Discovery Early Career Researcher Award - Grant ID: DE240100128
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
Engineering microenvironments to regulate osteocyte 3D networks in vitro. Most knowledge of bone is based on only a fraction of cells found in bone because the majority of cells in our bones (called osteocyte cell networks) cannot easily be grown or studied outside the body. This results in the inability to understand how the bone organ functions. Using bioinspired engineering, this project will use advanced biomaterials to biofabricate, for the first time, osteocyte cell networks in vitro. By u ....Engineering microenvironments to regulate osteocyte 3D networks in vitro. Most knowledge of bone is based on only a fraction of cells found in bone because the majority of cells in our bones (called osteocyte cell networks) cannot easily be grown or studied outside the body. This results in the inability to understand how the bone organ functions. Using bioinspired engineering, this project will use advanced biomaterials to biofabricate, for the first time, osteocyte cell networks in vitro. By unravelling how they are formed and controlled by manipulating their microenvironment, we will discover how different types of bones are formed. The benefits will be a valuable tool for the bone research community, allowing unresolved questions to be addressed in the future, such as how bone forms, repairs, and remodels.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100259
Funder
Australian Research Council
Funding Amount
$445,437.00
Summary
Next Generation Mass Spectrometry for Single-Cell Metabolomics. Characterising metabolites at the single cell level will provide valuable insights into the functionality of individual cells and reveal mechanisms that cannot be observed in bulk cell analysis. To address existing challenges in single-cell metabolite analysis, this project aims to develop an ultra-sensitive nanostructure-initiator mass spectrometry (NIMS) platform, which uses an innovative carbon material with a carefully designed ....Next Generation Mass Spectrometry for Single-Cell Metabolomics. Characterising metabolites at the single cell level will provide valuable insights into the functionality of individual cells and reveal mechanisms that cannot be observed in bulk cell analysis. To address existing challenges in single-cell metabolite analysis, this project aims to develop an ultra-sensitive nanostructure-initiator mass spectrometry (NIMS) platform, which uses an innovative carbon material with a carefully designed nanostructure to enhance detection efficiency. Expected outcomes include the development of a revolutionary carbon assisted NIMS platform for single-cell metabolomics analysis, and valuable intellectual property of commercial interest to provide economic benefit to Australia through technology advancement.Read moreRead less
Innovative Stable Free Radical-Substituted Conjugated Electronic Polymers. The project aims to develop an innovative class of stable free radicals side-chain substituted conjugated donor-acceptor electronic polymers with unique polaronic and radical charge transport capabilities. The targeted optoelectronic material class is unique and has not been explored in depth before. The combination of unpaired electrons and delocalized backbone -electrons delivers exciting modes of charge transfer that ....Innovative Stable Free Radical-Substituted Conjugated Electronic Polymers. The project aims to develop an innovative class of stable free radicals side-chain substituted conjugated donor-acceptor electronic polymers with unique polaronic and radical charge transport capabilities. The targeted optoelectronic material class is unique and has not been explored in depth before. The combination of unpaired electrons and delocalized backbone -electrons delivers exciting modes of charge transfer that provide these novel materials with clear potential as electroactive materials with applications in various nanoelectronics devices. Developing a fundamental understanding of charge transport properties and potential device applications will open up a new field of research in advanced optoelectronic technology. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100236
Funder
Australian Research Council
Funding Amount
$463,583.00
Summary
Designing and fabricating artificial blood cells for global shortages. This project aims to create the first biophysically accurate artificial blood cells through fabrication of novel synthetic particles that mimic the complex layers of red blood cells. Using innovative methods from engineering and biology, this project expects to advance biofabrication techniques for biosynthetic microparticles. Expected outcomes from this project include the development of a portable, cost-effective platform t ....Designing and fabricating artificial blood cells for global shortages. This project aims to create the first biophysically accurate artificial blood cells through fabrication of novel synthetic particles that mimic the complex layers of red blood cells. Using innovative methods from engineering and biology, this project expects to advance biofabrication techniques for biosynthetic microparticles. Expected outcomes from this project include the development of a portable, cost-effective platform technology to immediately advance foundational understanding of cell membrane dynamics, interactions, and integrity. We anticipate that the new bioengineered blood product will provide significant future benefits for blood storage and transfusion, including potentially alleviating global blood shortages.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100408
Funder
Australian Research Council
Funding Amount
$446,411.00
Summary
Advancing bioelectronics with silicon carbide on microfluidics. Flexible bioelectronics is an emerging technology for real-time monitoring of vital signals on skin and in the body. Microfluidics is a technology for fluid handling in microscale. This project aims to develop the first platform technology with both flexible bioelectronics and microfluidics for enhanced sensing, thermal management and actuation. The project is expected to establish new fundamental knowledge in sensitivity boosting m ....Advancing bioelectronics with silicon carbide on microfluidics. Flexible bioelectronics is an emerging technology for real-time monitoring of vital signals on skin and in the body. Microfluidics is a technology for fluid handling in microscale. This project aims to develop the first platform technology with both flexible bioelectronics and microfluidics for enhanced sensing, thermal management and actuation. The project is expected to establish new fundamental knowledge in sensitivity boosting mechanisms with nano-thin semiconducting films, practical prototypes for long-lasting bioelectronics with integrated microfluidics and their large-scale manufacturing processes. Outcomes include step changes in designing innovative wearable and implantable devices and their massive commercialisation opportunities.Read moreRead less
Mathematical and Numerical Models of Piezoelectric Wave Energy Converters. The project will investigate piezoelectric wave energy converters. We will derive the equations of motion in a form suitable for use in marine engineering paradigms using variational methods and then solve these analytically and with smoothed particle hydrodynamics. Using these innovative techniques, this project will generate new knowledge capable of elucidating the multifaceted physical phenomena that occur when comple .... Mathematical and Numerical Models of Piezoelectric Wave Energy Converters. The project will investigate piezoelectric wave energy converters. We will derive the equations of motion in a form suitable for use in marine engineering paradigms using variational methods and then solve these analytically and with smoothed particle hydrodynamics. Using these innovative techniques, this project will generate new knowledge capable of elucidating the multifaceted physical phenomena that occur when complex fluid motion and deformable structures interact. The project outcomes include the development of mathematical and computation methods to handle intricate behaviours of piezoelectric elastic-fluids systems. These groundbreaking methods will allow these wave energy systems to be analysed and their effectiveness assessed.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL230100100
Funder
Australian Research Council
Funding Amount
$3,300,000.00
Summary
Forces in Nature: Tissue mechanics and cell sociology. Epithelial cells cover surfaces in the body, forming a shield to protect us from the environment. Despite their importance, we understand poorly how the cells communicate. This project aims to test the novel concept that epithelial cells communicate via transmission and detection of mechanical forces, using an innovative combination of cellular and biophysical experiments and physical theory. The expected outcomes are new knowledge, interdis ....Forces in Nature: Tissue mechanics and cell sociology. Epithelial cells cover surfaces in the body, forming a shield to protect us from the environment. Despite their importance, we understand poorly how the cells communicate. This project aims to test the novel concept that epithelial cells communicate via transmission and detection of mechanical forces, using an innovative combination of cellular and biophysical experiments and physical theory. The expected outcomes are new knowledge, interdisciplinary training for young scientists, new national research capacity and growing international collaborations. Benefits include enhancing Australia’s scientific linkages and research capacity and providing fundamental knowledge that could lead to future advances in bioengineering and drug discovery. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240101231
Funder
Australian Research Council
Funding Amount
$411,837.00
Summary
Quinoid Polymers for Organic Electrochemical Transistors and Bioelectronics. This project aims to develop organic semiconductors (OSCs) with excellent mechanical flexibility and biocompatibility to exploit their potentials in bioelectronics. It connects the electronic world with ionic world of biology to push the biomedical application of OSCs a big step forward. Interdisciplinary knowledge, intellectual properties (IPs), top-notch publications, invited talks, and international collaborations ar ....Quinoid Polymers for Organic Electrochemical Transistors and Bioelectronics. This project aims to develop organic semiconductors (OSCs) with excellent mechanical flexibility and biocompatibility to exploit their potentials in bioelectronics. It connects the electronic world with ionic world of biology to push the biomedical application of OSCs a big step forward. Interdisciplinary knowledge, intellectual properties (IPs), top-notch publications, invited talks, and international collaborations are expected. Additionally, it will earn Australia a commercial lead in the biomedical sector to attract more talents to serve Australia. This project also matches well with several government’s strategic research priorities, attracting industries to realise IPs transfer to bring “great value for money” to feed back Australia.Read moreRead less
Identifying how cortical bone microstructure deteriorates with age. This project aims to define the disruptions responsible for the gradual weakening of the skeleton in ageing by integrating a range of high-resolution imaging, biomechanical, and computational methods. The expected significance of this project includes a full definition and comparison of the cellular and subcellular organisation of bone from young and elderly individuals. Expected outcomes of this international project include th ....Identifying how cortical bone microstructure deteriorates with age. This project aims to define the disruptions responsible for the gradual weakening of the skeleton in ageing by integrating a range of high-resolution imaging, biomechanical, and computational methods. The expected significance of this project includes a full definition and comparison of the cellular and subcellular organisation of bone from young and elderly individuals. Expected outcomes of this international project include the establishment of a new multidisciplinary research team, and the development of a new data-driven theoretical framework for understanding the nature and the causes of age-related bone fragility. Potential long-term benefits include new ways to treat age-related osteoporosis.Read moreRead less
ARC Centre of Excellence for Gravitational Wave Discovery. ARC Centre of Excellence for Gravitational Wave Discovery. The mission of our Centre is to use gravitational waves to investigate the fundamental nature of relativistic gravity, ultra-dense matter, and cosmology. This will generate critical discoveries that cement Australia's leadership role in the gravitational wave mega-science instruments of the 2030s and 2040s. By bringing together a world-class team with broad and complementary expe ....ARC Centre of Excellence for Gravitational Wave Discovery. ARC Centre of Excellence for Gravitational Wave Discovery. The mission of our Centre is to use gravitational waves to investigate the fundamental nature of relativistic gravity, ultra-dense matter, and cosmology. This will generate critical discoveries that cement Australia's leadership role in the gravitational wave mega-science instruments of the 2030s and 2040s. By bringing together a world-class team with broad and complementary expertise we will develop core technologies for future detectors, discover new sources of gravitational waves, probe fundamental physics, and lay the foundations for an Australian gravitational wave observatory. Our discoveries will inspire Australia's youth to pursue high tech careers and position our staff and students to become leaders in both industry and academia.Read moreRead less