ARC Centre of Excellence in Quantum Biotechnology. ARC Centre of Excellence in Quantum Biotechnology. The ARC Centre of Excellence in Quantum Biotechnology aims to develop paradigm-shifting quantum technologies to observe biological processes and transform our understanding of life. It seeks to create technologies that go far beyond what is possible today, from portable brain imagers to super-fast single protein sensors, and to use them to unravel key problems including how enzymes catalyse reac ....ARC Centre of Excellence in Quantum Biotechnology. ARC Centre of Excellence in Quantum Biotechnology. The ARC Centre of Excellence in Quantum Biotechnology aims to develop paradigm-shifting quantum technologies to observe biological processes and transform our understanding of life. It seeks to create technologies that go far beyond what is possible today, from portable brain imagers to super-fast single protein sensors, and to use them to unravel key problems including how enzymes catalyse reactions and how higher brain function emerges from networks of neurons. By building a diverse, multidisciplinary, and industry-engaged ecosystem, the Centre means to develop our future leaders at the interface of quantum science and biology and drive Australian innovation across manufacturing, energy, agriculture, health, and national security.Read moreRead less
Role of water in earth and planetary evolution. This project aims to understand the role of water in the building of our solar system, Mars and Earth. Surprisingly little is known about key issues surrounding the origin of water and its subsequent recycling on Earth. This project will use new techniques for measuring low abundances of water along with oxygen isotopes, to measure water abundances and oxygen isotopes in meteorites and terrestrial rocks to establish how water was delivered to Earth ....Role of water in earth and planetary evolution. This project aims to understand the role of water in the building of our solar system, Mars and Earth. Surprisingly little is known about key issues surrounding the origin of water and its subsequent recycling on Earth. This project will use new techniques for measuring low abundances of water along with oxygen isotopes, to measure water abundances and oxygen isotopes in meteorites and terrestrial rocks to establish how water was delivered to Earth and to understand how water is geologically recycled. This is expected to have direct bearing on where and how Earth's water originated, how water is retained in mantle and crustal minerals and it will have broad implications for understanding volcanic hazards and formation of ore deposits. This will lead to a new capability for combined water and oxygen isotope analysis in Australian geoscience leading to technological development and commercialisation of instrumentation.Read moreRead less
Laser-free on-chip super-resolution microscopy. The project aims to develop a compact, cost-effective on-chip super-resolution microscope through an innovative combination of imaging algorithms, optics and integrated photonics. This project addresses limitations in imaging algorithms that increase laser system complexity and constrain imaging speed and applications, as well as nanostructure fabrication issues. Expected outcomes include the discovery of emitter self-interference microscopy, new k ....Laser-free on-chip super-resolution microscopy. The project aims to develop a compact, cost-effective on-chip super-resolution microscope through an innovative combination of imaging algorithms, optics and integrated photonics. This project addresses limitations in imaging algorithms that increase laser system complexity and constrain imaging speed and applications, as well as nanostructure fabrication issues. Expected outcomes include the discovery of emitter self-interference microscopy, new knowledge in imaging, photonics and biophysics, the world’s fastest super-resolution technology, compact on-chip nanoscopy that can be added to existing technology and proof of concept in three areas. Benefits are anticipated in commercialisation, improved photonics devices and usage in biophysics.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100079
Funder
Australian Research Council
Funding Amount
$411,918.00
Summary
Anisotropic single-particle transducers. The project aims to tackle a major challenge in techniques that manipulate tiny particles – increasing the performance of transducer devices that convert magnetic forces to mechanical movement. It will centre on interactions on the surface of particular particles, bypassing a known scientific limit. Expected outcomes include a fundamental understanding of key factors that have recently been shown to enhance magnetic responsivity and efficient mechanical m ....Anisotropic single-particle transducers. The project aims to tackle a major challenge in techniques that manipulate tiny particles – increasing the performance of transducer devices that convert magnetic forces to mechanical movement. It will centre on interactions on the surface of particular particles, bypassing a known scientific limit. Expected outcomes include a fundamental understanding of key factors that have recently been shown to enhance magnetic responsivity and efficient mechanical manipulation and sensing in a magnetic field. The project outcomes will benefit developers by, for example, advanced nanoscale devices for robotics, sensing and molecular bioassays; controlling biophysical processes; and fundamental mechanobiology research.Read moreRead less
Designing a spectrometer to search for life on extrasolar planets. Finding indicators of life on extrasolar planets is one of the greatest science questions of our time. Astronomers have found rocky, earth-like exoplanets; now we need powerful spectrometers to search for biomarkers in their atmospheres, detecting the faint imprints from molecules associated with life in the colour spectrum of stars. This project will develop the instruments and technologies required to enable spectroscopy with m ....Designing a spectrometer to search for life on extrasolar planets. Finding indicators of life on extrasolar planets is one of the greatest science questions of our time. Astronomers have found rocky, earth-like exoplanets; now we need powerful spectrometers to search for biomarkers in their atmospheres, detecting the faint imprints from molecules associated with life in the colour spectrum of stars. This project will develop the instruments and technologies required to enable spectroscopy with massively multiplexed telescopes. A spectrometer design with large spectral bandwidth and high resolution, optimised for a facility consisting of thousands of small telescopes, and novel optical fibres to link them, will open the door for breakthrough science requiring an entirely new class of telescope.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230101128
Funder
Australian Research Council
Funding Amount
$444,154.00
Summary
Decode Neuro-Mechanobiology:mechanosensitive ion channels in proprioception. Human bodies are densely covered with numerous mechanosensory neurons that provide us with the sense of touch and pain. However, the molecular force sensors remain poorly identified. This project aims at defining the fundamental roles of mechanosensitive ion channels to sense and respond to various mechanical stimuli, and how their responses may encode mechanical cues.The ultimate goal is to provide a fundamentally new ....Decode Neuro-Mechanobiology:mechanosensitive ion channels in proprioception. Human bodies are densely covered with numerous mechanosensory neurons that provide us with the sense of touch and pain. However, the molecular force sensors remain poorly identified. This project aims at defining the fundamental roles of mechanosensitive ion channels to sense and respond to various mechanical stimuli, and how their responses may encode mechanical cues.The ultimate goal is to provide a fundamentally new understanding of proprioception and motion sensing. The new multimodality approach generated in this project is expected to evolve as a national facility for neuro-mechanobiology, and future research may lead to the inspiration of novel bionic sensor design and brain-computer interface for future neuroengineering industry.Read moreRead less
Integrin Activation by Fluid Flow Disturbance: Mechanobiology Approaches. Understanding how cells can sense and respond to mechanical environment such as dynamic blood flow represents a fundamental question in the emerging field of mechanobiology. This project develops new biomechanical engineering approaches to determine the critical interrelationships among fluid flow disturbance, platelet clotting and the mechano-sensitive signal transduction mechanisms of integrin receptor – the most importa ....Integrin Activation by Fluid Flow Disturbance: Mechanobiology Approaches. Understanding how cells can sense and respond to mechanical environment such as dynamic blood flow represents a fundamental question in the emerging field of mechanobiology. This project develops new biomechanical engineering approaches to determine the critical interrelationships among fluid flow disturbance, platelet clotting and the mechano-sensitive signal transduction mechanisms of integrin receptor – the most important mechano-sensor implicated in cell adhesion, migration, growth and survival. Specifically, it integrates nationally unique cutting-edge techniques including single-molecule force probe, microparticle image velocimetry, microfluidics and molecular dynamics simulation, super resolution and 3D volumetric imaging modalities.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100487
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
Thermal hotspots detection in nanoscale two-dimensional electronics. The emergence of flexible nanoelectronics holds the promise to impact the way we live—from smart wearables to foldable smartphones. However, heat dissipation in the atomically-thin materials used for their conception has remained poorly understood due to their planar structures. This project aims at the detection and mapping of nanoscale thermal hotspots in flexible nanoelectronics devices using a two-dimensional-based optical ....Thermal hotspots detection in nanoscale two-dimensional electronics. The emergence of flexible nanoelectronics holds the promise to impact the way we live—from smart wearables to foldable smartphones. However, heat dissipation in the atomically-thin materials used for their conception has remained poorly understood due to their planar structures. This project aims at the detection and mapping of nanoscale thermal hotspots in flexible nanoelectronics devices using a two-dimensional-based optical thermometer. The expected outcome of this project is the development of a non-invasive thermometric technology that enables locating these critical nanoscale hotspots with nanoscale precision. This will lead to better design and manufacturing strategies for heat dissipation in these devices.Read moreRead less
Creating a non-invasive window into the mind. This project aims to create better tools to study the human mind. This project expects to generate new knowledge that can be used to non-invasively image neuronal activity. Expected outcomes include the development of unique new Magnetic Resonance Imaging (MRI) instruments to study neuronal activity in both highly controlled laboratory conditions and in humans, with the spatial and temporal resolution needed to study the neuronal circuitry that drive ....Creating a non-invasive window into the mind. This project aims to create better tools to study the human mind. This project expects to generate new knowledge that can be used to non-invasively image neuronal activity. Expected outcomes include the development of unique new Magnetic Resonance Imaging (MRI) instruments to study neuronal activity in both highly controlled laboratory conditions and in humans, with the spatial and temporal resolution needed to study the neuronal circuitry that drives low and high-level brain functions, i.e., creating a window into the mind. In the future, outcomes from this study could improve our understanding of mental disorders, advance computer brain interface technology, and inspire the next paradigm shift in artificial intelligence.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100144
Funder
Australian Research Council
Funding Amount
$415,154.00
Summary
Quantum-enabled super-resolution imaging. The aim is to design large scale, quantum-enabled imaging systems to boost the resolution of state-of-the-art instruments by three to five orders of magnitude. Using the toolbox of quantum information and quantum optics, the project expects to generate novel methods for 2D and 3D imaging, and precision measurements that can reach fundamental limits. Imaging is critical in much of today's research. The unparalleled resolution can benefit a broad range of ....Quantum-enabled super-resolution imaging. The aim is to design large scale, quantum-enabled imaging systems to boost the resolution of state-of-the-art instruments by three to five orders of magnitude. Using the toolbox of quantum information and quantum optics, the project expects to generate novel methods for 2D and 3D imaging, and precision measurements that can reach fundamental limits. Imaging is critical in much of today's research. The unparalleled resolution can benefit a broad range of scientific fields, the medical and the defence sector by resolving objects otherwise impossible. This project will strengthen Australia’s position as a world leader in quantum technologies by presenting solutions to overcome critical bottlenecks in imaging methods in the optical domain.Read moreRead less