Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100061
Funder
Australian Research Council
Funding Amount
$710,000.00
Summary
Extending frontiers of structural chemistry and biology through high resolution pulsed Electron Paramagnetic Resonance. Multifrequency high resolution pulsed Electron Paramagnetic Resonance (EPR) instrumentation will provide forefront technologies in identifying, characterising, quantifying and visualising free radicals and metal ions that are involved in fundamental chemical and biological processes in science and nature.
Discovery Early Career Researcher Award - Grant ID: DE220100748
Funder
Australian Research Council
Funding Amount
$420,000.00
Summary
Mechanofluorescent Surfaces for Understanding Complex Cell Traction Forces. This project aims to develop pressure-sensing surfaces that directly quantify surface forces, focused towards measuring complex cell traction forces. Understanding cell traction forces is a crucial challenge towards developing new materials for regenerative medicine. The surfaces, consisting of fluorescent polymer brushes, are expected to provide direct information on singular and clustered cell forces, which can reveal ....Mechanofluorescent Surfaces for Understanding Complex Cell Traction Forces. This project aims to develop pressure-sensing surfaces that directly quantify surface forces, focused towards measuring complex cell traction forces. Understanding cell traction forces is a crucial challenge towards developing new materials for regenerative medicine. The surfaces, consisting of fluorescent polymer brushes, are expected to provide direct information on singular and clustered cell forces, which can reveal new insight into how cells interact together. This may provide currently missing information on how cell-surface interaction forces modulate cell growth, differentiation and tissue formation. This insight is crucial to providing the underpinning science that can position Australia at the forefront of regenerative medicine.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100193
Funder
Australian Research Council
Funding Amount
$700,000.00
Summary
Super High Resolution Correlative Microscopy: New Research Capability for Bioengineering, Clean Energy, Mineral Processing and Environmental Sciences. Super high resolution correlative microscopy: new research capability for bioengineering, clean energy, mineral processing and environmental sciences: This project will establish the first facility for super high resolution correlative microscopy in Australia. This facility will underpin breakthrough science by providing the capability to combine ....Super High Resolution Correlative Microscopy: New Research Capability for Bioengineering, Clean Energy, Mineral Processing and Environmental Sciences. Super high resolution correlative microscopy: new research capability for bioengineering, clean energy, mineral processing and environmental sciences: This project will establish the first facility for super high resolution correlative microscopy in Australia. This facility will underpin breakthrough science by providing the capability to combine and overlay conventional and super high resolution light microscopy information with electron microscopy information on identical sample locations. This new capability will foster advances in the fundamental understanding of multiscale hybrid organic and inorganic structures and spur the development of advanced (nano)materials and devices with broad applications in bioengineering and biofouling, advanced materials for life sciences, clean energy, water and the environment and mineral processing.Read moreRead less
Unravelling the structural complexity of ancient Australian arthropod venoms. Animal venoms contain a complex mix of molecules that have evolved over millions of years to target various biological processes. Their exquisite specificity and potent activity has made them an attractive source for development as therapeutic drugs with fewer side effects or as environmentally friendly insecticides. This project aims to for the first time explore the three-dimensional structure of all known classes of ....Unravelling the structural complexity of ancient Australian arthropod venoms. Animal venoms contain a complex mix of molecules that have evolved over millions of years to target various biological processes. Their exquisite specificity and potent activity has made them an attractive source for development as therapeutic drugs with fewer side effects or as environmentally friendly insecticides. This project aims to for the first time explore the three-dimensional structure of all known classes of toxins in the venom of two ancient Australian arthropods (spiders and centipedes). This will provide a comprehensive overview of these venoms and provide opportunities in engineering new classes of venom based drugs and insecticides. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100144
Funder
Australian Research Council
Funding Amount
$1,225,000.00
Summary
High Performance Single Crystal X-ray Diffraction Facility. This project aims to establish an advanced multidisciplinary facility for the structural characterisation of chemical and biological molecules. Through providing a broad suite of advanced capabilities, including measurement under a range of conditions and rapid crystal screening, the project expects to greatly accelerate research efforts across a wide spectrum of the molecular sciences. Expected outcomes include detailed understandings ....High Performance Single Crystal X-ray Diffraction Facility. This project aims to establish an advanced multidisciplinary facility for the structural characterisation of chemical and biological molecules. Through providing a broad suite of advanced capabilities, including measurement under a range of conditions and rapid crystal screening, the project expects to greatly accelerate research efforts across a wide spectrum of the molecular sciences. Expected outcomes include detailed understandings of the structures and functions of an array of scientifically and technologically important systems, spanning materials, proteins and pharmaceuticals. This should provide significant benefits, both in advancing the understanding of these systems and in spurring commercial development and application.Read moreRead less
Automated structural analysis of proteins by nuclear magnetic resonance (ASAP-NMR): a leap forward in structural studies of proteins using NMR spectroscopy. Proteins form the machinery that makes life possible, and this research will revolutionise study of their three-dimensional structure by making the process faster and cheaper. This approach will be applied to study proteins isolated from animal venoms in order to identify and develop novel pharmaceuticals and bio-insecticides.
Dynamic electrochemistry with Bayesian inference. This project aims to develop and apply a highly advanced integrated research package in dynamic electrochemistry to molecules of biologically significance and ionic liquids of industrial importance. Experiments designed to understand electrochemical devices such as batteries and biosensors are often based on dynamic voltametric principles. This project will integrate alternating current voltametric instrumentation and software packages that model ....Dynamic electrochemistry with Bayesian inference. This project aims to develop and apply a highly advanced integrated research package in dynamic electrochemistry to molecules of biologically significance and ionic liquids of industrial importance. Experiments designed to understand electrochemical devices such as batteries and biosensors are often based on dynamic voltametric principles. This project will integrate alternating current voltametric instrumentation and software packages that model the relevant physical chemistry with data analysis tools derived from Bayesian inference. This project is expected to set a new standard for reporting and commercially exploiting statistically understood electrode kinetics. Basic data needed to develop platinum free fuel cells and other devices will emerge in this research programme.Read moreRead less
Using light to move molecules-a novel approach to exploring intermolecular forces. It is in the last few nanometres above a surface that many real-world effects originate. Using a fine stylus and the momentum from a laser beam, the project will nano-mechanically perturb molecules to reveal forces on a sub-molecular scale. Gaining control at this scale is central to developing an understanding of many natural and industrial processes.
Surface forces between novel surfaces. Friction, adhesion, the self assembly of molecules essential to life and the flow properties of slurries is explained via an understanding of surface forces. These very short-range forces are often studied using ideal surfaces of very low roughness. As only a few surfaces are available with these ideal characteristics this has greatly limited the choice of materials that could previously be employed in surface force investigations. This project will use ato ....Surface forces between novel surfaces. Friction, adhesion, the self assembly of molecules essential to life and the flow properties of slurries is explained via an understanding of surface forces. These very short-range forces are often studied using ideal surfaces of very low roughness. As only a few surfaces are available with these ideal characteristics this has greatly limited the choice of materials that could previously be employed in surface force investigations. This project will use atomic layer deposition to produce thin films of novel materials that are extremely smooth and highly suitable for such investigations. Thereby, the understanding of surface forces, adhesion and adsorption phenomenon will be expanded to a wide range of new materials. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100163
Funder
Australian Research Council
Funding Amount
$860,365.00
Summary
Structure Determination Pipeline Capabilities for South Australia. This project aims to complete a high-throughput, automated pipeline for biomolecule crystallisation and provide enhanced X-ray structure determination capabilities for all sample types. This is critical because X-ray crystallography remains the primary technique for achieving molecular level insights to help solve cutting-edge problems in life, materials, chemical, earth and agricultural sciences. The diverse researcher community ....Structure Determination Pipeline Capabilities for South Australia. This project aims to complete a high-throughput, automated pipeline for biomolecule crystallisation and provide enhanced X-ray structure determination capabilities for all sample types. This is critical because X-ray crystallography remains the primary technique for achieving molecular level insights to help solve cutting-edge problems in life, materials, chemical, earth and agricultural sciences. The diverse researcher community in South Australia will benefit from a more rapid structure determination pipeline from molecular sample to structure. The infrastructure will drive research findings in energy and resources, food, soil and water security, advanced manufacturing and life sciences and lead to economic and technological impacts.Read moreRead less