Tracking The Impact Of Drug Regulatory Actions: Consumer Health Outcomes, Risk-benefit Issues And Policy Framework.
Funder
National Health and Medical Research Council
Funding Amount
$439,324.00
Summary
This study will explore what happens in the community when a medicine is withdrawn from the market or discredited due to safety concerns. It will examine the impacts of two recent cases of medicine withdrawal or serious long-term safety concern, on a large cohort of women with high utilisation rates who were monitored during the time the medicines were discredited. The study will be an important guide to future regulatory, media and provider responses when medicines are discredited.
A comparative sociocultural and bioethical study of uterus transplants . This socio-cultural study aims to undertake a comparative study of the new Australian Uterine Transplant (UTx) trial with established and emerging UTx programs in the US and India. Expected outcomes of this project include: enhanced understandings of the experiences and meanings of uterine transplant for women donors, recipients and staff involved in UTx trials; an exploration of the ethical issues raised by this technolog ....A comparative sociocultural and bioethical study of uterus transplants . This socio-cultural study aims to undertake a comparative study of the new Australian Uterine Transplant (UTx) trial with established and emerging UTx programs in the US and India. Expected outcomes of this project include: enhanced understandings of the experiences and meanings of uterine transplant for women donors, recipients and staff involved in UTx trials; an exploration of the ethical issues raised by this technology; and a comparison of social responses to uterine transplants across different societies.This study is anticipated to provide theoretical insights on the social and ethical impacts of this technology for improved public policy responses. Read moreRead less
Understanding the Australian public's expectations of personalised genomics. This multi-disciplinary project aims to be the first to explore the Australian public's awareness of new developments in genetic science that allow healthy individuals to access their own genetic makeup. Called 'personal genomics', this broad group of genetic tests can be used for a variety of purposes that include ancestry, paternity, sporting ability and health. These tests are developing at a rapid rate yet little is ....Understanding the Australian public's expectations of personalised genomics. This multi-disciplinary project aims to be the first to explore the Australian public's awareness of new developments in genetic science that allow healthy individuals to access their own genetic makeup. Called 'personal genomics', this broad group of genetic tests can be used for a variety of purposes that include ancestry, paternity, sporting ability and health. These tests are developing at a rapid rate yet little is known about why, how and where they are used by the public. This project will employ a mixed methods approach to examine how the public might engage with this new technology. The research aims to help define educational strategies and supports and thereby to inform national policy for personal genomics.Read moreRead less
Fate of engineered nanoparticles: Challenges in informing human and ecological health risk assessments. Engineered nanoparticles (ENPs) have generated significant public and scientific excitement due to their unique properties. This has led to their application in a wide variety of industries (for example, in composite materials and drug delivery). However, there is concern that some ENPs can have detrimental environmental impacts. This project aims to quantify, for the first time, the fate of E ....Fate of engineered nanoparticles: Challenges in informing human and ecological health risk assessments. Engineered nanoparticles (ENPs) have generated significant public and scientific excitement due to their unique properties. This has led to their application in a wide variety of industries (for example, in composite materials and drug delivery). However, there is concern that some ENPs can have detrimental environmental impacts. This project aims to quantify, for the first time, the fate of ENPs that have leached out of commercial products in groundwater systems. This information is expected to assist regulators in developing appropriate legislation to balance the tremendous benefits and potential risks of nanotechnology.Read moreRead less
Monitoring organic matter in drinking water systems using fluorescence spectroscopy: improved early warning, process optimisation and water quality. Climate change is contributing to elevated organic matter (OM) concentrations in drinking water supplies. If insufficiently treated, OM can lead to unacceptable concentrations of disinfection by-products, considered to be potential carcinogens, as well as taste and odour problems and bacterial re-growth in the distribution system. Currently availabl ....Monitoring organic matter in drinking water systems using fluorescence spectroscopy: improved early warning, process optimisation and water quality. Climate change is contributing to elevated organic matter (OM) concentrations in drinking water supplies. If insufficiently treated, OM can lead to unacceptable concentrations of disinfection by-products, considered to be potential carcinogens, as well as taste and odour problems and bacterial re-growth in the distribution system. Currently available on-line monitoring techniques give limited information regarding the nature of OM; however, fluorescence spectroscopy has shown promise in this regard. Hence, this project aims to provide an on-line monitoring protocol utilising fluorescence to aid utilities in their provision of safe drinking water, thus addressing the National Research Priority goal water – a critical resource.Read moreRead less
Ammonia recovery from wastewaters using flow electrode-membrane systems. This project aims to develop an innovative approach to the recovery of ammonia from dilute wastewaters using coupled-flow electrode-membrane technologies that also enable energy recovery. The outcome of the project is expected to minimise damage to, and develop solutions for, restoration and remediation of, soil, fresh and potable water, urban catchments and marine systems, and significantly improve the environmental impact ....Ammonia recovery from wastewaters using flow electrode-membrane systems. This project aims to develop an innovative approach to the recovery of ammonia from dilute wastewaters using coupled-flow electrode-membrane technologies that also enable energy recovery. The outcome of the project is expected to minimise damage to, and develop solutions for, restoration and remediation of, soil, fresh and potable water, urban catchments and marine systems, and significantly improve the environmental impacts of ammonia.Read moreRead less
Preventing Anxiety, Depression And Substance Use In Adolescents.
Funder
National Health and Medical Research Council
Funding Amount
$1,709,988.00
Summary
Anxiety, depressive and substance use disorders account for three quarters of the disability attributed to mental disorders. Yet we have few models of well-implemented prevention programs for these common disorders. The current proposal addresses this gap by evaluating an innovative internet-based approach to preventing mental health and substance use problems in Australian adolescents.
Smart management of disinfectant in chloraminated water-supply systems. Smart management of disinfectant in chloraminated water-supply systems. This project aims to develop an adaptive, real-time control system for managing disinfectant residuals in chloraminated water supply systems. While chloramine delivers microbiologically safe drinking water in warmer climates and in long distribution systems, it is largely unpredictable, costs water utilities millions of dollars annually, and has uncertai ....Smart management of disinfectant in chloraminated water-supply systems. Smart management of disinfectant in chloraminated water-supply systems. This project aims to develop an adaptive, real-time control system for managing disinfectant residuals in chloraminated water supply systems. While chloramine delivers microbiologically safe drinking water in warmer climates and in long distribution systems, it is largely unpredictable, costs water utilities millions of dollars annually, and has uncertain benefits. This project’s control system will be guided by quantitative models formulated from multi-pronged, fundamental experiments. The project will quantify microbial chloramine decay and determine mechanisms to increase predictability. The project will develop and demonstrate a real-time control technology which delivered microbiologically safe, cost-efficient drinking water to people in warmer climates, despite warming climate and increasing population.Read moreRead less
Special Research Initiatives - Grant ID: SR180200015
Funder
Australian Research Council
Funding Amount
$589,007.00
Summary
Combination of electrochemistry with sono to destroy and detoxify PFAS. Previously the major means of dealing with per- and poly-fluoroalkyl substances (PFAS) is by adsorption, to collect and remove PFAS from contaminated sites. However, PFAS still exist, non-degraded and waiting for destruction. Targeting slurry waste from current remediation / adsorption plants, this project aims to efficiently degrade PFAS by combining electrochemical oxidation with sono-chemistry to enhance degradation capac ....Combination of electrochemistry with sono to destroy and detoxify PFAS. Previously the major means of dealing with per- and poly-fluoroalkyl substances (PFAS) is by adsorption, to collect and remove PFAS from contaminated sites. However, PFAS still exist, non-degraded and waiting for destruction. Targeting slurry waste from current remediation / adsorption plants, this project aims to efficiently degrade PFAS by combining electrochemical oxidation with sono-chemistry to enhance degradation capacity, to accelerate PFAS desorption / transportation from slurry waste, to avoid electrode fouling and to detoxify PFAS. The expected outcome of this project is to clean up contaminated sites, including PFAS / precursors and other persistent organic pollutants, leading to significant environmental benefits.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100807
Funder
Australian Research Council
Funding Amount
$321,536.00
Summary
Anion transporters as novel therapeutic agents. This project plans to use simulations and modelling for the rational design of anion transporters as therapeutic agents. Malfunctioning of certain anion transport mechanisms can lead to serious diseases, most notably cystic fibrosis. Anion transporters are molecules that mediate the lipid bilayer transport of negatively charged ions, and are therefore promising drug candidates for the treatment of these diseases. Many of these compounds also displa ....Anion transporters as novel therapeutic agents. This project plans to use simulations and modelling for the rational design of anion transporters as therapeutic agents. Malfunctioning of certain anion transport mechanisms can lead to serious diseases, most notably cystic fibrosis. Anion transporters are molecules that mediate the lipid bilayer transport of negatively charged ions, and are therefore promising drug candidates for the treatment of these diseases. Many of these compounds also display anti-tumour properties. The intended outcome of this project is the development of new tools to accelerate the discovery of novel anion transporters, understand their structure activity relationship, and design more effective therapeutic agents.Read moreRead less