Cross-Entropy Methods in Complex Biological Systems. The Cross-Entropy method provides a powerful new way to find superior solutions to complicated optimisation problems in biology, ranging from better design and implementation of medical treatments to an increased understanding of complex ecosystems.
Discovery Early Career Researcher Award - Grant ID: DE200101791
Funder
Australian Research Council
Funding Amount
$427,082.00
Summary
Mathematically optimal R&D for coral reef conservation. This project aims to develop mathematical methodologies for optimising Research & Development (R&D) of technologies that will secure complex and uncertain ecosystems into the future. Current conventional management approaches will not prevent the degradation of threatened ecosystems like the Great Barrier Reef, so new technologies are needed. The biggest challenge in choosing these technologies is the long delay between development and depl ....Mathematically optimal R&D for coral reef conservation. This project aims to develop mathematical methodologies for optimising Research & Development (R&D) of technologies that will secure complex and uncertain ecosystems into the future. Current conventional management approaches will not prevent the degradation of threatened ecosystems like the Great Barrier Reef, so new technologies are needed. The biggest challenge in choosing these technologies is the long delay between development and deployment, in which time ecosystem function may collapse and complex, dynamic ecological and social systems will change. The mathematical methods and theory developed will inform a Great Barrier Reef case study, and will be ready for rapid application to other ecosystems as the urgent need arises.Read moreRead less
Statistical Methods for Discovering Ribonucleic acids (RNAs) contributing to human diseases and phenotypes. Identifying the causative genetic factors involved in quantitative phenotypes and diseases is a major goal of biology in the 21st century and beyond. A crucial step towards this goal is identifying and classifying the functional non-protein-coding Ribonucleic acids (RNAs) encoded in the human genome. This project will make major contributions to international efforts in this area by identi ....Statistical Methods for Discovering Ribonucleic acids (RNAs) contributing to human diseases and phenotypes. Identifying the causative genetic factors involved in quantitative phenotypes and diseases is a major goal of biology in the 21st century and beyond. A crucial step towards this goal is identifying and classifying the functional non-protein-coding Ribonucleic acids (RNAs) encoded in the human genome. This project will make major contributions to international efforts in this area by identifying RNA molecules that contribute to quantitative phenotypes including susceptibility to disease. As such, it will directly benefit fundamental science via the discovery and classification of new molecules. Indirectly, it will lead to breakthroughs in biology, and consequently to major medical and pharmaceutical advances in the diagnosis and treatment of genetic disease.Read moreRead less