A gold-coated magnetic nanoparticle biosensor for detecting microRNA. The project aims to develop a biosensor for detecting short sequences of RNA, called microRNA (miRNA) in blood. There are about 100 miRNA sequences that are involved in most biological processes. Changes in the levels of some miRNA sequences can serve as a biomarker for many diseases including cancers. The miRNA will be detected using gold-coated magnetic nanoparticles modified with DNA sequences complementary to the miRNA of ....A gold-coated magnetic nanoparticle biosensor for detecting microRNA. The project aims to develop a biosensor for detecting short sequences of RNA, called microRNA (miRNA) in blood. There are about 100 miRNA sequences that are involved in most biological processes. Changes in the levels of some miRNA sequences can serve as a biomarker for many diseases including cancers. The miRNA will be detected using gold-coated magnetic nanoparticles modified with DNA sequences complementary to the miRNA of interest to capture the miRNA. Application of a magnetic field allows the levels of miRNA to be detected electrochemically. The expected outcome is a commercialisable biosensor for miRNA both as a diagnostic early detection device and a prognostic device for a range of miRNA biomarkers.Read moreRead less
Radio-magnetic nanoparticles as bimodal positron emission tomography/magnetic resonance imaging contrast agents for dendritic cell tracking. Biomedical imaging is limited by a lack of commercial dual-mode contrast agents, which may be simultaneously used for magnetic resonance (MR) and positron emission tomography (PET) imaging. This project will develop a nanotechnology-based biocompatible dual-mode contrast agent for simultaneous PET and MR imaging, reducing associated side effects.
New strategies for characterising and monitoring protein-surface interactions: application to a biosensor for diabetic’s blood glucose regime effectiveness. This project aims to develop an antibody based biosensor for the detection of glycosylated haemoglobin (HbA1c) which serves as a marker of the effectiveness of a diabetic’s blood glucose treatment regime. Monitoring HbA1c is important as many of the long term health effects of diabetes are a consequence of high blood glucose levels. The si ....New strategies for characterising and monitoring protein-surface interactions: application to a biosensor for diabetic’s blood glucose regime effectiveness. This project aims to develop an antibody based biosensor for the detection of glycosylated haemoglobin (HbA1c) which serves as a marker of the effectiveness of a diabetic’s blood glucose treatment regime. Monitoring HbA1c is important as many of the long term health effects of diabetes are a consequence of high blood glucose levels. The simple to use technology will be a general detection strategy for proteins and hence will be applicable for the detection of a wide range of diseases and biomarkers. The research will also benefit Australia by training the new generation of scientists for Australia's biomedical diagnostics industry.Read moreRead less
High performance, optimized chip-scale packaging for millimetre wave and THz integrated circuits. This project aims to revolutionise electronic packaging by depositing a thin, protective layer of diamond on top of high-performance, millimetre-wave and THz integrated circuits. Leveraging existing technology for removing heat from high-powered optical electronics, the project aims to deliver a miniaturised packaged chip, protected from the environment and ready for mounting in a system, without se ....High performance, optimized chip-scale packaging for millimetre wave and THz integrated circuits. This project aims to revolutionise electronic packaging by depositing a thin, protective layer of diamond on top of high-performance, millimetre-wave and THz integrated circuits. Leveraging existing technology for removing heat from high-powered optical electronics, the project aims to deliver a miniaturised packaged chip, protected from the environment and ready for mounting in a system, without seriously degrading the circuit's performance as occurs in current packaging technologies. The project aims to enable cheaper and more energy-efficient applications as wide ranging as wireless HD video, multi-gigabit telecommunications, and black-body passive imaging technologies for security, defence, medical and agricultural applications.Read moreRead less
A new technique for the assessment of burns. This international, interdisciplinary collaborative project should change the way skin burns are assessed with a broad impact on biotechnology, healthcare and non destructive testing. This project will build on Australia's position as a leader in terahertz technology with significant potential for commercialisation.