Sugars and non-caloric sweeteners are detected in the gut via a common sensor, which may control sugar uptake into the blood. We showed this sensor was defective in type 2 diabetic patients, which could worsen their disease. We will test if high intake of non-caloric sweeteners worsens gut control of blood glucose in healthy volunteers, and if a blocker of this sensor improves control in patients. Deep testing of this sensor will then be used to identify new drugs for managing type 2 diabetes.