts prohibits easy answers. This projects aims to provide a philosophical analysis of such concepts which abound in natural language with a view to showing that orthodox views in logic and metaphysics are challenged by their presence. This analysis is to be published as a monograph whose significance lies in the fact that it provides one of only four book-length treatments of the matter and does so from an entirely novel perspective.Read moreRead less
Particle Transport and Separation in High Aspect Ratio Inclined Channels. This project will be of benefit to the Australian coal and mineral processing industries, worth tens of billions of dollars to the Australian economy each year. The objective is to establish new options for the processing of particles as large as 50mm, and smaller than 50 microns in size, and hence significantly extend the operating size range of the Reflux Classifier. The development of new resources, especially those of ....Particle Transport and Separation in High Aspect Ratio Inclined Channels. This project will be of benefit to the Australian coal and mineral processing industries, worth tens of billions of dollars to the Australian economy each year. The objective is to establish new options for the processing of particles as large as 50mm, and smaller than 50 microns in size, and hence significantly extend the operating size range of the Reflux Classifier. The development of new resources, especially those of poorer grade, requires more effective separation technology. Success in this project will significantly benefit the end users of the technology and also contribute to Australia's Mining Services industry.Read moreRead less