Effects Of Fast Versus Slow Weight Loss On Fat, Muscle And Bone In Postmenopausal Women
Funder
National Health and Medical Research Council
Funding Amount
$316,450.00
Summary
Very low energy diets (VLED) are increasingly used to treat obesity. Of concern is the fact that VLED induce adaptive responses that can inhibit loss of, and promote regain of, abdominal fat while decreasing lean body mass, muscle strength and bone density. This project will therefore determine whether VLEDs could have negative effects on body composition that increase the risk of metabolic disease, sarcopenia or osteoporosis, and if so, what mechanisms are involved.
Myeloma Plasma Cell Dormancy - 'Eradicating The Sleeping Giant'
Funder
National Health and Medical Research Council
Funding Amount
$834,428.00
Summary
Multiple myeloma is a fatal cancer that develops in the skeleton. Current therapies are initially effective, but patients develop resistance and the disease returns. This makes the search for drugs to overcome resistance a priority. Myeloma cells can hide in bone in a dormant state where they are insensitive to chemotherapy. We have identified new drug targets in dormant cells. We are investigating whether these new targets can be used eradicate myeloma cells and cure the disease.
The BEST At Home Pragmatic Fall Prevention Program: Effectiveness, Cost Effectiveness And Implementation
Funder
National Health and Medical Research Council
Funding Amount
$1,386,133.00
Summary
Falls are a major public health issue with enormous personal, social and economic consequences. Certain types of exercise can prevent falls, however new strategies are needed to implement these programs more effectively to maximise uptake and adherence by older people. Researchers in fall prevention and health promotion are partnering with the Illawarra Shoalhaven Local Health District to evaluate the fall prevention effect of the Otago Exercise Programme when implemented in a group-based worksh ....Falls are a major public health issue with enormous personal, social and economic consequences. Certain types of exercise can prevent falls, however new strategies are needed to implement these programs more effectively to maximise uptake and adherence by older people. Researchers in fall prevention and health promotion are partnering with the Illawarra Shoalhaven Local Health District to evaluate the fall prevention effect of the Otago Exercise Programme when implemented in a group-based workshop format for older community-dwelling people.Read moreRead less
Hydrological changes in Australia and the South Pacific. This project plans to use stalagmites from the South–West Pacific to generate continuous rainfall records for the last 2000 years. Stalagmites contain uncorrupted data that are not available in other archives, and provide unparalleled accurate chronologies. The spatial and temporal variations of the data may highlight the interplay of climate drivers, such as El Niño Southern Oscillation, and how they change the distribution of rainfall in ....Hydrological changes in Australia and the South Pacific. This project plans to use stalagmites from the South–West Pacific to generate continuous rainfall records for the last 2000 years. Stalagmites contain uncorrupted data that are not available in other archives, and provide unparalleled accurate chronologies. The spatial and temporal variations of the data may highlight the interplay of climate drivers, such as El Niño Southern Oscillation, and how they change the distribution of rainfall in the Pacific. This knowledge would increase our scientific understanding and enable better predictions of the recurrence of droughts and wet events in Australia.Read moreRead less
Reconstructing changes in atmospheric circulation over the mid-latitudes of the Southern Hemisphere during the past 3000 years. The climate of the mid-latitudes of the southern hemisphere is of global significance and yet past changes have proved difficult to reconstruct due to the dearth of records. Working across the Southern Ocean region using tree rings, lake sediments and ice cores, the project will produce the first comprehensive reconstruction spanning the last 3000 years.
Australian Laureate Fellowships - Grant ID: FL100100195
Funder
Australian Research Council
Funding Amount
$2,981,452.00
Summary
Tipping points in Records of Extreme Events in Australasia: Using the Past to Understand and Plan for Abrupt Future Climate Change. This project will generate the fundamental science outputs required to extend historical records of change and understand the complex linkages between Australian and global atmospheric, terrestrial and marine processes in the climate system, thereby assisting in: (i) identifying the mechanisms of past and future climate variability; (ii) developing and validating me ....Tipping points in Records of Extreme Events in Australasia: Using the Past to Understand and Plan for Abrupt Future Climate Change. This project will generate the fundamental science outputs required to extend historical records of change and understand the complex linkages between Australian and global atmospheric, terrestrial and marine processes in the climate system, thereby assisting in: (i) identifying the mechanisms of past and future climate variability; (ii) developing and validating methodologies for improved climate reconstruction and robust chronological frameworks; (iii) predicting the response of Australian ecosystems to future climate change; and (iv) communicating the research outputs to the general public and state, national and international decision makers, helping scientific understanding and aiding resource management.Read moreRead less
The Great Barrier Reef in 2100. Our research aims to answer fundamental geomorphic questions about the future of coral reefs, focusing on the Great Barrier Reef (GBR). We will develop cutting-edge, fully open-source numerical models to quantify the eco-morphodynamic evolution of the GBR under IPCC climate-change scenarios. Our geomorphic numerical models will consider biotic/abiotic feedbacks including synergistic effects of multiple stressors such as waves, temperature, acidification and sedime ....The Great Barrier Reef in 2100. Our research aims to answer fundamental geomorphic questions about the future of coral reefs, focusing on the Great Barrier Reef (GBR). We will develop cutting-edge, fully open-source numerical models to quantify the eco-morphodynamic evolution of the GBR under IPCC climate-change scenarios. Our geomorphic numerical models will consider biotic/abiotic feedbacks including synergistic effects of multiple stressors such as waves, temperature, acidification and sediment transport, at individual reef scales. We will model the future of the GBR’s ecosystem-services, allowing for a quantum leap in the geomorphic knowledge and understanding of coral reef ecosystems. Expected outcomes include a gamechanger tool for future management of the GBR.Read moreRead less
Multi-variable based vegetation monitoring and prediction during droughts. This project aims to reduce the uncertainties in characterizing and predicting drought impacts on Australian ecosystems. This project is expected to better understand how vegetation responded to hydro-meteorological conditions from the onset to termination stages during Australian droughts in the past 40 years, by investigating the newly developed first global long-term vegetation water content record from satellites. Exp ....Multi-variable based vegetation monitoring and prediction during droughts. This project aims to reduce the uncertainties in characterizing and predicting drought impacts on Australian ecosystems. This project is expected to better understand how vegetation responded to hydro-meteorological conditions from the onset to termination stages during Australian droughts in the past 40 years, by investigating the newly developed first global long-term vegetation water content record from satellites. Expected outcomes of this project will be the enhanced capacity to better identify early warning signals and more accurately predict vegetation responses to future droughts. This should provide significant benefits in developing drought mitigation strategies for national agricultural production and water resource allocation.Read moreRead less
Dynamics of carbonate sands and morphodynamics of coral reef environments. Coral reefs are mainly composed of mobile sedimentary deposits that influence the living regions of the coral reefs. Using sites on Australia's Great Barrier Reef, the project will learn how, why and how fast sand advances, and will predict how these processes will change in response to predicted rises in sea levels.