We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Locating LGBTIQ+ youth in the archive: Telling new stories for belonging. This project aims to produce the first study of LGBTIQ+ youth in Australia’s past and investigate what these histories mean to LGBTIQ+ youth today. We will generate new knowledge of Australian LGBTIQ+ history and links between historical knowledge and wellbeing in relation to LGBTIQ+ youth. Working with LGBTIQ+ youth we will also develop new archival storytelling techniques, theorising archives as ‘laboratories of belongin ....Locating LGBTIQ+ youth in the archive: Telling new stories for belonging. This project aims to produce the first study of LGBTIQ+ youth in Australia’s past and investigate what these histories mean to LGBTIQ+ youth today. We will generate new knowledge of Australian LGBTIQ+ history and links between historical knowledge and wellbeing in relation to LGBTIQ+ youth. Working with LGBTIQ+ youth we will also develop new archival storytelling techniques, theorising archives as ‘laboratories of belonging’. In doing so, the project forges links between cultural studies of storytelling, LGBTIQ+ youth studies and Australian history. Benefits include innovations in reparative historical methodologies, new resources for the GLAM, youth and education sectors and improvements in LGBTIQ+ youth wellbeing.Read moreRead less
International perspectives on the regulation of young people's user-generated content. This project will examine international regulatory strategies for explicit user-generated content and suggest ways in which academics, policy makers and globally networked content users can be brought into dialogue so as to generate better informed and more effective regulatory policies.
Discovering a ‘good read’: Pathways to reading for Australian teens. This project aims to support the school, library, and book industries to increase teenagers’ recreational reading. Matching the right book to the right reader is essential to increase young people’s motivation to read. Yet how cultural intermediaries should operate to best effect within the complex ecologies that shape young people’s text selection is unclear. The project expects to generate robust evidence on how teens discove ....Discovering a ‘good read’: Pathways to reading for Australian teens. This project aims to support the school, library, and book industries to increase teenagers’ recreational reading. Matching the right book to the right reader is essential to increase young people’s motivation to read. Yet how cultural intermediaries should operate to best effect within the complex ecologies that shape young people’s text selection is unclear. The project expects to generate robust evidence on how teens discover books and the cultural factors that influence their choices. Expected outcomes include strategies that libraries, schools, and the book industry can use to promote Australian content for young adults, and equip young people to participate more fully in the social and economic benefits of pleasure reading.Read moreRead less
War, Literary Culture and Masculinity in Romantic Period Britain, 1750-1850. The Romantic period represents a formative moment in the history of Australia and my reconsideration of Romantic culture and war has relevance for understanding this history. Australia's own experience of war first originated with the frontier wars of 1788-1838. My research into British Romantic military and naval war writing will provide key insights into the military culture that dominated this formative moment of Aus ....War, Literary Culture and Masculinity in Romantic Period Britain, 1750-1850. The Romantic period represents a formative moment in the history of Australia and my reconsideration of Romantic culture and war has relevance for understanding this history. Australia's own experience of war first originated with the frontier wars of 1788-1838. My research into British Romantic military and naval war writing will provide key insights into the military culture that dominated this formative moment of Australian military history. War has, more broadly, been pivotal in the formation of Australian nationhood and identity. My project will contribute to our understanding of the role of war in Australian culture by providing fresh insight into the historical role of war writing in constructing modern forms of identity.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180101609
Funder
Australian Research Council
Funding Amount
$392,315.00
Summary
Telling the whole story in one sentence. This project aims to produce a framework for analysis of the ultra-long sentences that occur in hundreds of languages and to investigate the processing of these sentences by adults and children. Anticipated outcomes are enhanced models of language structure, mental processing of language, and brain functions. Understanding of drastically-different sentence types in the world’s languages will further benefit foreign language learners, machine translators, ....Telling the whole story in one sentence. This project aims to produce a framework for analysis of the ultra-long sentences that occur in hundreds of languages and to investigate the processing of these sentences by adults and children. Anticipated outcomes are enhanced models of language structure, mental processing of language, and brain functions. Understanding of drastically-different sentence types in the world’s languages will further benefit foreign language learners, machine translators, and immigrants learning English.Read moreRead less
Reconnecting Warlpiri communities with cultural heritage materials. The projects aims to reconnect Warlpiri communities with past documentation and recordings of their cultural heritage. Centred in Yuendumu, the project expects to unpack the significance of past documentation of cultural heritage for present day Warlpiri people who live in vastly different social worlds from their forebears. Through collaborations with Warlpiri families, and Partner Organisation, Pintupi Anmatyerr Warlpiri (PAW) ....Reconnecting Warlpiri communities with cultural heritage materials. The projects aims to reconnect Warlpiri communities with past documentation and recordings of their cultural heritage. Centred in Yuendumu, the project expects to unpack the significance of past documentation of cultural heritage for present day Warlpiri people who live in vastly different social worlds from their forebears. Through collaborations with Warlpiri families, and Partner Organisation, Pintupi Anmatyerr Warlpiri (PAW) Media and Communications, the project will see the set up of activities to engage with these materials and the production of resources for use by future generations.Read moreRead less
Reconstructing Eastern Himalayan Histories: languages, plants, and people. This project combines linguistic and ethnographic fieldwork to produce documentations of Bhutan's East-Bodish (Tibeto-Burman) speaking peoples, with an ultimate aim to reconstruct the social history of this group. The linguistic fieldwork will focus on different semantic domains, including religion, agriculture, and ethnobotany and grammatical features as different lenses into the past. The anthropological research will b ....Reconstructing Eastern Himalayan Histories: languages, plants, and people. This project combines linguistic and ethnographic fieldwork to produce documentations of Bhutan's East-Bodish (Tibeto-Burman) speaking peoples, with an ultimate aim to reconstruct the social history of this group. The linguistic fieldwork will focus on different semantic domains, including religion, agriculture, and ethnobotany and grammatical features as different lenses into the past. The anthropological research will bring new ethnographic light in to supplement the linguistic picture of the past, including religious practices and social organisation. Situated squarely within the eastern Himalayas, this project will provide new and crucial insights into the prehistory of Asia.Read moreRead less
A NOVEL MOUSE MODEL TO INVESTIGATE THE MECHANISMS OF VIRUS-INDUCED ARTHRITIS
Funder
National Health and Medical Research Council
Funding Amount
$336,000.00
Summary
We have developed a novel animal model by which to study arthritic disease caused by insect-transmitted viruses known as arboviruses. The existence of this model and novel reagents provides an excellent opportunity to further explore the basic mechanisms of infectious disease in a complete functioning animal, rather than specific cultured cells. The study will use modern approaches in molecular and cellular biology to achieve this goal. The production by our immune systems of soluble mediators ( ....We have developed a novel animal model by which to study arthritic disease caused by insect-transmitted viruses known as arboviruses. The existence of this model and novel reagents provides an excellent opportunity to further explore the basic mechanisms of infectious disease in a complete functioning animal, rather than specific cultured cells. The study will use modern approaches in molecular and cellular biology to achieve this goal. The production by our immune systems of soluble mediators (cytokines-chemokines) and antibodies is an overwhelming positive aspect of our physiological response to infection by microbes. Protection from disease by these immune compounds can happen naturally, or the body's ability to produce these factors can be exploited to our benefit via the administration of vaccines. However, these factors can also be detrimental to the host contributing to severe disease. For instance, work performed almost 40 years ago showed for the first time that under particular conditions, antibodies against viruses can enhance infection, instead of inhibiting infection as normally seen. In the intervening years work by scientists all over the world has associated antibody-dependent enhancement (ADE) of infection to many types of viruses; ADE is even thought to be a risk factor to serious disease with dengue virus, and has been shown in vitro for the AIDS virus and Ebola virus. We have recently discovered a molecular mechanism which explains how antibody enhances viral infection in vitro. In studies on immune cells infected with Ross River Virus (RRV) we found that infection helped by antibody resulted in the specific disruption to the production of cellular chemicals which are toxic to viruses. Are these mechanisms of antibody-enhanced infection also found in animals? Will such mode of infection cause enhanced disease and tissue pathology (arthritis) in animals?Read moreRead less