Determination of the mechanisms of immune system regulation of inflammation by the human protein, chaperonin 10. The aim of this project is to determine the mechanisms by which a human protein, chaperonin 10 (Cpn10), regulates the immune system and suppresses inflammation. When cells of the human immune system are challenged with lipopolysaccharide (LPS) (a product of bacterial infection), the pro-inflammatory cytokine TNF is released. Cpn10 has been shown to suppress production of TNF on chall ....Determination of the mechanisms of immune system regulation of inflammation by the human protein, chaperonin 10. The aim of this project is to determine the mechanisms by which a human protein, chaperonin 10 (Cpn10), regulates the immune system and suppresses inflammation. When cells of the human immune system are challenged with lipopolysaccharide (LPS) (a product of bacterial infection), the pro-inflammatory cytokine TNF is released. Cpn10 has been shown to suppress production of TNF on challenge of cells with LPS, while increasing the levels of the anti-inflammatory cytokine IL-10. Investigating the role of Cpn10 in modulating inflammation will contribute to the understanding and treatment of diseases associated with inflammation, including multiple sclerosis and rheumatoid arthritis.Read moreRead less
Targeted development of dual action antitumour and antiangiogenic agents using differential and functional proteomics. There is an enormous need to develop more effective and less toxic therapeutic approaches to reduce the social and economic burden of cancer. The recent identification of small molecules that can act by both destroying cancer cells and the blood vessels that carry nutrients to them has provided a unique opportunity to define the pathways involved in the action of these agents in ....Targeted development of dual action antitumour and antiangiogenic agents using differential and functional proteomics. There is an enormous need to develop more effective and less toxic therapeutic approaches to reduce the social and economic burden of cancer. The recent identification of small molecules that can act by both destroying cancer cells and the blood vessels that carry nutrients to them has provided a unique opportunity to define the pathways involved in the action of these agents in order to develop more potent drug analogues. Development of these molecules will involve a collaborative and multidisciplinary link with our industry partner and the use of frontier technologies that may lead to improved health and economic outcomes for Australia. Read moreRead less
Development of an active noise control system for sleeper seats on large commercial aircraft. Possible avenues will be investigated to actively reduce aircraft cabin noise experienced by passengers in sleeper seats, using localised active noise control (ANC). Previous work has focused on headsets and upright seat headrests which represent a different problem to the partially enclosed sleeper seats considered here. Efficiency and robustness problems that affect existing ANC systems will be addres ....Development of an active noise control system for sleeper seats on large commercial aircraft. Possible avenues will be investigated to actively reduce aircraft cabin noise experienced by passengers in sleeper seats, using localised active noise control (ANC). Previous work has focused on headsets and upright seat headrests which represent a different problem to the partially enclosed sleeper seats considered here. Efficiency and robustness problems that affect existing ANC systems will be addressed. A prototype system will be produced for a business class sleeper seat in a wide body aircraft. A second outcome is the establishment of a robust integrated system design procedure that can be used to quickly develop ANC systems for future designs.Read moreRead less
Scaling Up Satellite Communications for the Internet of Things. The Internet of Things (IoT) is a revolution in sensing and automation that is becoming vital for industries including farming and mining. However, in remote areas, it is especially challenging to connect the large numbers of devices needed. This project will develop novel signal processing and communications approaches to deliver high quality data services to vast numbers of remote IoT devices, distributed over continental scales c ....Scaling Up Satellite Communications for the Internet of Things. The Internet of Things (IoT) is a revolution in sensing and automation that is becoming vital for industries including farming and mining. However, in remote areas, it is especially challenging to connect the large numbers of devices needed. This project will develop novel signal processing and communications approaches to deliver high quality data services to vast numbers of remote IoT devices, distributed over continental scales connected via low earth orbit (LEO) satellite constellations. It will provide the tools for LEO satellite service providers to dimension their networks and assist IoT providers to scale their remote sensor networks and IoT deployments, with ever increasing demand on the limited satellite bandwidth.Read moreRead less
Automatic speech-based assessment of mental state via mobile device. This project aims to create the first mobile, device-based automatic assessment of mental state from acoustic speech. Focusing on novel approaches for eliciting speech, for regression-based scoring of mental state and for longitudinal modelling of speech, the project takes speech processing out of the laboratory and into realistic environments. The project is significant because elicitation approach and longitudinal modelling h ....Automatic speech-based assessment of mental state via mobile device. This project aims to create the first mobile, device-based automatic assessment of mental state from acoustic speech. Focusing on novel approaches for eliciting speech, for regression-based scoring of mental state and for longitudinal modelling of speech, the project takes speech processing out of the laboratory and into realistic environments. The project is significant because elicitation approach and longitudinal modelling have been acknowledged by the research community as challenges that are valuable to investigate, and because conventional regression methods are sub-optimal on ordinal mental state scales. This is significant commercially because mobile devices allow individually tailored, frequent and low-cost mental state assessment. Expected outcomes will include commercial-ready technology, trialled on Australians, accessible to everyone with a mobile device and concentration of Australian research and development capability in a rapidly growing application area.Read moreRead less
Protecting Critical Transport Infrastructure using Hybrid Approaches for Interference and Spoofer Detection and Localisation. Modern infrastructure increasingly relies on the positioning and timing capabilities provided by the Global Navigation Satellite Systems (GNSS). GNSS signals, however, are vulnerable to interference and spoofing attacks. This vulnerability is aggravated as satellite navigation becomes more central to the operation of airports, ports, railways, and communications systems. ....Protecting Critical Transport Infrastructure using Hybrid Approaches for Interference and Spoofer Detection and Localisation. Modern infrastructure increasingly relies on the positioning and timing capabilities provided by the Global Navigation Satellite Systems (GNSS). GNSS signals, however, are vulnerable to interference and spoofing attacks. This vulnerability is aggravated as satellite navigation becomes more central to the operation of airports, ports, railways, and communications systems. Building on from earlier work by University of New South Wales, University of Adelaide and GPSat Systems, this project aims to create a system for locating interference and spoofers to GNSS of any power in real time, providing layered monitoring and reactive mitigation solutions against interference and spoofing attacks.Read moreRead less
Design of Wireless sensor and communication networks with fixed and mobile nodes. Wireless sensor and communication networks with fixed and mobile nodes are rapidly becoming essential technologies for hostile environmental monitoring, battlefield surveillance and precision agriculture. However, due to the complexities associated with interconnected design issues involving sensors, autonomous vehicles and communication protocols, even very simple networks have proven to be difficult to design. Th ....Design of Wireless sensor and communication networks with fixed and mobile nodes. Wireless sensor and communication networks with fixed and mobile nodes are rapidly becoming essential technologies for hostile environmental monitoring, battlefield surveillance and precision agriculture. However, due to the complexities associated with interconnected design issues involving sensors, autonomous vehicles and communication protocols, even very simple networks have proven to be difficult to design. This project proposes to intelligently employ higher capabilities of mobile nodes and develop methods for rapid deployment, maintenance and routing that are aware of location, energy, and security. The outcomes of this project will form the basis for design of intelligent wireless networks for defence and civilian applications.Read moreRead less
Reliable bi-directional machine-type communications for smart agriculture. This project aims to develop innovative solutions for agricultural machine-type communications to provide robust and bi-directional coverage for remote agriculture areas with difficult terrain, by leveraging smart-sensor-enabled, energy-efficient uplink transmissions and ultra-reliable downlink transmissions. Machine-type communications have been recognised as a key enabler for the future smart agriculture and smart farms ....Reliable bi-directional machine-type communications for smart agriculture. This project aims to develop innovative solutions for agricultural machine-type communications to provide robust and bi-directional coverage for remote agriculture areas with difficult terrain, by leveraging smart-sensor-enabled, energy-efficient uplink transmissions and ultra-reliable downlink transmissions. Machine-type communications have been recognised as a key enabler for the future smart agriculture and smart farms. The project will use novel agricultural machine-type communication theories and develop test-beds to enable the smart agricultural applications. This is expected to contribute to the crucial communication infrastructures for smart farms, which will lead to higher agricultural productivity and national economy.Read moreRead less
Cancelling neighbouring voices for enhanced audio-visual collaboration. Cancelling neighbouring voices for enhanced audio-visual collaboration. This project aims to improve voice communication in immersive video conference technology for distance-based learning, using classrooms of students. research new theoretical approaches and develop new technology to transform the voice communication experience for co-located immersive video conferencing participants. When participants are co-located, two ....Cancelling neighbouring voices for enhanced audio-visual collaboration. Cancelling neighbouring voices for enhanced audio-visual collaboration. This project aims to improve voice communication in immersive video conference technology for distance-based learning, using classrooms of students. research new theoretical approaches and develop new technology to transform the voice communication experience for co-located immersive video conferencing participants. When participants are co-located, two major audio issues—significant acoustic echo and instability—can arise; these are barriers to the wider adoption of this mode of education delivery. The expected outcome is an immersive video conferencing application deployed by the partner organisation. A key benefit will be a significantly enhanced product that provides a commercial advantage as well as a solution to remote learning for Australian students and educators.Read moreRead less
New Methods and Microelectronics for Wireless Communication Systems. Global demand for high quality wireless communications poses significant challenges. The so-called "physical layer" is crucial, as this is where the vagaries of the wireless channel, including interference and limited bandwidth, are mitigated by sophisticated signal processing.
This project will conduct applied research to meet these physical layer challenges, providing solutions that feed directly into next generation wirel ....New Methods and Microelectronics for Wireless Communication Systems. Global demand for high quality wireless communications poses significant challenges. The so-called "physical layer" is crucial, as this is where the vagaries of the wireless channel, including interference and limited bandwidth, are mitigated by sophisticated signal processing.
This project will conduct applied research to meet these physical layer challenges, providing solutions that feed directly into next generation wireless communication systems.
Uniquely, this project focuses on the transfer of research from theoretical genesis, through to realisation of silicon integrated
circuit "chips". This will maximise both the impact of the research
and the potential for significant national economic benefits to accrue.Read moreRead less