Testing A Combination Of 2 Clinical Drugs, An IAP Inhibitor And P38 Inhibitor, To Treat AML
Funder
National Health and Medical Research Council
Funding Amount
$200,890.00
Summary
Current treatments only cure 50% of Acute Myeloid Leukaemia (AML) patients, and novel approaches to treatment are desperately needed to improve survival of patients with leukaemia. One new drug, Birinapant, is currently being tested in clinical trials to treat AML. I have found that some AMLs are resistant to Birinapant treatment but the addition of a second drug (called “p38 inhibitors”) can now overcome this resistance. I will test how effective combining these two drugs can be to treat AML.
The Value Of Providing Health Interventions For Heroin Use: A Cost Benefit Analysis
Funder
National Health and Medical Research Council
Funding Amount
$599,585.00
Summary
Heroin use and associated harms can be reduced through effective treatment. Past research has shown that treatment for heroin dependence can be relatively cost-effective, but not whether heroin treatment overall is a good investment. This unique study will estimate the net social benefit of heroin treatment, taking into account health, crime and family consequences. The results will help Australia respond better to this devastating health problem.
First-Line Management Of Youth Depression: A Randomised Placebo-Controlled Trial Of Fluoxetine And Cognitive Behavioural Therapy
Funder
National Health and Medical Research Council
Funding Amount
$1,316,648.00
Summary
The study aims to establish how to best treat adolescents and young adults when they present to mental health clinics with moderate-to-severe depression. There is, at present, considerable uncertainty as to whether young people should be started on antidepressant treatment at the same time as psychotherapy, or whether psychotherapy alone be commenced first. The study aims to clarify this important issue by implementing a trial that compares both treatment approaches.
Multi-centre, Multi-disciplinary Study Using A Systems Biology Approach To Investigate Immunomodulation In Children With Acute Wheeze
Funder
National Health and Medical Research Council
Funding Amount
$1,895,107.00
Summary
The concept that immunomodulation using naturally-occurring bacterial agents can treat asthma has reached international prominence. This is backed by strong epidemiologic and clinical trial data. However, detailed knowledge of the immunological mechanisms involved is essential to allow more focused therapeutic agents to be developed. The proposed multi-disciplinary immunomodulation study in 200 children aims to provide this essential information using an advanced systems biology approach.
Improving The Phenotypic Severity Of Intellectual Disability And Seizures Caused By Expanded Polyalanine Tract Mutations In The ARX Homeobox Transcription Factor.
Funder
National Health and Medical Research Council
Funding Amount
$683,622.00
Summary
Intellectual disability is frequent in the population, with as many as 1 in every 50 people in the world directly affected. ARX is a gene mutated in X chromosome-linked intellectual disability and seizures. Our study will comprehensively address the basis for improvements to disease outcomes following treatment with steriod horomones in mice modelling these mutations. We will also address the mechanism contributing to disturbed protein function due to these expanded polyalanine tract mutations.
Cannabidiol (CBD): A Novel Therapeutic For Alzheimer's Disease.
Funder
National Health and Medical Research Council
Funding Amount
$775,005.00
Summary
Current drugs do not stop or reverse the progression of Alzheimer’s disease (AD). Also, brains of AD patients show a number of biological changes and effective drugs should target those together. Cannabidiol (CBD) has such abilities when tested in AD cell models. We found that CBD can also prevent and reverse memory deficits in AD mice. We propose to provide convincing preclinical evidence for the benefits of CBD for human AD therapy and to define mechanisms involved.
Investigation Of The Effectiveness Of Group Cognitive Behavioural Therapy For Comorbid Anxiety And Depression In Older Adults
Funder
National Health and Medical Research Council
Funding Amount
$514,560.00
Summary
This project examines the effectiveness of group cognitive behaviour therapy for the treatment of co-existing anxiety and depression in older adults. This project is unique because research to date has only focused on treatment of depression or anxiety, despite large overlap of these disorders and evidence that the co-existence of these disorders is associated with worse outcomes such as increased risk for dementia, more severe depression and suicide.
Comparative Effectiveness Of Ultrasound-guided Injection With Either Autologous Platelet Rich Plasma Or Glucocorticoid For Ultrasound-proven Lateral Epicondylitis: A Three-arm Randomised Placebo-controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$518,631.00
Summary
Tennis elbow is a common condition affecting both men and women. It causes pain, disability, often inability to work and high health costs. The best treatment is uncertain but injection of a small quantity of a person’s own platelet rich plasma (PRP) appears to be a promising new treatment that has not yet been properly tested. We will perform a randomised, controlled trial to determine the efficacy, safety and cost-effectiveness of PRP injection to see if it is better than either placebo or cor ....Tennis elbow is a common condition affecting both men and women. It causes pain, disability, often inability to work and high health costs. The best treatment is uncertain but injection of a small quantity of a person’s own platelet rich plasma (PRP) appears to be a promising new treatment that has not yet been properly tested. We will perform a randomised, controlled trial to determine the efficacy, safety and cost-effectiveness of PRP injection to see if it is better than either placebo or corticosteroid injection.Read moreRead less
Increasing Access To Effective Psychological Treatment For Australians With Chronic Physical Disease.
Funder
National Health and Medical Research Council
Funding Amount
$605,627.00
Summary
Chronic physical diseases have a profound impact on Australian lives. The rates of anxiety and depression among Australians with chronic physical diseases are very high. However, less than 1 in 5 access any mental health treatment and, of those, less than 1 in 2 receive an effective psychological treatment. This project combines two significant innovations with the goal of increasing access to effective mental health treatment for Australians with chronic physical disease.
A Randomised Controlled Trial To Examine The Effectiveness Of Oxytocin To Improve Treatment For Anorexia Nervosa
Funder
National Health and Medical Research Council
Funding Amount
$415,854.00
Summary
Anorexia nervosa (AN) is a major public health problem. Nutritional rehabilitation programs exist but can be costly and protracted, and patients struggle to engage with these demanding therapies. The purpose of this study is to determine the efficacy of oxytocin nasal spray to improve outcomes in patients with AN participating in a nutritional rehabilitation program using a randomized placebo-controlled design. If shown to be effective, this will have national and international significance.