The Role Of P75 Neurotrophin Receptor-mediated Neurodegeneration Of Basal Forebrain Cholinergic Neurons
Funder
National Health and Medical Research Council
Funding Amount
$320,803.00
Summary
Alzheimer’s disease is a progressive neurodegenerative disorder characterized by clinical symptoms of memory deficits and cognitive function. It remains unclear what causes Alzheimer’s disease, but loss of a specific population of brain cells that are critical to cognitive function is generally accepted as a key feature of this condition. The aim of this project is to understand the mechanisms by which this cell loss occurs and how this relates to the loss of brain function.
Characterization Ol A Novel Covalently Cross -linked Abeta Peptide Dimer And Its Role In Alzheimers Disease.
Funder
National Health and Medical Research Council
Funding Amount
$553,236.00
Summary
Currently there are limited therapeutic treatments and no cure for Alzheimer's disease (AD). The key protein causing AD is called Abeta. Abeta peptides form dityrosine cross-linked dimers (when 2 peptides join together) and this is thought to be responsible for killing brain cells in AD. Therefore, this proposal will determine the role of Abeta dimers in relation to killing brain cells and the progression of AD through analysis of their biological and biochemical properties.