Cellular Cross-talk Between Liver Progenitor Cells And Hepatic Stellate Cells Is Required For Hepatic Fibrogenesis
Funder
National Health and Medical Research Council
Funding Amount
$618,517.00
Summary
Deloitte Access Economics data proposes the total economic burden of liver disease in Australia in 2012 was >$50 billion. This study will identify how the liver heals itself by inducing liver cell populations which interact to regenerate damaged liver tissue in chronic liver disease. This knowledge may lead to the development of novel therapeutic interventions for the treatment of liver scarring and liver cancer, and to assist in normal liver regeneration following chronic liver disease.
Role Of Hepatic Stellate Cell And Liver Progenitor Cell Interactions In The Regulation Of Wound Healing And Liver Regeneration
Funder
National Health and Medical Research Council
Funding Amount
$620,716.00
Summary
The liver has a remarkable capacity for regeneration following acute and chronic liver injury, however, the mechanisms which facilitate this wound healing are not understood. This project will examine the interactions between different liver cell populations, including hepatic stellate cells (liver fibroblasts) and liver progenitor cells (stem cells of the liver) and will determine which factors regulate inflammation, liver scarring and restitution of liver mass following chronic liver injury.
Composites for thermal expansion matched oxygen electrodes. This project aims to develop high performance composite oxygen electrodes by using both negative thermal expansion materials and electrolyte materials to tailor the thermal expansion and activities of the perovskite-based electrodes for use in reduced temperature solid oxide cells. Such composite electrodes will show highly matched thermal expansion with electrolyte without sacrificing high activity at reduced temperatures. This project ....Composites for thermal expansion matched oxygen electrodes. This project aims to develop high performance composite oxygen electrodes by using both negative thermal expansion materials and electrolyte materials to tailor the thermal expansion and activities of the perovskite-based electrodes for use in reduced temperature solid oxide cells. Such composite electrodes will show highly matched thermal expansion with electrolyte without sacrificing high activity at reduced temperatures. This project seeks to address an important practical issue in the operation of solid oxide power cells - thermal expansion compatibility, which causes poor efficiency outside a narrow temperature band.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100026
Funder
Australian Research Council
Funding Amount
$480,000.00
Summary
A surface characterisation facility. This surface characterisation facility will provide scientists with an understanding of material's surfaces and interfaces. This will lead to a range of new technologies and innovative solutions required to address the many resource and environmental challenges facing our planet now and in the future.
Oxide-based high temperature proton exchange membrane fuel cells. Proton exchange membrane fuel cells (PEMFCs) are one of the most efficient energy conversion technologies for producing electricity from fuels such as hydrogen and methanol. Current PEMFCs use precious metal catalysts, and the performance of liquid methanol fuel is disappointingly low due to the inability of polymer or hybrid membranes to operate at temperatures above 160-180 degrees centigrade. This work aims to develop an all ox ....Oxide-based high temperature proton exchange membrane fuel cells. Proton exchange membrane fuel cells (PEMFCs) are one of the most efficient energy conversion technologies for producing electricity from fuels such as hydrogen and methanol. Current PEMFCs use precious metal catalysts, and the performance of liquid methanol fuel is disappointingly low due to the inability of polymer or hybrid membranes to operate at temperatures above 160-180 degrees centigrade. This work aims to develop an all oxide-based PEMFC technology using a recently developed sintered and heteropolyacid functionalised mesoporous silica membrane. The utilisation of all-oxide-PEMFCs using non-precious metal catalysts is expected to significantly enhance the power density, reduce costs, and enhance the commercial viability of PEMFC technologies.Read moreRead less
Future Distribution Grids based on Reconfigurable Smart Microgrid Clusters. This aims of the project are to develop innovative paradigm shifting concepts in which power distributions grids will be self sufficient to look after themselves in the absence of power transmission infrastructure. It is expected that in future several renewable energy based distributed generators (DGs) will be dotted in power distribution systems. It is estimated that within another couple of decades sufficient number o ....Future Distribution Grids based on Reconfigurable Smart Microgrid Clusters. This aims of the project are to develop innovative paradigm shifting concepts in which power distributions grids will be self sufficient to look after themselves in the absence of power transmission infrastructure. It is expected that in future several renewable energy based distributed generators (DGs) will be dotted in power distribution systems. It is estimated that within another couple of decades sufficient number of DGs will be placed in networks so much so that they will be able to meet the load demand of domestic and commercial customers. Therefore the focus of this project is to find innovative approaches in which several microgrids, equipped with single-phase and three-phase DGs can work cohesively while supporting each other.Read moreRead less
New mesoporous materials for use in high temperature proton exchange fuel cell membranes. A novel high temperature proton exchange membrane based on heteropolyacid (HPA) functionalised mesoporous silica will be developed. This research into the fundamental materials science of novel proton exchange membranes is expected to impact significantly on the advancement and commercialisation of portable fuel cell devices.
Transition to Customer Response Driven Networks. The project seeks to develop an electrical network costing framework that appropriately rewards customers who act to reduce network stress. The solution to the existing explosion in distribution network costs is to develop customer-responsive solutions in demand management and use of storage. The aim of this project is to develop a framework for network costs that is driven by local congestion and which would reward customer-responsive solutions. ....Transition to Customer Response Driven Networks. The project seeks to develop an electrical network costing framework that appropriately rewards customers who act to reduce network stress. The solution to the existing explosion in distribution network costs is to develop customer-responsive solutions in demand management and use of storage. The aim of this project is to develop a framework for network costs that is driven by local congestion and which would reward customer-responsive solutions. The vision is that the aggregator would provide customers with communications/control equipment that would automate the changes in the responsiveness so that customer-generated load shifting would act to limit peaks.Read moreRead less
Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family protei ....Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family proteins as specific effectors. This project will address a new paradigm in genetics that is likely to underpin development.Read moreRead less
Transforming Microgrid to Virtual Power Plant –ICT Frameworks,Tools,Control. The project aims to enhance large scale renewable penetrations to national power grid by advancing control, optimization, and ancillary services of Virtual Power Plants (VPPs), considering different disruptive events including recent South Australian blackout. This project expects to create new control, frame communication architecture, develop plug and play type IoT enabled grid interfacing inverter, and optimize resou ....Transforming Microgrid to Virtual Power Plant –ICT Frameworks,Tools,Control. The project aims to enhance large scale renewable penetrations to national power grid by advancing control, optimization, and ancillary services of Virtual Power Plants (VPPs), considering different disruptive events including recent South Australian blackout. This project expects to create new control, frame communication architecture, develop plug and play type IoT enabled grid interfacing inverter, and optimize resource management for distributed VPPs. The anticipated benefits from this institutional level collaborations are that VPPs help in enhancing national power grid operations during normal and disruptive conditions when more renewables are connected and also secure benefits of consumers, prosumers, and grid operators.Read moreRead less