ARC Centre of Excellence in Quantum Biotechnology. ARC Centre of Excellence in Quantum Biotechnology. The ARC Centre of Excellence in Quantum Biotechnology aims to develop paradigm-shifting quantum technologies to observe biological processes and transform our understanding of life. It seeks to create technologies that go far beyond what is possible today, from portable brain imagers to super-fast single protein sensors, and to use them to unravel key problems including how enzymes catalyse reac ....ARC Centre of Excellence in Quantum Biotechnology. ARC Centre of Excellence in Quantum Biotechnology. The ARC Centre of Excellence in Quantum Biotechnology aims to develop paradigm-shifting quantum technologies to observe biological processes and transform our understanding of life. It seeks to create technologies that go far beyond what is possible today, from portable brain imagers to super-fast single protein sensors, and to use them to unravel key problems including how enzymes catalyse reactions and how higher brain function emerges from networks of neurons. By building a diverse, multidisciplinary, and industry-engaged ecosystem, the Centre means to develop our future leaders at the interface of quantum science and biology and drive Australian innovation across manufacturing, energy, agriculture, health, and national security.Read moreRead less
New biosensing strategies based on bipolar electrochemiluminescence. Chemical analysis is a vital activity in our society, which is to a large extent confined to scientific laboratories and carried out with complex instrumentation. The breakthrough technology envisioned in this proposal will pave the way for simple, low-cost tests which can be used by non-scientists. The development of small, portable sensors for applications ranging from pollution monitoring to health testing, will enable ordi ....New biosensing strategies based on bipolar electrochemiluminescence. Chemical analysis is a vital activity in our society, which is to a large extent confined to scientific laboratories and carried out with complex instrumentation. The breakthrough technology envisioned in this proposal will pave the way for simple, low-cost tests which can be used by non-scientists. The development of small, portable sensors for applications ranging from pollution monitoring to health testing, will enable ordinary people to gain knowledge about the concentrations of molecular compounds in their environments and in themselves. This will stimulate economic and social benefits related to environmental testing and early disease diagnosis and generate new commercial opportunities for the Australian biotechnology industry.Read moreRead less
Replicating the cartilage micromechanical environment. Through a novel, image-guided mechanical evaluation of cell- and tissue-level remodelling, this project aims to unlock new insights into the complex mechanical microenvironment of cartilage and directly influence new strategies in tissue engineering. The research will reveal contributions of cells and extracellular matrix components to mechanical integrity over time. It will build a world-first strain map of the cartilage microenvironment an ....Replicating the cartilage micromechanical environment. Through a novel, image-guided mechanical evaluation of cell- and tissue-level remodelling, this project aims to unlock new insights into the complex mechanical microenvironment of cartilage and directly influence new strategies in tissue engineering. The research will reveal contributions of cells and extracellular matrix components to mechanical integrity over time. It will build a world-first strain map of the cartilage microenvironment and quantification of dynamic structural remodelling that occurs, providing key targets to improve tissue engineering strategies. The project will also drive innovation in micromechanical testing technology, deliver functional solutions in mechanobiology and advance materials for biological integration.Read moreRead less
Probing antimicrobial drug resistance by multimodal molecular analysis. This project aims to investigate drug resistance in microbial agents. With the emergence of "super bugs" there is a need to understand the biochemistry of antimicrobial resistance. Combining vibrational spectroscopic approaches and metabolomic techniques, the project will investigate cell populations, single cells and subcellular structures in search of biomarkers for drug resistance. The discovery of such biomarkers could l ....Probing antimicrobial drug resistance by multimodal molecular analysis. This project aims to investigate drug resistance in microbial agents. With the emergence of "super bugs" there is a need to understand the biochemistry of antimicrobial resistance. Combining vibrational spectroscopic approaches and metabolomic techniques, the project will investigate cell populations, single cells and subcellular structures in search of biomarkers for drug resistance. The discovery of such biomarkers could lead to improved disease management and eradication programs through identification and treatment of drug resistant pathogens in individuals that have the potential to re-infect the community.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220101085
Funder
Australian Research Council
Funding Amount
$434,000.00
Summary
3D metafibre optics for advanced imaging. The aim is to design and interface multi-functional metasurfaces with optical fibres by using 3D laser printing technology. The anticipated goal is to develop innovative metafibres interfaced with achromatic meta-lenses, polarisation-selective metasurfaces, and Fourier-space imaging metasurfaces for all-on-fibre achromatic, full-Stokes polarimetric, and Fourier endoscopic imaging, respectively. Expected outcomes include new knowledge in fibre meta-optics ....3D metafibre optics for advanced imaging. The aim is to design and interface multi-functional metasurfaces with optical fibres by using 3D laser printing technology. The anticipated goal is to develop innovative metafibres interfaced with achromatic meta-lenses, polarisation-selective metasurfaces, and Fourier-space imaging metasurfaces for all-on-fibre achromatic, full-Stokes polarimetric, and Fourier endoscopic imaging, respectively. Expected outcomes include new knowledge in fibre meta-optics and a novel metafibre manufacturing platform in a critical sector of the 21st-century economy. The novel ultracompact, flexible, and versatile metafibre technology is expected to have a profound impact on fibre-optic imaging in photonic, biological, and telecommunications applications.Read moreRead less
A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological respon ....A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological response from the nasal mucosa. The aim is to overcome a key fabrication challenge - to 3D print an anatomically accurate nasal construct with a porous wall on which to grow and mature functional nasal tissue that lines a nasal cavity wall. The benefit would be enabling faster development of more targeted drugs and vaccines.Read moreRead less
Robust, valid and interpretable deep learning for quantitative imaging. One of the biggest challenges in employing artificial intelligence is the “black-box” nature of the models used. This project aims to improve the effectiveness and trustworthiness of deep learning within quantitative magnetic resonance imaging. Deep learning has great promise in speeding-up complex image processing tasks, but currently suffers from variable data inputs, predictions are not guaranteed to be plausible and it i ....Robust, valid and interpretable deep learning for quantitative imaging. One of the biggest challenges in employing artificial intelligence is the “black-box” nature of the models used. This project aims to improve the effectiveness and trustworthiness of deep learning within quantitative magnetic resonance imaging. Deep learning has great promise in speeding-up complex image processing tasks, but currently suffers from variable data inputs, predictions are not guaranteed to be plausible and it is not clear to the end user how reliable the results are. The outcomes intend to deliver advanced knowledge and capability in artificial intelligence and machine learning that Australia urgently needs to capitalise on bringing deep learning into practical applications delivering economic, commercial and social impact.Read moreRead less
Dopant engineering of diamond for quantum sensing technologies. Doped diamonds are central to a growing range of quantum-sensing technologies for future industries, including medical and defence. These diamonds must be doped with both an electron donors and active 'quantum-defects' to operate. Within existing devices, the electronic donors also create parasitic magnetic noise, due to their magnetic-spin properties. In this project we aim to investigate the growth of diamond with new electronic d ....Dopant engineering of diamond for quantum sensing technologies. Doped diamonds are central to a growing range of quantum-sensing technologies for future industries, including medical and defence. These diamonds must be doped with both an electron donors and active 'quantum-defects' to operate. Within existing devices, the electronic donors also create parasitic magnetic noise, due to their magnetic-spin properties. In this project we aim to investigate the growth of diamond with new electronic donors, aiming for spin-free and thus noise-free dopant properties. This should provide significant benefits to defence capability, through enhanced magnetic anomaly detection in naval environments, and health outcomes, through neural sensing of brain signals at room temperature.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100433
Funder
Australian Research Council
Funding Amount
$390,627.00
Summary
Origins and implications of cosmic explosions . This project aims to solve the origin of Fast Radio Bursts (FRBs) by conducting a study of a large sample (>100) of localised bursts detected with a new coherent FRB detection system called CRACO deployed at the Australia Square Kilometre Array Pathfinder (ASKAP). Such a rich sample will enable novel studies of the structure of the Universe. The powerful and sensitive CRACO system will also search for transients that last for hundreds of millisecon ....Origins and implications of cosmic explosions . This project aims to solve the origin of Fast Radio Bursts (FRBs) by conducting a study of a large sample (>100) of localised bursts detected with a new coherent FRB detection system called CRACO deployed at the Australia Square Kilometre Array Pathfinder (ASKAP). Such a rich sample will enable novel studies of the structure of the Universe. The powerful and sensitive CRACO system will also search for transients that last for hundreds of milliseconds, exploring new types of astrophysical phenomena that give insight into the Universe's extremes. These discoveries will have a significant impact on science, establishing Australia as a key player in the international FRB community.
Read moreRead less
ARC Centre of Excellence for All Sky Astrophysics in 3 Dimensions. This Centre aims to answer fundamental questions in astrophysics including the origin of matter and the periodic table of elements, and the origin of ionisation in the Universe. It intends to use Australian three-dimensional technology to transform our understanding of the Universe. It will unify world-leading Australian optical and radio surveys with theoretical simulations and new e-Science techniques for Peta-scale data sets. ....ARC Centre of Excellence for All Sky Astrophysics in 3 Dimensions. This Centre aims to answer fundamental questions in astrophysics including the origin of matter and the periodic table of elements, and the origin of ionisation in the Universe. It intends to use Australian three-dimensional technology to transform our understanding of the Universe. It will unify world-leading Australian optical and radio surveys with theoretical simulations and new e-Science techniques for Peta-scale data sets. The Centre will also nurture young scientific leaders and make high-school students interested in STEM sciences through education and outreach programmes. It is expected the research will propel Australia to the forefront of astronomical research for the coming decade while capitalising on innovative instrumentation.Read moreRead less