Mosquito-borne alphaviruses such as Ross River and chikungunya viruses cause widespread epidemics and exert extreme pressure on the public health systems of affected regions. Alphaviruses spreads to joints and triggers a severe disease in those affected. There are no effective treatments or vaccines. The project will investigate virus-host interaction at the bite site. The outcome will be new knowledge to treat infection at the mosquito bite site to prevent joint disease.
Novel Insights Into The Pathobiology Of Alphavirus Infections
Funder
National Health and Medical Research Council
Funding Amount
$827,660.00
Summary
Infections with mosquito-borne viruses are increasing at an alarming rate worldwide. Ross River virus is endemic in parts of Australia, PNG and Pacific islands, while chikungunya virus is distributed globally and causes recurrent pandemics that involve millions of people. These viruses cause severe musculoskeletal disease for several months after infection. This project aims to establish how these viruses interact with the human host to cause disease and may provide a basis for new treatments.
New Insights Into Viral Inflammatory Disease Mechanisms And Approaches To Therapy
Funder
National Health and Medical Research Council
Funding Amount
$631,010.00
Summary
This fellowship aims to establish how viruses cause disease, including how they evade the immune response to persist and cause disease for prolonged periods. My vision is that knowing how the virus and the immune system interact to determine disease severity will assist in devising new treatments and prevention programs to lessen the impact of viral diseases in Australia and worldwide.
The modern Athenians: Francis Jeffrey's Edinburgh Review (1802-1829) in the 'knowledge economy' of the early nineteenth century. This study of the multi-disciplinary nature and influence of the Edinburgh Review under Francis Jeffrey and its contribution to the organisation and dissemination of knowledge in the early nineteenth-century utilises developments in web design and technology to create a comprehensive website dedicated to Edinburgh Review.
New carbon phases synthesized under extreme conditions. This project aims to address one of the major fundamental puzzles in carbon science; how to experimentally synthesize new phases of carbon predicted by theory. This could be approached via a combination of high pressure and high-energy ion irradiation to transform novel nano-carbon precursors. The expected outcomes include new phases of carbon with unexplored properties, an understanding of the pathways for synthesis of carbon materials, an ....New carbon phases synthesized under extreme conditions. This project aims to address one of the major fundamental puzzles in carbon science; how to experimentally synthesize new phases of carbon predicted by theory. This could be approached via a combination of high pressure and high-energy ion irradiation to transform novel nano-carbon precursors. The expected outcomes include new phases of carbon with unexplored properties, an understanding of the pathways for synthesis of carbon materials, and new computational tools to understand nano-carbon materials under extreme conditions. This should provide benefits for industries seeking advanced materials for modern manufacturing.Read moreRead less
Spectacle and Multimedia in Late-Eighteenth-Century Europe: a programme of written and multi-media histories. I aim to demonstrate that Philippe de Loutherbourg, an eighteenth-century European artist and set-designer, pioneered revolutionary developments in the technology and culture of multi-media through the agency of 'spectacles.' These multi-sensory displays for entertainment and knowledge foreshadow the advent of modern cinema and multimedia, and suggest new ways of praticing history throug ....Spectacle and Multimedia in Late-Eighteenth-Century Europe: a programme of written and multi-media histories. I aim to demonstrate that Philippe de Loutherbourg, an eighteenth-century European artist and set-designer, pioneered revolutionary developments in the technology and culture of multi-media through the agency of 'spectacles.' These multi-sensory displays for entertainment and knowledge foreshadow the advent of modern cinema and multimedia, and suggest new ways of praticing history through multimedia re-creations.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100023
Funder
Australian Research Council
Funding Amount
$650,000.00
Summary
Australian high field electron paramagnetic resonance facility. This project aims to establish Australia’s first a high-field (3 T, 94 GHz) high-field pulse electron paramagnetic resonance (EPR) facility. EPR is a powerful technique to study chemical, biological and materials systems. It represents a sensitive, non-invasive, site-selective spectroscopy for the analysis of both molecular and macroscopic properties. This facility will allow the further development and implementation of new multidi ....Australian high field electron paramagnetic resonance facility. This project aims to establish Australia’s first a high-field (3 T, 94 GHz) high-field pulse electron paramagnetic resonance (EPR) facility. EPR is a powerful technique to study chemical, biological and materials systems. It represents a sensitive, non-invasive, site-selective spectroscopy for the analysis of both molecular and macroscopic properties. This facility will allow the further development and implementation of new multidimensional pulse EPR techniques, enabling domestic and international collaborations with diverse applications in structural biology, solvation science and catalysis.Read moreRead less
The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which ....The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which sex genes are targets? Epigenetic enzymes are astonishingly conserved, providing exciting opportunities to draw from human systems to unravel novel signatures of temperature-induced sex switching in reptiles. This project will advance knowledge of developmental programming generally.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL130100141
Funder
Australian Research Council
Funding Amount
$1,996,807.00
Summary
The origins of inequality, hierarchy, and social complexity. Despite obvious failures, humans cooperate far more than other mammals. This project explains how we came to be so unlike other animals; how our cooperative practices transformed us; and how those practices changed, as human societies became increasingly complex after the invention of farming.
Finding equivalence between natural and artificial intelligences. This project aims to investigate the ways in which artificial intelligence is equivalent to human intelligence. Computers outperform humans in many domains, yet it is clear that computers often don’t perform tasks the way humans do. Developing innovative methods for evaluating claims of equivalence by drawing on simpler, well-understood model systems like the honeybee brain, the project expects to fill this existing knowledge gap. ....Finding equivalence between natural and artificial intelligences. This project aims to investigate the ways in which artificial intelligence is equivalent to human intelligence. Computers outperform humans in many domains, yet it is clear that computers often don’t perform tasks the way humans do. Developing innovative methods for evaluating claims of equivalence by drawing on simpler, well-understood model systems like the honeybee brain, the project expects to fill this existing knowledge gap. Expected outcomes include a framework that provides powerful, nuanced criteria for comparison of natural and artificial intelligences. Benefits are expected to include enhanced guidance for the development of AI systems both in everyday contexts and as exploratory tools in comparative and cognitive neuroscience.Read moreRead less