The Role Of Stem-progenitor Cells In Regeneration Of Mouse Endometrium.
Funder
National Health and Medical Research Council
Funding Amount
$311,938.00
Summary
The endometrium (lining of the uterus) undergoes breakdown and re-growth each month as part of the menstrual cycle. This restorative process is not well understood. For the first time stem cells have been identified within human endometrium that are likely to be responsible for its remarkable regeneration. The aim of this project is to identify stem cells within the mouse endometrium, to use as a model to understand how the endometrium restores each month after menstruation.
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Central Neural Circuits Subserving Nutrient–activated Thermogenesis - The Basis Of Post Prandial Energy Expenditure
Funder
National Health and Medical Research Council
Funding Amount
$766,207.00
Summary
Studies of “energy burning” brown fat, including its importance in the determination of obesity in humans and the potential to increase its capacity by turning white fat into brown-like fat are currently foremost in obesity research. Here we study the detail of brain pathways that dictate brown fat activity after a meal resulting in the burning of ingested calories and reduction of body weight. The results will give us a better idea of how we can harness brown fat to combat obesity.
Projecting Difference: A History of the Practice and Politics of French Cinema since 1980. This cultural history project has dual aims. Firstly, it will examine how French cinema, as a narrative art, has since the late 20th century become a major vector for defining cultural identity (partially eclipsing the role traditionally occupied by literature). On the other hand, it will document and analyse the processes by which cinema practice - diverse and often fractiously critical of existing politi ....Projecting Difference: A History of the Practice and Politics of French Cinema since 1980. This cultural history project has dual aims. Firstly, it will examine how French cinema, as a narrative art, has since the late 20th century become a major vector for defining cultural identity (partially eclipsing the role traditionally occupied by literature). On the other hand, it will document and analyse the processes by which cinema practice - diverse and often fractiously critical of existing political structures - has become a central symbolic weapon in the French State's political defence of cultural autonomy and difference in a globalising world. The resulting synthesis will provide extensive new understanding of the dynamics of contemporary France.Read moreRead less
Central Neural Regulation Of Brown Fat Function – Glucose Sensing And CNS Pathways
Funder
National Health and Medical Research Council
Funding Amount
$761,942.00
Summary
Our research aims to identify how specific brain cells detect changes in glucose levels and how ageing and diet affect their function. We identified a subset of nerve cells that detect changes in glucose and the “hunger” hormone ghrelin, their ability to do so adapting with age and nutritional status. This project will investigate the potential of these nerve cells as targets for therapeutic and diet- intervention strategies to target obesity, diabetes and promote healthy ageing.
The global self: screening the history of human rights in the 20th century to the present. This project will research the history and theory of human rights as represented in film and new media. It will analyse the origins and development of human rights theory and document the changes in films about human rights in order to understand how we now conceptualise human rights in the twenty-first-century.
Consuming Celebrity: Female stardom and gay subcultural reception. This project explores the function of celebrity in modern culture through a detailed case study of gay subcultural receptions of female stardom. The female star or ?diva? has been an influential figure in gay subcultures since the nineteenth century where it has inspired significant and enduring productions of gay selfhood. The project explores the histories of gay ?diva worship? to analyse the role and uses of stardom in formati ....Consuming Celebrity: Female stardom and gay subcultural reception. This project explores the function of celebrity in modern culture through a detailed case study of gay subcultural receptions of female stardom. The female star or ?diva? has been an influential figure in gay subcultures since the nineteenth century where it has inspired significant and enduring productions of gay selfhood. The project explores the histories of gay ?diva worship? to analyse the role and uses of stardom in formations of cultural identity. Through scholarly publications, the study will make major contributions to our understanding of not only gay culture and history, but the significance of celebrity in modern cultural life.Read moreRead less
Improving Communication with Aboriginal English Speakers: A Study of cultural conceptualisations in Aboriginal English. The project will explore cultural conceptualisations in Aboriginal English. Often unfamiliarity with Aboriginal cultural conceptualisations on the part of non-Aboriginal people leads to miscommunication, disadvantaging Aboriginal speakers, especially in institutional contexts (for example, schoolrooms, courtrooms, Centrelink offices). The aim of this study is to alleviate such ....Improving Communication with Aboriginal English Speakers: A Study of cultural conceptualisations in Aboriginal English. The project will explore cultural conceptualisations in Aboriginal English. Often unfamiliarity with Aboriginal cultural conceptualisations on the part of non-Aboriginal people leads to miscommunication, disadvantaging Aboriginal speakers, especially in institutional contexts (for example, schoolrooms, courtrooms, Centrelink offices). The aim of this study is to alleviate such problems, and significantly advance Aboriginal English research, by exploring culturally constructed conceptualisations, in particularly cultural-conceptual metaphor, underlying the use of Aboriginal English, using the the analytical tools of Cultural Linguistics. The study will also make a significant contribution to the development of Cultural Linguistics. Read moreRead less
Locating LGBTIQ+ youth in the archive: Telling new stories for belonging. This project aims to produce the first study of LGBTIQ+ youth in Australia’s past and investigate what these histories mean to LGBTIQ+ youth today. We will generate new knowledge of Australian LGBTIQ+ history and links between historical knowledge and wellbeing in relation to LGBTIQ+ youth. Working with LGBTIQ+ youth we will also develop new archival storytelling techniques, theorising archives as ‘laboratories of belongin ....Locating LGBTIQ+ youth in the archive: Telling new stories for belonging. This project aims to produce the first study of LGBTIQ+ youth in Australia’s past and investigate what these histories mean to LGBTIQ+ youth today. We will generate new knowledge of Australian LGBTIQ+ history and links between historical knowledge and wellbeing in relation to LGBTIQ+ youth. Working with LGBTIQ+ youth we will also develop new archival storytelling techniques, theorising archives as ‘laboratories of belonging’. In doing so, the project forges links between cultural studies of storytelling, LGBTIQ+ youth studies and Australian history. Benefits include innovations in reparative historical methodologies, new resources for the GLAM, youth and education sectors and improvements in LGBTIQ+ youth wellbeing.Read moreRead less
Transforming Cultural Identity: Media flows between Australia and East Asia. By evaluating Australia's role in East Asian media circuits, this project aims to identify new industry and consumer trends. The rise of East Asian media industries, estimated to be worth US$120 billion and reaching at least 2 billion consumers, is changing Australian media culture. While East Asian media reach in to Australian audiences via new media, Australian media industries are reaching out to Asia via transnation ....Transforming Cultural Identity: Media flows between Australia and East Asia. By evaluating Australia's role in East Asian media circuits, this project aims to identify new industry and consumer trends. The rise of East Asian media industries, estimated to be worth US$120 billion and reaching at least 2 billion consumers, is changing Australian media culture. While East Asian media reach in to Australian audiences via new media, Australian media industries are reaching out to Asia via transnational co-productions. This project plans to examine these trends in media consumption and production to analyse impacts on the cultural identities of Australian audiences and media products. Through the innovative framework of minor transnationalism, it plans to produce a deeper understanding of the nation's relationship with its region.Read moreRead less