Multifunctional and Multimodal Theranostics: Manipulating Material Properties for Advanced Diagnostics. The utilisation of polymers in nanomedicine requires a bottom-up approach, where the fundamental chemistry is well-established and understood before it enables an application. This project develops branched polymers as new nanomaterials for theranostics; imaging modalities that “switch-on” when miRNA is released will quantify how much nanomaterial gets to a specific site, while a built-in sens ....Multifunctional and Multimodal Theranostics: Manipulating Material Properties for Advanced Diagnostics. The utilisation of polymers in nanomedicine requires a bottom-up approach, where the fundamental chemistry is well-established and understood before it enables an application. This project develops branched polymers as new nanomaterials for theranostics; imaging modalities that “switch-on” when miRNA is released will quantify how much nanomaterial gets to a specific site, while a built-in sensor based on physical changes in the nanomaterial will measure the onset and progression of necrosis. The aim is to develop a fundamental understanding of how polymer architecture and functionality can be utilised to drive device performance, providing a platform to probe new technology and methodologies for development of next generation theranostics.Read moreRead less
High performance inks for solution based organic light emitting diodes manufacturing. This project aims to introduce an advanced solution processing and printing technique for organic light emitting diode (OLED) fabrication based on a set of innovative macromolecular chemistries. These proceed either photochemically or thermally, exploiting precision macromolecular designs of the polymer precursor materials, which contain advanced emitter systems developed by Cynora. Solution fabrication of OLED ....High performance inks for solution based organic light emitting diodes manufacturing. This project aims to introduce an advanced solution processing and printing technique for organic light emitting diode (OLED) fabrication based on a set of innovative macromolecular chemistries. These proceed either photochemically or thermally, exploiting precision macromolecular designs of the polymer precursor materials, which contain advanced emitter systems developed by Cynora. Solution fabrication of OLED is a challenging, yet ultimately powerful, process with key advantages over current vacuum processing systems, especially with regard to production flexibility, cost and OLED size. The project will provide a functioning technology platform for solution OLED fabrication.Read moreRead less
Nitroxide-containing scaffolds for controlling biofilm-related infections. Bacterial biofilms are a major problem in healthcare systems around the world as they cause persistent and chronic infections, including those associated with medical implants and cystic fibrosis. This project aims to develop new chemical approaches to deliver nitroxides at surface interfaces and in microparticles to facilitate long term control over biofilm growth. It is expected that these functionalised scaffolds will ....Nitroxide-containing scaffolds for controlling biofilm-related infections. Bacterial biofilms are a major problem in healthcare systems around the world as they cause persistent and chronic infections, including those associated with medical implants and cystic fibrosis. This project aims to develop new chemical approaches to deliver nitroxides at surface interfaces and in microparticles to facilitate long term control over biofilm growth. It is expected that these functionalised scaffolds will represent a breakthrough in the field and will have a profound impact by reducing infection rates associated with medical devices and improving airway clearance in cystic fibrosis patients.Read moreRead less
Smart magnetic resonance imaging (MRI) contrast agents: from early detection to assessment of drug delivery mechanisms. 'Smart' contrast agents will be developed for enhancing the performance of magnetic resonance imaging (MRI) of diseases such as cancer by designing them to be triggered by biochemical markers for disease. This has the potential to aid in early detection which can lead to lower mortality rates and consequently a lower burden on the health system.
Traceable theranostics: tools for visualising drug delivery and therapeutic benefit in vivo. Forty-three thousand people died from cancer in Australia in 2010. The aim of this project is to advance the concept of 'personalised-therapy' through the development of novel imaging devices based on polymers that can 'switch-on' and deliver drugs in specific tissues, allowing more sensitive and earlier detection and monitoring of diseases and therapies.
Photoreactive Block copolymers: Controlling the Nanostructure of Materials with Light. The performance of future generations of computer chips, hard drives, batteries and membranes will be reliant on the ability to intimately control the nanostructure of materials. Although significant advances have been made in recent years, there still remains enormous scope to address challenges in nanofabrication of devices. Using rational design this project will develop materials whose nanostructure can be ....Photoreactive Block copolymers: Controlling the Nanostructure of Materials with Light. The performance of future generations of computer chips, hard drives, batteries and membranes will be reliant on the ability to intimately control the nanostructure of materials. Although significant advances have been made in recent years, there still remains enormous scope to address challenges in nanofabrication of devices. Using rational design this project will develop materials whose nanostructure can be controlled with light. This will allow spatial control of nanostructure, as well as access to novel materials and nanostructures. Understanding the relationships between nanostructure and performance will help guide the design of next generation devices. Read moreRead less
Dyes and Pigments as Building Blocks for Novel High Performance Organic Semiconductors. Natural dyes and pigments are well known for their bright colours, photochemical and thermal stability, and cheap cost. Recently, the necessity of high performing materials in the organic electronics has stimulated a renaissance of these historical molecules and their subsequent derivatives into new families of ?-conjugated building blocks used to construct new donor-acceptor semiconductors. The aim of this p ....Dyes and Pigments as Building Blocks for Novel High Performance Organic Semiconductors. Natural dyes and pigments are well known for their bright colours, photochemical and thermal stability, and cheap cost. Recently, the necessity of high performing materials in the organic electronics has stimulated a renaissance of these historical molecules and their subsequent derivatives into new families of ?-conjugated building blocks used to construct new donor-acceptor semiconductors. The aim of this project is to explore various novel dyes, pigments and their derivatives for constructing outstanding materials for future organic electronics.Read moreRead less
The crucial role of organic-inorganic interfaces in the performance of organic optoelectronic devices. Organic electronic devices such as organic light emitting diodes and organic solar cells are expected to lead to substantial benefits over conventional electronic components. However, there is increasing evidence that the interface between the organic layers and the inorganic electrodes (or active components in hybrid devices) could be sub-optimal in terms of critical properties such as electro ....The crucial role of organic-inorganic interfaces in the performance of organic optoelectronic devices. Organic electronic devices such as organic light emitting diodes and organic solar cells are expected to lead to substantial benefits over conventional electronic components. However, there is increasing evidence that the interface between the organic layers and the inorganic electrodes (or active components in hybrid devices) could be sub-optimal in terms of critical properties such as electron transfer and stability. The aim of this project is to understand the structure and properties of such interfaces and to probe their behaviour at elevated temperatures. The results will pave the way for organic electronic devices to become a commercial reality.Read moreRead less
Next generation high sensitivity polymeric Extreme Ultraviolet (EUV) resists. Each generation of computer we purchase has faster processors, larger memory and is smaller and cheaper than the preceding model. However the annual improvements are at risk due to inherent problems with existing technologies, so in this project we will produce technologies that will enable the next generation of energy-efficient, faster computers.
Diffusion – the key to performance in organic optoelectronic devices. In the future, new types of displays, solar cells and sensors for explosives based on organic materials will be common. This project will provide understanding and control of the movement of molecules between the layers that make up these devices leading to optimised performance and durability.