SEARCH - Study Of Environment On Aboriginal Resilience And Child Health
Funder
National Health and Medical Research Council
Funding Amount
$2,114,618.00
Summary
The SEARCH program of research investigates the relationship between environmental determinants of health in a cohort study with five year follow up involving 800 urban NSW Aboriginal families with approximately 2000 children aged 0-17. A subset of 480 families will be recruited to participate in a randomised controlled trial of the impact of a health broker on (i) improving treatment of otitis media, and (ii) a feasibility study of an intervention to improve housing in 50 households. These two ....The SEARCH program of research investigates the relationship between environmental determinants of health in a cohort study with five year follow up involving 800 urban NSW Aboriginal families with approximately 2000 children aged 0-17. A subset of 480 families will be recruited to participate in a randomised controlled trial of the impact of a health broker on (i) improving treatment of otitis media, and (ii) a feasibility study of an intervention to improve housing in 50 households. These two studies will form the basis of an urban Aboriginal cohort study spanning 20 years with funding from alternate sources.Read moreRead less
Osteoporosis is a common condition in which bone strength is reduced due to reduced amount and quality of bone. Reduced bone strength means an increased risk of fracture. Osteoporotic fractures occur in 1 in 2 women and 1 in 3 men in their lifetime, and the likelihood of suffering osteoporotic fracture increases with age. Most of the risk of developing osteoporosis is genetic, but few of the genes involved have been identified. Our goal is to identify those genes. We will complete recruitment an ....Osteoporosis is a common condition in which bone strength is reduced due to reduced amount and quality of bone. Reduced bone strength means an increased risk of fracture. Osteoporotic fractures occur in 1 in 2 women and 1 in 3 men in their lifetime, and the likelihood of suffering osteoporotic fracture increases with age. Most of the risk of developing osteoporosis is genetic, but few of the genes involved have been identified. Our goal is to identify those genes. We will complete recruitment and assessment of a cohort of 1500 postmenopausal women with either low or high bone mineral density from pre-existing population cohorts in Australia. A genomewide association study will then be performed on these cases. Associated genes in different datasets will then be investigated further in our cohort, and high-density SNP mapping performed to identify true associated variants. These studies should identify most genetic variants associated with BMD variation and low trauma fracture in the general community, allowing development of diagnostic-disease predictive genetic tests, and informing development of novel therapeutic agents for osteoporosis.Read moreRead less