Inhibition of pro-inflammatory cytokine secretion- A new route to therapeutics of chronic inflammatory disease. Chronic inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease, affect millions of people leading to considerable suffering, economic loss and premature death. Anti-TNF treatments have recently shown success in the treatment of rheumatoid arthritis, inflammatory bowel disease and other conditions, however, a substantial number of patients (~50%) do not re ....Inhibition of pro-inflammatory cytokine secretion- A new route to therapeutics of chronic inflammatory disease. Chronic inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease, affect millions of people leading to considerable suffering, economic loss and premature death. Anti-TNF treatments have recently shown success in the treatment of rheumatoid arthritis, inflammatory bowel disease and other conditions, however, a substantial number of patients (~50%) do not respond to the current TNF treatments. Improved anti-TNF strategies would provide enhanced health outcomes and welcome relief to many Australians. In addition, the economic benefit of the TNF market is very substantial. Therefore the potential impact of this research is very high both for health care and economical potential.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0454172
Funder
Australian Research Council
Funding Amount
$314,127.00
Summary
Facility for Analysis of Thermal Decomposition of Solid Materials at High Pressures. This submission aims to establish an integrated facility for studying the kinetics of solid and gas-solid reactions at elevated temperatures and high pressures; a piece of infrastructure that is urgently needed in Australia. The facility will consist of a high-pressure thermal gravimetric analyser (TGA) able to operate at up to 5 MPa, which will be coupled to a mass spectrometer (MS) for identification and quan ....Facility for Analysis of Thermal Decomposition of Solid Materials at High Pressures. This submission aims to establish an integrated facility for studying the kinetics of solid and gas-solid reactions at elevated temperatures and high pressures; a piece of infrastructure that is urgently needed in Australia. The facility will consist of a high-pressure thermal gravimetric analyser (TGA) able to operate at up to 5 MPa, which will be coupled to a mass spectrometer (MS) for identification and quantification of gaseous reaction products. The facility constitutes unique and significant national research infrastructure for the simultaneous acquisition of mass loss kinetic measurements together with characterisation and quantification of emission rates of gaseous fragments generated in the reaction. As a major outcome, the facility will provide a means for consistent investigation of kinetics of elemental reactions occurring in solids, or on solid surfaces during pyrolysis and gasification processes at high pressure.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100001
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
An advanced thermogravimetric analysis system for world-leading research in clean energy, catalysis, material science and nanotechnology. Many chemical reactions occurring in solid materials during heating significantly affect the materials' stability, and subsequently affects the processes of production of clean energy, material synthesis, catalyst preparation, and nanotechnology. No equipment currently exists in Australia that will mitigate the wide range of conditions in such reactions in ma ....An advanced thermogravimetric analysis system for world-leading research in clean energy, catalysis, material science and nanotechnology. Many chemical reactions occurring in solid materials during heating significantly affect the materials' stability, and subsequently affects the processes of production of clean energy, material synthesis, catalyst preparation, and nanotechnology. No equipment currently exists in Australia that will mitigate the wide range of conditions in such reactions in materials processing. This situation impedes research progress in Australia, disadvantages Australian research students, and ultimately makes our research less competitive internationally. The establishment of the proposed apparatus will increase the competitiveness of Australian science and engineering, and contribute to the development of new Australian technologies that are important to the Australian economy and to environmental sustainability.Read moreRead less