Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100061
Funder
Australian Research Council
Funding Amount
$710,000.00
Summary
Extending frontiers of structural chemistry and biology through high resolution pulsed Electron Paramagnetic Resonance. Multifrequency high resolution pulsed Electron Paramagnetic Resonance (EPR) instrumentation will provide forefront technologies in identifying, characterising, quantifying and visualising free radicals and metal ions that are involved in fundamental chemical and biological processes in science and nature.
Discovery Early Career Researcher Award - Grant ID: DE220100748
Funder
Australian Research Council
Funding Amount
$420,000.00
Summary
Mechanofluorescent Surfaces for Understanding Complex Cell Traction Forces. This project aims to develop pressure-sensing surfaces that directly quantify surface forces, focused towards measuring complex cell traction forces. Understanding cell traction forces is a crucial challenge towards developing new materials for regenerative medicine. The surfaces, consisting of fluorescent polymer brushes, are expected to provide direct information on singular and clustered cell forces, which can reveal ....Mechanofluorescent Surfaces for Understanding Complex Cell Traction Forces. This project aims to develop pressure-sensing surfaces that directly quantify surface forces, focused towards measuring complex cell traction forces. Understanding cell traction forces is a crucial challenge towards developing new materials for regenerative medicine. The surfaces, consisting of fluorescent polymer brushes, are expected to provide direct information on singular and clustered cell forces, which can reveal new insight into how cells interact together. This may provide currently missing information on how cell-surface interaction forces modulate cell growth, differentiation and tissue formation. This insight is crucial to providing the underpinning science that can position Australia at the forefront of regenerative medicine.Read moreRead less
Dynamic electrochemistry with Bayesian inference. This project aims to develop and apply a highly advanced integrated research package in dynamic electrochemistry to molecules of biologically significance and ionic liquids of industrial importance. Experiments designed to understand electrochemical devices such as batteries and biosensors are often based on dynamic voltametric principles. This project will integrate alternating current voltametric instrumentation and software packages that model ....Dynamic electrochemistry with Bayesian inference. This project aims to develop and apply a highly advanced integrated research package in dynamic electrochemistry to molecules of biologically significance and ionic liquids of industrial importance. Experiments designed to understand electrochemical devices such as batteries and biosensors are often based on dynamic voltametric principles. This project will integrate alternating current voltametric instrumentation and software packages that model the relevant physical chemistry with data analysis tools derived from Bayesian inference. This project is expected to set a new standard for reporting and commercially exploiting statistically understood electrode kinetics. Basic data needed to develop platinum free fuel cells and other devices will emerge in this research programme.Read moreRead less
A new explanation for the hydrophobic effect. The hydrophobic effect is a fundamental natural phenomenon: why do oil and water spontaneously separate and not mix? The project team proposes a new and novel explanation for this effect, based on known properties of water. The project team's theory explains hydrophobic effects in physics, chemistry and biology.
Large amplitude Fourier transformed voltammetry with advanced data evaluation strategies: a roadmap for tackling stiff problems in electrochemistry. A range of stiff problems in dynamic electrochemistry will be addressed by implementation of a roadmap that integrates state-of-the-art instrumentation, theory and data analysis protocols. Substantial advantages will accrue in disciplines where fundamental and applied knowledge based on electron transfer processes is essential.
Discovery Early Career Researcher Award - Grant ID: DE220100511
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
Molecular-Scale Interaction of Nanomaterials with Biomembranes. This project aims to develop a holistic understanding of how nanoparticles, and nanomaterials in general, interact with cellular materials, via the cell membrane on a molecular level. To date, the precise mechanism by which nanomaterials, such as particles, colloids, and sheets, interact with cellular material is poorly understood.
This project expects to generate new, fundamental knowledge in the field, and establish a platform for ....Molecular-Scale Interaction of Nanomaterials with Biomembranes. This project aims to develop a holistic understanding of how nanoparticles, and nanomaterials in general, interact with cellular materials, via the cell membrane on a molecular level. To date, the precise mechanism by which nanomaterials, such as particles, colloids, and sheets, interact with cellular material is poorly understood.
This project expects to generate new, fundamental knowledge in the field, and establish a platform for high-resolution, in situ, molecular-scale imaging of nanoscale events at the biomembrane. This will develop a fundamental understanding of the dynamics of nanomaterial-cell interactions, and provide benefit in the development of next-generation nanomaterial-based therapeutics and diagnostic technologies.
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Engineering nanosheet-based novel structures. Microscopic structures will be engineered based on super thin materials, which promise to deliver significant advancements in the development of high sensitivity detectors, and efficient energy conversion and storage devices. This project will develop techniques that are not only green but also possess the flexibility to tailor-make novel structures.
Electronic-vibrational spectroscopy: A new probe for structure and function. This project aims to solve a major challenge in ultrafast spectroscopy: to identify and quantify competing reaction pathways in complex photochemical systems. Ultrafast Spectroscopy provides information on excited-state processes of photochemical reactions, however, unravelling heterogeneous systems with competing parallel processes remains difficult. Multidimensional electronic-vibrational spectroscopy, sensitive to el ....Electronic-vibrational spectroscopy: A new probe for structure and function. This project aims to solve a major challenge in ultrafast spectroscopy: to identify and quantify competing reaction pathways in complex photochemical systems. Ultrafast Spectroscopy provides information on excited-state processes of photochemical reactions, however, unravelling heterogeneous systems with competing parallel processes remains difficult. Multidimensional electronic-vibrational spectroscopy, sensitive to electronic dynamics and molecular structure, is expected to overcome this barrier. This new level of detail will profoundly enhance our understanding of energy and chemical conversion in complex systems and will reveal design targets for optimising next-generation light-energy harvesting, conducting, and emitting materials.Read moreRead less
Surfactants and complex fluids. This project aims to design surfactants for applications in agriculture and energy, and the science needed to understand and deploy them. New molecules have been designed based around the versatile betaine core, and their synthesis could allow a systematic understanding of the relationships between molecular architecture, effectiveness and self-assembly behaviour. This strategy will use molecules that can respond to light to understand why certain molecules tend t ....Surfactants and complex fluids. This project aims to design surfactants for applications in agriculture and energy, and the science needed to understand and deploy them. New molecules have been designed based around the versatile betaine core, and their synthesis could allow a systematic understanding of the relationships between molecular architecture, effectiveness and self-assembly behaviour. This strategy will use molecules that can respond to light to understand why certain molecules tend to form valuable viscoelastic fluids. When used to form complex fluids with unique properties, these surfactants could be used as lubricants, dispersants and energy fluids for use as drilling lubricants, texture modifiers in personal care products, and dispersants in agrochemicals.Read moreRead less
Integration of crystal engineering and electrochemistry: tuneable multifunctional organic-inorganic hybrid materials with redox capability. Multi-dimensional technologically important materials containing organic redox activity and organic, inorganic or biologically important functionality will be rationally synthesised. Scientists from different backgrounds will exploit opportunities for applied research outcomes derived from advances achieved in chemical, biological and materials sciences.