Modulation of protein folding pathways: a new platform technology for molecular medicine. Misfolding of proteins is becoming recognised as a major cause of inherited disease. We propose to develop a chemical agent that will optimise the folding of alpha1-antitrypsin (AAT), misfolding of which gives rise to inheritable liver and lung disease. This agent will have potential application as a therapy for sufferers of AAT-misfolding disease and for improving the yield of AAT purified from human plasm ....Modulation of protein folding pathways: a new platform technology for molecular medicine. Misfolding of proteins is becoming recognised as a major cause of inherited disease. We propose to develop a chemical agent that will optimise the folding of alpha1-antitrypsin (AAT), misfolding of which gives rise to inheritable liver and lung disease. This agent will have potential application as a therapy for sufferers of AAT-misfolding disease and for improving the yield of AAT purified from human plasma, which is the current agent used to treat patients with AAT-misfolding disease.Read moreRead less
An Economical, Robust Alternative Braille Transcription Device. The Curtin University Brailler (CUB). Braille is an important language used by the blind to read and write and Braillers are needed for everyday communication. This justifies the development of a light weight, transportable unit that is accessible at all times. This project proposes a relatively inexpensive, light weight, reliable and easily maintained Braille transcription system. The significant aspects of the proposed brailler in ....An Economical, Robust Alternative Braille Transcription Device. The Curtin University Brailler (CUB). Braille is an important language used by the blind to read and write and Braillers are needed for everyday communication. This justifies the development of a light weight, transportable unit that is accessible at all times. This project proposes a relatively inexpensive, light weight, reliable and easily maintained Braille transcription system. The significant aspects of the proposed brailler include;
- An Electromagnetically compatable (EMC)12 Volt Power Supply allowing the common car battery as a backup power source.
- Use of modern plastics (PTFE) to reduce weight, maintenance and EMC standards.
- An embedded system for Forward and Back translation of literary Braille
- Protocol development and specification for USB keyboard and (standard) printer.Read moreRead less